Literature DB >> 32022298

Insulin resistance and impaired lipid metabolism as a potential link between diabetes and Alzheimer's disease.

Joshua A Kulas1, Thaddeus K Weigel2, Heather A Ferris1,2.   

Abstract

Diabetes disrupts organs throughout the body including the brain. Evidence suggests diabetes is a risk factor for Alzheimer's disease (AD) and neurodegeneration. In this review, we focus on understanding how diabetes contributes to the progression of neurodegeneration by influencing several aspects of the disease process. We emphasize the potential roles of brain insulin resistance, as well as cholesterol and lipid disruption, as factors which worsen AD.
© 2020 Wiley Periodicals, Inc.

Entities:  

Keywords:  Alzheimer's; cholesterol; diabetes; insulin resistance; oxidized lipids

Mesh：

Year:  2020        PMID： 32022298      PMCID： PMC7976446          DOI： 10.1002/ddr.21643

Source DB:  PubMed          Journal:  Drug Dev Res        ISSN： 0272-4391            Impact factor:   4.360


  158 in total

Review 1.  Inflammation and metabolic disorders.

Authors:  Gökhan S Hotamisligil
Journal:  Nature       Date:  2006-12-14       Impact factor: 49.962

2.  Insulin-like growth factor I mRNA levels are developmentally regulated in specific regions of the rat brain.

Authors:  M A Bach; Z Shen-Orr; W L Lowe; C T Roberts; D LeRoith
Journal:  Brain Res Mol Brain Res       Date:  1991-04

3.  Diabetes induces mitochondrial dysfunction and alters cholesterol homeostasis and neurosteroidogenesis in the rat cerebral cortex.

Authors:  Simone Romano; Nico Mitro; Silvia Giatti; Silvia Diviccaro; Marzia Pesaresi; Roberto Spezzano; Matteo Audano; Luis Miguel Garcia-Segura; Donatella Caruso; Roberto Cosimo Melcangi
Journal:  J Steroid Biochem Mol Biol       Date:  2017-11-26       Impact factor: 4.292

4.  Brain glutathione levels--a novel biomarker for mild cognitive impairment and Alzheimer's disease.

Authors:  Pravat K Mandal; Sumiti Saharan; Manjari Tripathi; Geetanjali Murari
Journal:  Biol Psychiatry       Date:  2015-04-14       Impact factor: 13.382

5.  TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys.

Authors:  Mychael V Lourenco; Julia R Clarke; Rudimar L Frozza; Theresa R Bomfim; Letícia Forny-Germano; André F Batista; Luciana B Sathler; Jordano Brito-Moreira; Olavo B Amaral; Cesar A Silva; Léo Freitas-Correa; Sheila Espírito-Santo; Paula Campello-Costa; Jean-Christophe Houzel; William L Klein; Christian Holscher; José B Carvalheira; Aristobolo M Silva; Lício A Velloso; Douglas P Munoz; Sergio T Ferreira; Fernanda G De Felice
Journal:  Cell Metab       Date:  2013-12-03       Impact factor: 27.287

6.  Alterations of cholesterol precursor levels in Alzheimer's disease.

Authors:  Heike Kölsch; Reinhard Heun; Frank Jessen; Julius Popp; Frank Hentschel; Wolfgang Maier; Dieter Lütjohann
Journal:  Biochim Biophys Acta       Date:  2010-03-11

7.  Vitamin E and donepezil for the treatment of mild cognitive impairment.

Authors:  Ronald C Petersen; Ronald G Thomas; Michael Grundman; David Bennett; Rachelle Doody; Steven Ferris; Douglas Galasko; Shelia Jin; Jeffrey Kaye; Allan Levey; Eric Pfeiffer; Mary Sano; Christopher H van Dyck; Leon J Thal
Journal:  N Engl J Med       Date:  2005-04-13       Impact factor: 91.245

8.  Insulin Regulates Astrocytic Glucose Handling Through Cooperation With IGF-I.

Authors:  Ana M Fernandez; Edwin Hernandez-Garzón; Paloma Perez-Domper; Alberto Perez-Alvarez; Sara Mederos; Takashi Matsui; Andrea Santi; Angel Trueba-Saiz; Lucía García-Guerra; Julia Pose-Utrilla; Jens Fielitz; Eric N Olson; Ruben Fernandez de la Rosa; Luis Garcia Garcia; Miguel Angel Pozo; Teresa Iglesias; Alfonso Araque; Hideaki Soya; Gertrudis Perea; Eduardo D Martin; Ignacio Torres Aleman
Journal:  Diabetes       Date:  2016-10-10       Impact factor: 9.461

9.  Heme oxygenase-1 posttranslational modifications in the brain of subjects with Alzheimer disease and mild cognitive impairment.

Authors:  Eugenio Barone; Fabio Di Domenico; Rukhsana Sultana; Raffaella Coccia; Cesare Mancuso; Marzia Perluigi; D Allan Butterfield
Journal:  Free Radic Biol Med       Date:  2012-04-17       Impact factor: 7.376

10.  Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation.

Authors:  Markus Schubert; Derek P Brazil; Deborah J Burks; Jake A Kushner; Jing Ye; Carrie L Flint; Janet Farhang-Fallah; Pieter Dikkes; Xavier M Warot; Carlos Rio; Gabriel Corfas; Morris F White
Journal:  J Neurosci       Date:  2003-08-06       Impact factor: 6.167
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  5 in total

Review 1.  Utility of Animal Models to Understand Human Alzheimer's Disease, Using the Mastermind Research Approach to Avoid Unnecessary Further Sacrifices of Animals.

Authors:  Tian Qin; Samantha Prins; Geert Jan Groeneveld; Gerard Van Westen; Helga E de Vries; Yin Cheong Wong; Luc J M Bischoff; Elizabeth C M de Lange
Journal:  Int J Mol Sci       Date:  2020-04-30       Impact factor: 5.923

Review 2.  The role of DHCR24 in the pathogenesis of AD: re-cognition of the relationship between cholesterol and AD pathogenesis.

Authors:  Xiaojing Bai; Meiting Mai; Kai Yao; Mengqi Zhang; Yue Huang; Wenbin Zhang; Xiaorou Guo; Yixuan Xu; Ying Zhang; Atikam Qurban; Lijie Duan; Jimei Bu; Jianfeng Zhang; Junfeng Wu; Yongfei Zhao; Xiangshan Yuan; Hengbing Zu
Journal:  Acta Neuropathol Commun       Date:  2022-03-16       Impact factor: 7.578

3.  Mitigation of Memory Impairment with Fermented Fucoidan and λ-Carrageenan Supplementation through Modulating the Gut Microbiota and Their Metagenome Function in Hippocampal Amyloid-β Infused Rats.

Authors:  Ting Zhang; Xuangao Wu; Heng Yuan; Shaokai Huang; Sunmin Park
Journal:  Cells       Date:  2022-07-26       Impact factor: 7.666

Review 4.  Mens Sana in Corpore Sano: Does the Glycemic Index Have a Role to Play?

Authors:  Lionel Carneiro; Corinne Leloup
Journal:  Nutrients       Date:  2020-09-29       Impact factor: 5.717

Review 5.  Inflammasome NLRP3 Potentially Links Obesity-Associated Low-Grade Systemic Inflammation and Insulin Resistance with Alzheimer's Disease.

Authors:  Anna Litwiniuk; Wojciech Bik; Małgorzata Kalisz; Agnieszka Baranowska-Bik
Journal:  Int J Mol Sci       Date:  2021-05-25       Impact factor: 5.923
  5 in total

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