BACKGROUND: We aim to investigate the prognostic implications of synchronous skip metastases in osteosarcoma by presenting the largest single centre series to date. METHODS: Retrospective study of 21 osteosarcoma patients with skip metastases treated between 1983 and 2004. RESULTS: No statistical difference in overall survival was demonstrated when comparing presence of lung metastases to those without (p = 0.859). No statistical difference was found in overall survival according to age group (<18yrs vs >18yrs; p = 0.126), or to percentage chemotherapy-induced bone necrosis (<90% vs >90%; p = 0.056). CONCLUSIONS: The presence of skip metastases confers a very poor prognosis as an independent variable. LEVEL OF EVIDENCE: III.
BACKGROUND: We aim to investigate the prognostic implications of synchronous skip metastases in osteosarcoma by presenting the largest single centre series to date. METHODS: Retrospective study of 21 osteosarcoma patients with skip metastases treated between 1983 and 2004. RESULTS: No statistical difference in overall survival was demonstrated when comparing presence of lung metastases to those without (p = 0.859). No statistical difference was found in overall survival according to age group (<18yrs vs >18yrs; p = 0.126), or to percentage chemotherapy-induced bone necrosis (<90% vs >90%; p = 0.056). CONCLUSIONS: The presence of skip metastases confers a very poor prognosis as an independent variable. LEVEL OF EVIDENCE: III.
Authors: D M Panicek; C Gatsonis; D I Rosenthal; L L Seeger; A G Huvos; S G Moore; D J Caudry; W E Palmer; B J McNeil Journal: Radiology Date: 1997-01 Impact factor: 11.105
Authors: Kaveh R Sajadi; Robert K Heck; Michael D Neel; Bhaskar N Rao; Najat Daw; Carlos Rodriguez-Galindo; Fredric A Hoffer; G Scott Stacy; Terrance D Peabody; Michael A Simon Journal: Clin Orthop Relat Res Date: 2004-09 Impact factor: 4.176
Authors: Robert Grimer; Nick Athanasou; Craig Gerrand; Ian Judson; Ian Lewis; Bruce Morland; David Peake; Beatrice Seddon; Jeremy Whelan Journal: Sarcoma Date: 2010-12-29