Cristian Navarrete-Dechent1,2, Saud Aleissa2, Miguel Cordova2, Konstantinos Liopyris2,3, Aditi Sahu2, Anthony M Rossi2, Erica H Lee2, Kishwer S Nehal4. 1. Department of Dermatology, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile. 2. Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 16 E 60th Street, New York, NY, USA. 3. University of Athens, Athens, Greece. 4. Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 16 E 60th Street, New York, NY, USA. nehalk@mskcc.org.
Abstract
INTRODUCTION: Recently, a combined reflectance confocal microscopy (RCM)-optical coherence tomography (OCT) has been tested for the diagnosis of basal cell carcinoma (BCC). Evaluating the role of RCM-OCT in management of complex BCCs has not been studied. The objective of the study was to investigate the utility of a new combined RCM-OCT device in the evaluation and management of complex BCCs in a descriptive study. METHODS: Prospective study of consecutive cases (July 2018-June 2019) of biopsy-proven 'complex' BCC defined as BCC in the head-and-neck area with multiple high-risk criteria such as large size in the mask area, multiple recurrences, and high-risk subtype. All cases were evaluated with a combined RCM-OCT device that provided simultaneous image viewing on a screen. Lesions were evaluated bedside with RCM-OCT according to previously described criteria. RESULTS: Ten patients with complex head-and-neck BCCs had mean age of 73.1 ± 13.0 years. Six (60%) patients were males. Mean BCC clinical size was 1.9 ± 1.2 cm (range 0.6-4.0 cm). RCM detected residual BCC in 8 out of 10 cases (80%) and OCT detected residual BCC in all 10 cases (100%). Six BCCs (60%) had a depth estimate of > 1000 µm under OCT. In five cases, (50%) RCM-OCT imaging results led to a change/modification in BCC management. CONCLUSION: The use of a combined RCM-OCT device may help in the evaluation of complex head-and-neck BCCs by guiding treatment selection and defining the extent of surgery.
INTRODUCTION: Recently, a combined reflectance confocal microscopy (RCM)-optical coherence tomography (OCT) has been tested for the diagnosis of basal cell carcinoma (BCC). Evaluating the role of RCM-OCT in management of complex BCCs has not been studied. The objective of the study was to investigate the utility of a new combined RCM-OCT device in the evaluation and management of complex BCCs in a descriptive study. METHODS: Prospective study of consecutive cases (July 2018-June 2019) of biopsy-proven 'complex' BCC defined as BCC in the head-and-neck area with multiple high-risk criteria such as large size in the mask area, multiple recurrences, and high-risk subtype. All cases were evaluated with a combined RCM-OCT device that provided simultaneous image viewing on a screen. Lesions were evaluated bedside with RCM-OCT according to previously described criteria. RESULTS: Ten patients with complex head-and-neck BCCs had mean age of 73.1 ± 13.0 years. Six (60%) patients were males. Mean BCC clinical size was 1.9 ± 1.2 cm (range 0.6-4.0 cm). RCM detected residual BCC in 8 out of 10 cases (80%) and OCT detected residual BCC in all 10 cases (100%). Six BCCs (60%) had a depth estimate of > 1000 µm under OCT. In five cases, (50%) RCM-OCT imaging results led to a change/modification in BCC management. CONCLUSION: The use of a combined RCM-OCT device may help in the evaluation of complex head-and-neck BCCs by guiding treatment selection and defining the extent of surgery.
Authors: Cristian Navarrete-Dechent; Miguel Cordova; Saud Aleissa; Konstantinos Liopyris; Stephen W Dusza; William Phillips; Anthony M Rossi; Erica H Lee; Ashfaq A Marghoob; Kishwer S Nehal Journal: J Am Acad Dermatol Date: 2019-06-19 Impact factor: 11.527
Authors: Cristian Navarrete-Dechent; Miguel Cordova; Saud Aleissa; Kivanc Kose; Erica H Lee; Anthony M Rossi; Kishwer S Nehal Journal: J Am Acad Dermatol Date: 2019-07-19 Impact factor: 11.527
Authors: Cristian Navarrete-Dechent; Antonio P DeRosa; Caterina Longo; Konstantinos Liopyris; Margaret Oliviero; Harold Rabinovitz; Ashfaq A Marghoob; Allan C Halpern; Giovanni Pellacani; Alon Scope; Manu Jain Journal: J Am Acad Dermatol Date: 2018-12-08 Impact factor: 11.527
Authors: Cristian Navarrete-Dechent; Miguel Cordova; Saud Aleissa; Konstantinos Liopyris; Stephen W Dusza; Kivanc Kose; Klaus J Busam; Travis Hollman; Cecilia Lezcano; Melissa Pulitzer; Chih-Shan J Chen; Erica H Lee; Anthony M Rossi; Kishwer S Nehal Journal: J Am Acad Dermatol Date: 2019-12-05 Impact factor: 11.527
Authors: Milind Rajadhyaksha; Ashfaq Marghoob; Anthony Rossi; Allan C Halpern; Kishwer S Nehal Journal: Lasers Surg Med Date: 2016-10-27 Impact factor: 4.025
Authors: Matti Sievert; Marc Aubreville; Antoniu-Oreste Gostian; Konstantinos Mantsopoulos; Michael Koch; Sarina Katrin Mueller; Markus Eckstein; Robin Rupp; Florian Stelzle; Nicolai Oetter; Andreas Maier; Heinrich Iro; Miguel Goncalves Journal: Eur Arch Otorhinolaryngol Date: 2022-02-28 Impact factor: 3.236