Caterina Longo1, Aimilios Lallas2, Athanassios Kyrgidis2, Harold Rabinovitz3, Elvira Moscarella2, Silvana Ciardo4, Iris Zalaudek5, Margaret Oliviero3, Amanda Losi4, Salvador Gonzalez6, Pascale Guitera7, Simonetta Piana8, Giuseppe Argenziano2, Giovanni Pellacani4. 1. Dermatology and Skin Cancer Unit, Arcispedale S. Maria Nuova, IRCCS, Reggio Emilia, Italy. Electronic address: longo.caterina@gmail.com. 2. Dermatology and Skin Cancer Unit, Arcispedale S. Maria Nuova, IRCCS, Reggio Emilia, Italy. 3. Skin and Cancer Associates, Plantation, Florida. 4. Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy. 5. Dermatology and Skin Cancer Unit, Arcispedale S. Maria Nuova, IRCCS, Reggio Emilia, Italy; Department of Dermatology, Medical University of Graz, Graz, Austria. 6. Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, New York. 7. Melanoma Institute Australia, The University of Sydney and Sydney Melanoma Diagnostic Centre, Royal Prince Alfred Hospital, Sydney, Australia. 8. Pathology Unit, Arcispedale S. Maria Nuova, IRCCS, Reggio Emilia, Italy.
Abstract
BACKGROUND: The current guidelines for the management of basal cell carcinoma (BCC) suggest a different therapeutic approach according to histopathologic subtype. Although dermatoscopic and confocal criteria of BCC have been investigated, no specific studies were performed to evaluate the distinct reflectance confocal microscopy (RCM) aspects of BCC subtypes. OBJECTIVES: To define the specific dermatoscopic and confocal criteria for delineating different BCC subtypes. METHODS: Dermatoscopic and confocal images of histopathologically confirmed BCCs were retrospectively evaluated for the presence of predefined criteria. Frequencies of dermatoscopic and confocal parameters are provided. Univariate and adjusted odds ratios were calculated. Discriminant analyses were performed to define the independent confocal criteria for distinct BCC subtypes. RESULTS: Eighty-eight BCCs were included. Dermatoscopically, superficial BCCs (n=44) were primarily typified by the presence of fine telangiectasia, multiple erosions, leaf-like structures, and revealed cords connected to the epidermis and epidermal streaming upon RCM. Nodular BCCs (n=22) featured the classic dermatoscopic features and well outlined large basaloid islands upon RCM. Infiltrative BCCs (n=22) featured structureless, shiny red areas, fine telangiectasia, and arborizing vessels on dermatoscopy and dark silhouettes upon RCM. LIMITATIONS: The retrospective design. CONCLUSION: Dermatoscopy and confocal microscopy can reliably classify different BCC subtypes.
BACKGROUND: The current guidelines for the management of basal cell carcinoma (BCC) suggest a different therapeutic approach according to histopathologic subtype. Although dermatoscopic and confocal criteria of BCC have been investigated, no specific studies were performed to evaluate the distinct reflectance confocal microscopy (RCM) aspects of BCC subtypes. OBJECTIVES: To define the specific dermatoscopic and confocal criteria for delineating different BCC subtypes. METHODS: Dermatoscopic and confocal images of histopathologically confirmed BCCs were retrospectively evaluated for the presence of predefined criteria. Frequencies of dermatoscopic and confocal parameters are provided. Univariate and adjusted odds ratios were calculated. Discriminant analyses were performed to define the independent confocal criteria for distinct BCC subtypes. RESULTS: Eighty-eight BCCs were included. Dermatoscopically, superficial BCCs (n=44) were primarily typified by the presence of fine telangiectasia, multiple erosions, leaf-like structures, and revealed cords connected to the epidermis and epidermal streaming upon RCM. Nodular BCCs (n=22) featured the classic dermatoscopic features and well outlined large basaloid islands upon RCM. Infiltrative BCCs (n=22) featured structureless, shiny red areas, fine telangiectasia, and arborizing vessels on dermatoscopy and dark silhouettes upon RCM. LIMITATIONS: The retrospective design. CONCLUSION: Dermatoscopy and confocal microscopy can reliably classify different BCC subtypes.
Authors: Mihaela Balu; Christopher B Zachary; Ronald M Harris; Tatiana B Krasieva; Karsten König; Bruce J Tromberg; Kristen M Kelly Journal: JAMA Dermatol Date: 2015-10 Impact factor: 10.282
Authors: Anna Pogorzelska-Antkowiak; SŁawomir Grzegorczyn; Paola Corneli; Jacek C Szepietowski Journal: In Vivo Date: 2021 Jan-Feb Impact factor: 2.155
Authors: Saud Aleissa; Cristian Navarrete-Dechent; Miguel Cordova; Aditi Sahu; Stephen W Dusza; William Phillips; Anthony Rossi; Erica Lee; Kishwer S Nehal Journal: J Am Acad Dermatol Date: 2019-10-18 Impact factor: 11.527
Authors: Cristian Navarrete-Dechent; Konstantinos Liopyris; Ayelet Rishpon; Nadeem G Marghoob; Miguel Cordova; Stephen W Dusza; Aditi Sahu; Kivanc Kose; Margaret Oliviero; Harold Rabinovitz; Klaus J Busam; Michael A Marchetti; Chih-Chan J Chen; Ashfaq A Marghoob Journal: JAMA Dermatol Date: 2020-08-01 Impact factor: 10.282