PURPOSE: This study aimed to analyze the demographics, clinicopathological, treatment, and survival characteristics of head and neck sarcomas diagnosed in a reference center in the Brazilian Northeast. MATERIALS AND METHODS: This retrospective cohort study reviewed the clinical records of patients with head and neck sarcomas. Epidemiologic data consisted in clinical location, age, gender, histopathological diagnosis, clinical TNM staging and treatment. Outcome variables were local recurrence and survival. The statistical analyses were performed by a binary logistic regression analysis. The survival analysis was assessed through the Kaplan-Meier curve. RESULTS: Sixty-nine patients with head and neck sarcomas (male 39; female 30) were analyzed. The most common histologic subtypes were rhabdomyosarcoma, dermatofibrosarcoma, and pleomorphic sarcoma. The mean age of the patients at the time of diagnosis was 38.1 years old. A total of 31 patient died (sarcoma-related death) up to the end of the follow-up, with a mean follow-up rate of 1.63 years. A multivariate analysis revealed that anatomical site, treatment modality, histopathological diagnosis, and clinical stage of the disease were associated with specific survival, reaching statistical significance. CONCLUSION: This study demonstrates the impact of important clinical-pathological parameters on the overall prognosis of head and neck sarcomas.
PURPOSE: This study aimed to analyze the demographics, clinicopathological, treatment, and survival characteristics of head and neck sarcomas diagnosed in a reference center in the Brazilian Northeast. MATERIALS AND METHODS: This retrospective cohort study reviewed the clinical records of patients with head and neck sarcomas. Epidemiologic data consisted in clinical location, age, gender, histopathological diagnosis, clinical TNM staging and treatment. Outcome variables were local recurrence and survival. The statistical analyses were performed by a binary logistic regression analysis. The survival analysis was assessed through the Kaplan-Meier curve. RESULTS: Sixty-nine patients with head and neck sarcomas (male 39; female 30) were analyzed. The most common histologic subtypes were rhabdomyosarcoma, dermatofibrosarcoma, and pleomorphic sarcoma. The mean age of the patients at the time of diagnosis was 38.1 years old. A total of 31 patient died (sarcoma-related death) up to the end of the follow-up, with a mean follow-up rate of 1.63 years. A multivariate analysis revealed that anatomical site, treatment modality, histopathological diagnosis, and clinical stage of the disease were associated with specific survival, reaching statistical significance. CONCLUSION: This study demonstrates the impact of important clinical-pathological parameters on the overall prognosis of head and neck sarcomas.
Entities:
Keywords:
Head and neck sarcomas; Histologic types; Prognosis; Treatment
Authors: D Mattavelli; R Miceli; S Radaelli; F Mattavelli; G Cantù; M Barisella; P Quattrone; S Stacchiotti; C Sangalli; P G Casali; A Gronchi; M Fiore Journal: Ann Oncol Date: 2013-04-05 Impact factor: 32.976
Authors: J M Coindre; M Trojani; G Contesso; M David; J Rouesse; N B Bui; A Bodaert; I De Mascarel; A De Mascarel; J F Goussot Journal: Cancer Date: 1986-07-15 Impact factor: 6.860
Authors: Gabriela Ribeiro de Araújo; Sara Ferreira Dos Santos Costa; Ricardo Alves Mesquita; Ricardo Santiago Gomez; Jean Nunes Dos Santos; Hélder Antônio Rebelo Pontes; Bruno Augusto Benevenuto de Andrade; Mário José Romañach; Michelle Agostini; Pablo Agustin Vargas; Cinthia Verônica Bardalez Lopez de Cáceres; Alan Roger Santos-Silva; Ana Carolina Prado Ribeiro; Thaís Bianca Brandão; Ramiro Alejandro Tomasi; Ruth Salomé Ferreyra; Oslei Paes de Almeida; Felipe Paiva Fonseca Journal: Head Neck Pathol Date: 2021-06-09