Rosa Angélica Salcedo-Hernández1, Leonardo Saúl Lino-Silva2, Adalberto Mosqueda-Taylor3, Kuauhyama Luna-Ortiz1. 1. Department of Surgical Oncology at the Instituto Nacional de Cancerologia, México, D.F. Av San Fernando #22 col. Seccion XVI, Tlalpan, Mexico City CP 14080, Mexico. 2. Department of Anatomic Pathology, Hospital y Fundación Clínica Médica Sur, Mexico City, Mexico. Electronic address: saul.lino.sil@gmail.com. 3. Department of Head and Neck Surgery at the Instituto Nacional de Cancerologia, México, D.F. Av San Fernando #22 col. Seccion XVI, Tlalpan, Mexico City CP 14080, Mexico; Departamento de Atención a la Salud, Universidad Autónoma Metropolitana Xochimilco, Mexico City, Mexico.
Abstract
BACKGROUND: Sarcomas constitute 1% of all malignancies, but 10% occur in the head and neck (HN), and they are poorly understood. We present a large series of Soft Tissue HN sarcomas in Mexican patients with survival analysis. STUDY DESIGN: This is a retrospective study of cases in a cancer hospital. METHODS: Review of files and pathology material. Literature review. RESULTS: We analysed 108 patients (55 men / 53 women). The age at presentation was 37 years. The original diagnosis changed in nine cases (8.3%). The most common subtype was rhabdomyosarcoma. Ninety percent of tumours were deep, 91% were high grade, 44% had metastasis, 63% measured >5 cm, overall 5-year survival (5 y-OS) was 48%, and histological high grade was associated with poor survival (p = 0.026). CONCLUSION: Sarcomas of the HN are rare. The most affected sites were paranasal sinuses. The majority of tumours were deep, > 5 cm and high grade, 50% had metastasis, the 5 y-OS was 48% and the only independent factor associated with 5 y-OS was histologic grade.
BACKGROUND:Sarcomas constitute 1% of all malignancies, but 10% occur in the head and neck (HN), and they are poorly understood. We present a large series of Soft Tissue HN sarcomas in Mexican patients with survival analysis. STUDY DESIGN: This is a retrospective study of cases in a cancer hospital. METHODS: Review of files and pathology material. Literature review. RESULTS: We analysed 108 patients (55 men / 53 women). The age at presentation was 37 years. The original diagnosis changed in nine cases (8.3%). The most common subtype was rhabdomyosarcoma. Ninety percent of tumours were deep, 91% were high grade, 44% had metastasis, 63% measured >5 cm, overall 5-year survival (5 y-OS) was 48%, and histological high grade was associated with poor survival (p = 0.026). CONCLUSION:Sarcomas of the HN are rare. The most affected sites were paranasal sinuses. The majority of tumours were deep, > 5 cm and high grade, 50% had metastasis, the 5 y-OS was 48% and the only independent factor associated with 5 y-OS was histologic grade.