Literature DB >> 3201255

Development of disease and virus recovery in transgenic mice containing HIV proviral DNA.

J M Leonard1, J W Abramczuk, D S Pezen, R Rutledge, J H Belcher, F Hakim, G Shearer, L Lamperth, W Travis, T Fredrickson.   

Abstract

Transgenic mice containing intact copies of the human immunodeficiency virus (HIV) proviral DNA were constructed. Founder animals were not viremic for HIV and remained healthy during a 9-month observation period. After being mated with nontransgenic animals, one founder mouse (No. 13) gave rise to F1 progeny that developed a disease syndrome characterized by marked epidermal hyperplasia, lymphadenopathy, splenomegaly, pulmonary lymphoid infiltrates, growth retardation, and death by day 25 of life. Infectious HIV, indistinguishable from parental virus by immunoblot analysis, was recovered from the spleen, lymph nodes, and skin of five of five affected animals.

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Year:  1988        PMID： 3201255     DOI： 10.1126/science.3201255

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  42 in total

Review 1.  Genetic knockouts suggest a critical role for HIV co-receptors in models of HIV gp120-induced brain injury.

Authors:  Ricky Maung; Kathryn E Medders; Natalia E Sejbuk; Maya K Desai; Rossella Russo; Marcus Kaul
Journal:  J Neuroimmune Pharmacol       Date:  2011-11-29       Impact factor: 4.147

2.  CD4-specific transgenic expression of human cyclin T1 markedly increases human immunodeficiency virus type 1 (HIV-1) production by CD4+ T lymphocytes and myeloid cells in mice transgenic for a provirus encoding a monocyte-tropic HIV-1 isolate.

Authors:  Jinglin Sun; Timothy Soos; Vineet N Kewalramani; Kristin Osiecki; Jian Hua Zheng; Laurie Falkin; Laura Santambrogio; Dan R Littman; Harris Goldstein
Journal:  J Virol       Date:  2006-02       Impact factor: 5.103

Review 3.  Immunopathogenesis of oropharyngeal candidiasis in human immunodeficiency virus infection.

Authors:  Louis de Repentigny; Daniel Lewandowski; Paul Jolicoeur
Journal:  Clin Microbiol Rev       Date:  2004-10       Impact factor: 26.132

4.  Interactions of the transcription factor AP-1 with the long terminal repeat of different human immunodeficiency virus type 1 strains in Jurkat, glial, and neuronal cells.

Authors:  F Canonne-Hergaux; D Aunis; E Schaeffer
Journal:  J Virol       Date:  1995-11       Impact factor: 5.103

5.  Expression of a human immunodeficiency virus type 1 long terminal repeat/simian virus 40 early region fusion gene in transgenic mice.

Authors:  J Skowronski
Journal:  J Virol       Date:  1991-02       Impact factor: 5.103

6.  FVB/N: an inbred mouse strain preferable for transgenic analyses.

Authors:  M Taketo; A C Schroeder; L E Mobraaten; K B Gunning; G Hanten; R R Fox; T H Roderick; C L Stewart; F Lilly; C T Hansen
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-15       Impact factor: 11.205

7.  Progressive glomerulosclerosis and enhanced renal accumulation of basement membrane components in mice transgenic for human immunodeficiency virus type 1 genes.

Authors:  J B Kopp; M E Klotman; S H Adler; L A Bruggeman; P Dickie; N J Marinos; M Eckhaus; J L Bryant; A L Notkins; P E Klotman
Journal:  Proc Natl Acad Sci U S A       Date:  1992-03-01       Impact factor: 11.205

8.  Serological, biological, and molecular characterization of New Zealand white rabbits infected by intraperitoneal inoculation with cell-free human immunodeficiency virus.

Authors:  S Reina; P Markham; E Gard; F Rayed; M Reitz; R C Gallo; O E Varnier
Journal:  J Virol       Date:  1993-09       Impact factor: 5.103

Review 9.  Transgenic and knockout mice in the study of neurodegenerative diseases.

Authors:  A Aguzzi; S Brandner; S Marino; J P Steinbach
Journal:  J Mol Med (Berl)       Date:  1996-03       Impact factor: 4.599

Review 10.  Animal models for HIV/AIDS research.

Authors:  Theodora Hatziioannou; David T Evans
Journal:  Nat Rev Microbiol       Date:  2012-12       Impact factor: 60.633
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