Hiren Mandaliya1,2, Mark Jones3, Christopher Oldmeadow2,3, Ina Ic Nordman1,2. 1. Medical Oncology, Calvary Mater Newcastle, Waratah, NSW, Australia. 2. School of Medicine and Public Health, University of Newcastle, Australia. 3. Hunter Medical Research Institute, Newcastle, NSW, Australia.
Abstract
BACKGROUND: Currently, there is no single validated biomarker which can prognosticate survival in patients with stage IV non-small cell lung cancer (NSCLC). This study examines the prognostic significance of four biomarkers: neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), platelet to lymphocyte ratio (PLR) and advanced lung cancer inflammation index (ALI) in patients with stage IV NSCLC. METHODS: This study aimed to establish the relationship between NLR, LMR, PLR, ALI and overall survival (OS) at baseline and post first cycle of treatment using Cox univariate PH models. We also studied these biomarkers in the elderly (age ≥70 years). Clinical data was sourced from Calvary Mater Newcastle between 2010 and 2015. RESULTS: Baseline NLR, PLR, LMR and ALI showed strong association with OS. Five unit increase in NLR and PLR was associated with an 11% and 0.5% increase in the hazard of death respectively while 1 unit increase in ALI resulted in 4% increase in hazard of death. Five unit increase in LMR was associated with a 50% reduction in hazard of death. Post-treatment NLR and low ALI correlated with shorter OS but no statistically significant relationship could be demonstrated for PLR nor LMR. Similar prognostic trends were noted for elderly. CONCLUSIONS: High NLR, high PLR, low LMR and low ALI at baseline are significantly associated with poor OS. High NLR and low ALI are significantly associated with poor OS post treatment. Findings are similar regardless of age. 2019 Translational Lung Cancer Research. All rights reserved.
BACKGROUND: Currently, there is no single validated biomarker which can prognosticate survival in patients with stage IV non-small cell lung cancer (NSCLC). This study examines the prognostic significance of four biomarkers: neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), platelet to lymphocyte ratio (PLR) and advanced lung cancer inflammation index (ALI) in patients with stage IV NSCLC. METHODS: This study aimed to establish the relationship between NLR, LMR, PLR, ALI and overall survival (OS) at baseline and post first cycle of treatment using Cox univariate PH models. We also studied these biomarkers in the elderly (age ≥70 years). Clinical data was sourced from Calvary Mater Newcastle between 2010 and 2015. RESULTS: Baseline NLR, PLR, LMR and ALI showed strong association with OS. Five unit increase in NLR and PLR was associated with an 11% and 0.5% increase in the hazard of death respectively while 1 unit increase in ALI resulted in 4% increase in hazard of death. Five unit increase in LMR was associated with a 50% reduction in hazard of death. Post-treatment NLR and low ALI correlated with shorter OS but no statistically significant relationship could be demonstrated for PLR nor LMR. Similar prognostic trends were noted for elderly. CONCLUSIONS: High NLR, high PLR, low LMR and low ALI at baseline are significantly associated with poor OS. High NLR and low ALI are significantly associated with poor OS post treatment. Findings are similar regardless of age. 2019 Translational Lung Cancer Research. All rights reserved.
Authors: S Cedrés; D Torrejon; A Martínez; P Martinez; A Navarro; E Zamora; N Mulet-Margalef; E Felip Journal: Clin Transl Oncol Date: 2012-07-19 Impact factor: 3.405
Authors: Anna Cho; Helena Untersteiner; Fabian Fitschek; Farjad Khalaveh; Philip Pruckner; Noemi Pavo; Karl Rössler; Christian Dorfer; Brigitte Gatterbauer; Christoph Höller; Manuela Schmidinger; Josa M Frischer Journal: J Neurooncol Date: 2021-06-20 Impact factor: 4.130