Association of Sedentary Time and Physical Activity with the 10-Year Risk of Cardiovascular Disease: Korea National Health and Nutrition Examination Survey 2014-2017.

BACKGROUND: Sedentary behavior is associated with increased cardiovascular disease (CVD) risk. We investigated this association of sedentary time and physical activity with increased 10-year CVD risk in Korean adults.
METHODS: This cross-sectional study used data from the Korea National Health and Nutrition Examination Survey (2014-2017). In total, 14,551 participants aged 30-74 years (6,323 men, 8,228 women) were analyzed. The usual length of sedentary time per day was categorized into three groups (<6, 6-<9, or ≥9 h/d), and physical activity (metabolic equivalents [METs]∙min/wk) was categorized into two groups (low, <600 METs∙min/wk; moderate/high, ≥600 METs∙min/wk). Logistic regression analysis was performed to assess the association between sedentary time and increased CVD risk (predicted 10-year risk ≥10%). Adjusted variables were age, sex, body mass index, marital status, employment, household income, alcohol use, family history of CVD, and comorbidity (hypertension, diabetes, and dyslipidemia).
RESULTS: The average sedentary time for the 14,551 participants was 7.49 h/d, with an average 10-year CVD risk of 9.58%. There was no significant association between sedentary time and increased 10-year CVD risk in the moderate/ high physical activity group. In the low physical activity group, sedentary time ≥9 h/d had a significant association with increased CVD risk (odds ratio [OR], 1.29; 95% confidence interval [CI], 1.04-1.62). However, when the sedentary time was <6 h/d, no significant associations were found (OR, 1.17; 95% CI, 0.92-1.49).
CONCLUSION: In the low physical activity group, reduction of sedentary time might be important for preventing increased CVD risk.

INTRODUCTION

One in four people worldwide is not sufficiently physically active [1]. The World Health Organization (WHO) identifies insufficient physical activity as a major risk factor for death globally and a key risk factor for noncommunicable diseases such as cancer, diabetes mellitus, and cardiovascular disease (CVD). Physical activity contributes toward health improvement and prevention of noncommunicable diseases [1], whereas sedentary behavior is related to deleterious health outcomes such as all-cause mortality, CVD mortality and incidence, and cancer mortality and incidence [2]. Sedentary behavior is commonly defined as “any waking behavior characterized by an energy expenditure ≤1.5 metabolic equivalents (METs) while in a sitting or reclining posture.” [3]

According to statistics released by Statistics Korea in 2017, heart and cerebrovascular diseases are the second and the third most common cause of deaths, respectively [4]. Several studies have been conducted to predict the incidence of CVD as it is a major cause of death not only in Korea but also worldwide.

Several studies have investigated the association between sedentary behavior and CVD. Until recently, the association between sedentary time and CVD has been a controversial issue. Increasing evidence has shown that prolonged sedentary time is independently associated with CVD-related mortality and incidence, regardless of physical activity [2,5-9].

In this study, we examined associations between sedentary time and 10-year CVD risk in different physical activity groups and aimed to determine the importance of sedentary time, with the assumption that it is an important factor for increased 10-year CVD risk within the same physical activity group and even among different groups according to physical activity level.

METHODS

1. Participants

In this cross-sectional study, data were obtained from the Korea National Health and Nutrition Examination Survey between 2014 and 2017 (KNHANES VI-VII). The KNHANES is a nationwide, populationbased survey in the Republic of Korea that was designed to collect information on the nutritional and health status, sociodemographic status, and health behaviors of Koreans. Data from health interviews and examination surveys of KNHANES were used for the analysis.

Among the 31,207 individuals who participated in KNHANES between 2014 and 2017, we included participants aged 30–74 years in this study because the Framingham risk score could be used to predict CVD risk at these ages [10]. We excluded patients who were diagnosed with any cancer (n=899), stroke, angina, or myocardial infarction (n=712). Pregnant women (n=106) and those who had no information on sitting time (n=2,375) or physical activity (n=2) were also excluded. Data from 14,551 participants were available for this analysis. The study protocol was approved by the Seoul National University Hospital Institutional Review Board (approval no., E-1908-068-1054), and the need for informed consent was waived, as the subjects’records and informations were anonymized and de-identified prior to analysis.

2. Measurements

1) Sedentary time and physical activity

Sedentary time and physical activity were defined and evaluated using the Global Physical Activity Questionnaire (GPAQ) [11,12], proposed by the WHO as a self-written health questionnaire. The GPAQ consists of 16 questions on occupational physical activity, leisure-time physical activity, commuting physical activity, and sedentary behavior. The reliability and validity of its Korean version have been verified [13].

The following questions were used to assess the sedentary time: “Except for sleeping time, how much time do you usually spend sitting or reclining on a typical day?” Previous studies have reported that a sedentary time of >8 and 10 hours was associated with CVD risk [14,15].

Based on the fact that the average sedentary time of all participants in this study was 7.49 hours, we set 6 and 9 hours, which are about 1.5 hours apart from 7.49 hours, as the basis for the classification of sedentary time. The total sedentary time in hours per day (h/d) was used as a categorical variable and divided into three categories (<6, 6–<9, and ≥9 h/d).

To define physical activity, we used the GPAQ questionnaire on occupational and leisure-time physical activity. In the questions, “vigorous-intensity activities” are activities that require hard physical effort and cause large increases in breathing or heart rate, whereas “moderate-intensity activities” are those that require moderate physical effort and cause small increases in breathing or heart rate. In this study, commuting physical activity in the GPAQ questionnaire was not used. Instead, the questions “How many days have you walked at least 10 minutes at a time in the last week?” and “How many hours do you usually walk per day?” were used for further assessment of walking as a physical activity [16].

METs are commonly used to express the intensity of physical activities. One MET is defined as the amount of oxygen consumed while sitting at rest and is equal to 3.5 mL O2 per 1 kg body weight∙min. Moreover, it is equivalent to a caloric consumption of 1 kcal/kg/h. The total physical activity is expressed as METs∙min/wk and categorized into three groups according to the total physical activity level based on the GPAQ analysis guideline (low, moderate, or high) [17]. We applied 8.0 METs to vigorous-intensity activities, 4.0 METs to moderate-intensity activities [17], and 3.3 METs to walking [16]. Thereafter, we classified the activity groups based on the WHO-recommended minimum level of 600 METs∙min/wk [18]. The “low” activity group was the group with the lowest total physical activity (<600 METs∙min/wk), the “moderate” activity group achieved at least 600 METs∙min/wk but <3,000 METs∙min/wk, and the “high” activity group achieved at least 3,000 METs∙min/wk [17]. We integrated the moderate and high activity groups for the analysis.

Further, six sedentary lifestyle groups were created using the sedentary time and physical activity as combined variables, in which the lowest sedentary time (<6 h/d) and moderate/high physical activity (≥600 METs∙min/wk) served as the reference category (group 1).

2) Estimation of the 10-year CVD risk based on the Framingham Heart Study

The “Framingham Heart Study 10-year CVD risk calculator” was used to calculate the 10-year CVD risk prediction value using the following parameters: sex (categorical, male or female), age (continuous, years), systolic blood pressure (continuous, mm Hg), high-density lipoprotein level (continuous, mg/dL), total cholesterol level (continuous, mg/dL), presence of diabetes mellitus (categorical, yes or no), whether or not hypertension is currently treated, and current smoking status (categorical, current smoker or current non-smoker) [19].

The 10-year CVD risk was categorized as low- (<10%), intermediate- (≥10%, <20%), and high- (>20%) risk. For the analysis, the intermediate and high risk groups were integrated and compared with the low risk group. CVD outcomes included coronary death, myocardial infarction, coronary insufficiency, angina, ischemic stroke, hemorrhagic stroke, transient ischemic attack, peripheral artery disease, and heart failure [10]. Initially, the Framingham risk score was developed to assess the risk of only coronary heart disease; however, in 2008, it was updated to include the above-mentioned conditions and has been used to predict the 10- and 30-year CVD risk of an individual.

3) Definition of variables

The following sociodemographic characteristics were considered possible confounders: age (continuous, years), sex (categorical, male or female), body mass index (BMI; continuous, kg/m2), marital status (categorical, married or unmarried), employment (categorical, employed or unemployed), household income (categorical, 1st, 2nd, 3rd, or 4th quartile), alcohol use (categorical, drinker or non-drinker), comorbidities (categorical, yes or no), and family history of CVD (categorical, yes or no).

Blood tests and blood pressure measurements were performed. Blood test was performed after fasting for at least 8 hours from dinner before the day of the test. Blood pressure was measured 3 times every 5 minutes, and the average of the second and third blood pressure measurements was used.

BMI was calculated by dividing weight (kg) by height squared (m2). For the evaluation of employment status, seven occupational groups were assessed, namely, managers, office workers, service and sales workers, agricultural and fishery workers, technicians, simple labor workers, and unemployed participants (housewives and students were classified as unemployed). Household income represents the monthly average income per household and was categorized into quartiles. Participants consuming even a few cigarettes or a little alcohol were classified as current smokers or drinkers, respectively. Comorbidities were defined as a morbid state of hypertension, diabetes mellitus, or dyslipidemia. Family history of CVD included ischemic heart disease and cerebral infarction in the father, mother, or siblings.

4) Statistical analysis

The complex sample analysis was conducted for weighting assessment of the KNHANES data. To compare sociodemographic characteristics by sedentary lifestyle groups, we conducted one-way analyses of variance for continuous variables and chi-square tests for categorical variables. The results are presented as mean±standard error or number.

To predict the 10-year risk of CVD, the Framingham Heart Study 10-year CVD risk calculator was used. To calculate the odds ratio (OR) for intermediate to high 10-year CVD risk, adjusted logistic regression analyses were performed, taking into consideration age, sex, BMI, marital status, employment, household income, alcohol use, family history of CVD, and comorbidity (history of hypertension, diabetes, and dyslipidemia). P<0.05 was considered statistically significant. Data were analyzed using Stata MP ver. 15.0 for Windows (Stata Corp., College Station, TX, USA).

RESULTS

1. Baseline Characteristics of Study Participants

Table 1 shows characteristics of the participants in this study. Participants were divided into six sedentary lifestyle groups according their physical activity and sedentary time. This study included a total of 14,551 participants (6,323 men and 8,228 women), with 8,053 in the moderate/high physical activity group and 6,498 in the low physical activity group. The average age of participants was 51.10±12.14 years. In both the moderate/high and low physical activity groups, the average age of the <6 h/d sedentary time group was 3 years higher than that of the ≥9 h/d sedentary time group (moderate/high, 52.04±11.62 years versus 48.98±12.20 years; low, 52.82±11.73 years versus 49.73±12.54 years; P<0.001). The proportion of women was relatively high in the low physical activity group (groups 4–6). The average BMI was 24.03 kg/m2. The mean sedentary time of participants was 7.49 h/d. The average estimated 10-year CVD risk was 9.58%, and the risk was ≥10% in 33.2% of the total participants. The calculated probability of intermediate to high risk (10-year risk ≥10%) in each of the six groups was 34.2% (group 1), 32.9% (group 2), 30.2% (group 3), 35.8% (group 4), 35.0% (group 5), and 31.8% (group 6) (Table 1).

Table 1.

Sociodemographic characteristics of study participants according to sedentary lifestyle groups

Characteristic	Total	Moderate/high physical activity (n=8,053)			Low physical activity (n=6,498)			P-value[*]
		Group 1: sedentary time <6 h	Group 2: sedentary time 6–<9 h	Group 3: sedentary time ≥9 h	Group 4: sedentary time <6 h	Group 5: sedentary time 6–<9 h	Group 6: sedentary time ≥9 h
Total		2,964	2,332	2,757	2,156	1,762	2,580
Age (y)	51.10±12.14	52.04±11.62	51.37±12.01	48.98±12.20	52.82±11.73	52.34±12.30	49.73±12.54	<0.001
30–44	5,007 (34.4)	901 (30.4)	791 (33.9)	1,144 (41.5)	614 (28.5)	543 (30.8)	1,014 (39.3)	<0.001
45–59	5,437 (37.4)	1,179 (39.8)	860 (36.9)	994 (36.0)	849 (39.4)	635 (36.0)	920 (35.7)
60–74	4,107 (28.2)	884 (29.8)	681 (29.2)	619 (22.5)	693 (32.1)	584 (33.2)	646 (25.0)
Sex
Male	6,323 (43.5)	1,298 (43.8)	1,048 (44.9)	1,378 (50.0)	834 (38.7)	666 (27.8)	1,099 (42.6)	<0.001
Female	8,228 (56.5)	1,666 (56.2)	1,284 (55.1)	1,379 (50.0)	1,322 (61.3)	1,096 (62.2)	1,481 (57.4)
Body mass index (kg/m2)	24.03±3.40	23.95±3.24	24.11±3.31	24.21±3.41	23.87±3.34	23.84±3.49	24.13±3.62	<0.001
<18.5.0	440 (3.0)	77 (2.6)	66 (2.8)	69 (2.5)	70 (3.2)	75 (4.3)	83 (3.2)	<0.001
18.5.0–24.9	8,978 (61.7)	1,866 (63.0)	1,435 (61.6)	1,657 (60.2)	1,394 (64.7)	1,086 (61.7)	1,540 (59.7)
≥25.0	5,126 (35.2)	1,021 (34.4)	830 (35.6)	1,028 (37.3)	692 (32.1)	600 (34.1)	955 (37.0)
Marital status
Married	13,487 (92.7)	2,802 (94.5)	2,159 (92.6)	2,451 (88.9)	2,064 (95.7)	1,645 (93.4)	2,366 (91.7)	<0.001
Unmarried	1,064 (7.3)	162 (5.5)	173 (7.4)	306 (11.1)	92 (4.3)	117 (6.6)	214 (8.3)
Employment
Employed	9,749 (67.2)	1,929 (65.3)	1,470 (63.3)	1,881 (68.4)	1,554 (72.2)	1,156 (65.8)	1,759 (68.3)	<0.001
Unemployed	4,767 (32.8)	1,026 (34.7)	853 (36.7)	870 (31.6)	598 (27.8)	602 (34.2)	818 (31.7)
Household income[†]
Quartile 1	1,965 (13.5)	373 (12.6)	279 (12.0)	357 (9.3)	371 (17.2)	302 (17.2)	383 (14.9)	<0.001
Quartile 2	3,624 (25.0)	783 (26.5)	567 (24.4)	518 (18.8)	663 (30.8)	499 (28.3)	594 (23.1)
Quartile 3	4,339 (29.9)	927 (31.4)	711 (30.6)	823 (29.9)	639 (29.7)	501 (28.5)	738 (28.7)
Quartile 4	4,589 (31.6)	868 (29.4)	769 (33.1)	1,154 (41.9)	481 (22.3)	458 (26.0)	859 (33.4)
Smoking
Smoker	2,833 (19.5)	540 (18.2)	409 (17.5)	540 (19.6)	422 (19.6)	345 (19.6)	577 (22.4)	<0.001
Non-smoker	11,718 (80.5)	2,424 (81.8)	1,923 (82.5)	2,217 (80.4)	1,734 (80.4)	1,417 (80.4)	2,003 (77.6)
Sedentary time	7.49±3.51	3.88±1.10	7.03±0.87	11.19±1.92	3.78±1.16	7.08±1.16	11.48±2.09	<0.001
Alcohol use
Drinker	8,172 (56.2)	1,690 (57.0)	1,324 (56.8)	1,682 (61.0)	1,133 (52.5)	901 (51.1)	1,442 (55.9)	<0.001
Non-drinker	6,379 (43.8)	1,274 (43.0)	1,008 (43.2)	1,075 (39.0)	1,023 (47.5)	861 (48.9)	1,138 (44.1)
Physical activity (METs·min/wk)
Low (<600)	6,498 (44.7)	0	0	0	2,156 (100.0)	1,762 (100.0)	2,580 (100.0)	<0.001
Moderate (600–<3,000)	6,328 (43.5)	2,115 (71.4)	1,889 (81.0)	2,324 (84.3)	0	0	0
High (≥3,000)	1,725 (11.8)	849 (28.6)	443 (19.0)	433 (15.7)	0	0	0
Comorbidities[‡]
Yes	4,061 (27.9)	787 (26.5)	698 (29.9)	702 (25.5)	634 (29.4)	549 (31.2)	691 (26.8)	<0.001
No	10,490 (72.1)	2,177 (73.5)	1,634 (70.1)	2,055 (74.5)	1,522 (70.6)	1,213 (68.8)	1,889 (73.2)
Family history of CVD[§]
Yes	2,878 (19.8)	601 (20.3)	484 (20.8)	555 (20.1)	388 (18.0)	340 (19.3)	510 (19.8)	0.248
No	11,673 (80.2)	2,363 (79.7)	1,848 (79.3)	2,202 (79.9)	1,768 (82.0)	1,422 (80.7)	2,070 (80.2)
10-Year CVD risk	9.58±10.41	9.65±10.02	9.62±10.41	8.85±9.98	10.08±10.42	10.00±10.56	9.54±11.09	<0.001
<10%	9,728 (66.8)	1,950 (65.8)	1,566 (67.1)	1,923 (69.8)	1,384 (64.2)	1,145 (65.0)	1,760 (68.2)	<0.001
≥10%, <20%	2,936 (20.2)	635 (21.4)	445 (19.1)	533 (19.3)	478 (22.2)	375 (21.3)	470 (18.2)
>20%	1,887 (13.0)	379 (12.8)	321 (13.8)	301 (10.9)	294 (13.6)	242 (13.7)	350 (13.6)

Values are presented as mean±standard error or number (%). The sum of each subgroup is not the same because of missing data. Statistically significant results are marked in bold.

MET, metabolic equivalent of task; CVD, cardiovascular disease.

One-way analyses of variance for continuous variables and chi-square tests for categorical variables.

Quartiles were generated using the monthly average household equivalent income in the same sex and age groups.

Participants who were ever diagnosed with hypertension or diabetes or dyslipidemia.

Ischemic heart disease or stroke history in parents and siblings.

2. Joint Associations of Sedentary Time and Physical Activity with the 10-Year Cardiovascular Disease Risk

Adjusted ORs for intermediate to high 10-year CVD risk (10-year risk ≥10%) are presented in Table 2. Compared with group 1 (reference group), which is the moderate/high physical activity group and has a sedentary time of <6 h/d, after adjusting for age and sex (model 1), the OR (95% confidence interval) was 1.001 (0.810–1.238) for group 2, 1.025 (0.843–1.247) for group 3, 1.195 (0.952–1.501) for group 4, 1.277 (1.018–1.602) for group 5, and 1.372 (1.110–1.698) for group 6. There was no significant association between sedentary time and increased 10-year CVD risk in the moderate/high physical activity groups (groups 1–3). In the low physical activity groups, only groups 5 (P<0.05) and 6 (P<0.01) showed statistically significant results (Table 2).

Table 2.

Odds ratio for intermediate to high 10-year risk of cardiovascular disease (10-year risk ≥10%) according to sedentary lifestyle groups

Model	Moderate/high physical activity					Low physical activity
	Group 1: sedentary time <6 h	Group 2: sedentary time 6–<9 h		Group 3: sedentary time ≥9 h		Group 4: sedentary time <6 h		Group 5: sedentary time 6–<9 h		Group 6: sedentary time ≥9 h
	OR (95% CI)	OR (95% CI)	P-value[*]	OR (95% CI)	P-value[*]	OR (95% CI)	P-value[*]	OR (95% CI)	P-value[*]	OR (95% CI)	P-value[*]
Model 1	1.00	1.001 (0.810–1.238)	0.991	1.025 (0.843–1.247)	0.801	1.195 (0.952–1.501)	0.125	1.277 (1.018–1.602)	0.034	1.372 (1.110–1.698)	0.004
Model 2	1.00	0.954 (0.769–1.184)	0.672	0.960 (0.785–1.173)	0.688	1.216 (0.960–1.539)	0.104	1.245 (0.987–1.570)	0.064	1.310 (1.054–1.628)	0.015
Model 3	1.00	0.941 (0.752–1.178)	0.597	0.957 (0.778–1.178)	0.682	1.170 (0.918–1.491)	0.204	1.225 (0.964–1.557)	0.097	1.293 (1.035–1.615)	0.024

Values are presented as OR (95% CI). Statistically significant results are marked in bold. Model 1: adjusted for age and sex; model 2: adjusted for age, sex, and body mass index; and model 3: adjusted for age, sex, body mass index, marital status, employment, household income, alcohol use, family history of cardiovascular disease, and comorbidity.

OR, odds ratio; CI, confidence interval.

Obtained from the chi-square test (statistically significant at P<0.05).

After adjustments for age, sex, BMI, marital status, employment, household income, alcohol use, family history of CVD, and comorbidity, there was no significant association between sedentary time and increased 10-year CVD risk within the moderate/high physical activity groups (groups 1–3). In the low physical activity groups, the OR was 1.170 (0.918–1.491) for group 4, 1.225 (0.964–1.557) for group 5, and 1.293 (1.035–1.615) for group 6. Among participants in the low physical activity group, the OR was the highest in the group with sedentary time >9 h/d (group 6, P<0.05) (Table 2, Figure 1).

Figure. 1.

Joint associations of sedentary time, PA groups, and intermediate to high 10-year cardiovascular disease risk (10-year risk ≥10%). Odds ratio of the low PA group with >9 h/d sedentary time is 1.29±0.15, which is a statistically significant result (P<0.05). PA, physical activity; CI, confidence interval.

In models 1–3, a sedentary time of >9 h/d was associated with increased 10-year CVD risk (10-year risk ≥10%) in the low physical activity groups; however, low sedentary time (<6 h/d) was not associated with increased 10-year CVD risk in the low physical activity groups.

DISCUSSION

In this cross-sectional study, low physical activity and high sedentary time were positively associated with increased 10-year CVD risk (10-year risk ≥10%). Furthermore, especially in the low physical activity groups, if sedentary time was <6 h/d, there was no significant association with increased 10-year CVD risk in Korean adults, calculated using the Framingham Heart Study 10-year CVD risk calculator.

Previously, several studies have suggested that the higher the sedentary time, the higher the CVD risk [2,20-24]. Furthermore, recent studies have shown that the relationship between prolonged sedentary time and increased CVD risk is irrelevant to the physical activity level [2,5-9]. On the other hand, several studies have shown that the association between prolonged sedentary time and increased CVD mortality may become attenuated as the physical activity level increases [25].

Based on the existing WHO and Korea Health and Welfare Ministry standards, the recommended standard for physical activity in adults is moderate-intensity exercise for >150 minutes per week or >1 hour 15 minutes per week for vigorous-intensity exercise. When 4.0 METs are applied to moderate-intensity exercise and 8.0 METs are applied to vigorous-intensity exercise, the recommended amount of exercise is 600 METs∙min/wk [26]. It can be expected that the probability of a significant increase of 10-year CVD risk would not be higher even if the sedentary time increases, when physical activity is maintained at >600 METs∙min/wk.

Additionally, keeping the sedentary time <6 h/d was not associated with an increased 10-year CVD risk of >10%, even if physical activity was <600 METs∙min/wk. On the basis of these results, it would be beneficial to keep the sedentary time <6 h/d if physical activity is below the recommended amount.

The present study has many strengths. To the best of our knowledge, this is the first study to evaluate the relationship between sedentary time, physical activity, and 10-year CVD risk using a large representative sample of Korean adults. In addition, we adjusted for various sociodemographic and CVD-related factors. Further, whereas previous studies included individuals with preexisting conditions, we excluded patients who were diagnosed with cancer, stroke, angina, and myocardial infarction.

However, there are also several limitations to this study. First, the surrogate marker for increased CVD risk outcome is based on the Framingham risk score. The Framingham risk score has been known to overestimate the risk in the Asian-Pacific population [27,28]. Although the tool suggested by the American College of Cardiology (ACC)/American Heart Association (AHA), the Pooled Cohort risk assessment equation, shows better predictability, this is also susceptible to overestimation when applied to the Asian population [29]. Meanwhile, the Korean risk prediction model, which was developed based on the ACC/AHA prediction model, is considered to show more predictability for the Korean population [30]; however, there are not enough tools available to clinicians and patients. The Framingham study-related model, which was also used in this study, has the advantage of having a high clinical utilization. However, its clinical use has been greatly reduced owing to the development of a new predictive model and numerous limitations to consider at present. Second, this study could not identify the minimum cutoff value of sedentary time to avoid increasing the 10-year CVD risk in each physical activity group, as sedentary time in this study was classified using an arbitrarily defined criterion. The third limitation is that this was a cross-sectional study. Thus, it is only possible to present a link to the results, as we could not intervene in the data collection process. There were also limitations in inferring causal relationships between data. The fourth limitation is that this study was based on self-reported results collected through surveys of sedentary time and physical activity. Therefore, there is a possibility of participant bias, resulting in a lack of objectivity and standardization and possibly reducing the reliability owing to recall errors.

In summary, our analysis of sedentary time, physical activity, and increased 10-year CVD risk found that in low physical activity groups, low sedentary time (<6 h/d) was not associated with increased 10-year CVD risk. From this point of view, reduction of sedentary time can be an important strategy for preventing the increase of CVD risk in populations with low physical activity, especially in those with less than the recommended amount of exercise or those who do not exercise sufficiently because of occupational characteristics. Thus, further longitudinal cohort studies are required and providing education on the importance of reducing sedentary time is needed.