Bruna Regis de Paiva1,2, Marta Esgalhado3, Natália Alvarenga Borges3, Julie Ann Kemp4, Gutemberg Alves5, Paulo Emílio Corrêa Leite6, Renata Macedo3, Ludmila F M F Cardozo3, Jessyca Sousa de Brito3, Denise Mafra4,3. 1. Graduate Program in Medical Sciences, Fluminense Federal University, Niterói, RJ, Brazil. bruna.regis.paiva@gmail.com. 2. Hospital Universitário Antônio Pedro, Rua Marquês do Paraná nº 303, 4º andar, Niterói, Rio de Janeiro, Brazil. bruna.regis.paiva@gmail.com. 3. Graduate Program in Cardiovascular Sciences, Fluminense Federal University, Niterói, RJ, Brazil. 4. Graduate Program in Medical Sciences, Fluminense Federal University, Niterói, RJ, Brazil. 5. Clinical Research Unit, Antônio Pedro Hospital, Fluminense Federal University, Niterói, RJ, Brazil. 6. Laboratory of Bioengineering and in Vitro Toxicology, Directory of Metrology Applied to Life Science-Dimav, National Institute of Metrology Quality and Technology-INMETRO, Duque de Caxias, RJ, Brazil.
Abstract
PURPOSE: In chronic kidney disease (CKD) patients, dysbiosis is associated with inflammation and cardiovascular risk, so many nutritional strategies are being studied to reduce these complications. Resistant starch (RS) can be considered a prebiotic that promotes many benefits, including modulation of gut microbiota which is linked to immune-modulatory effects. The aim of this study was to evaluate the effects of RS supplementation on proinflammatory cytokines in CKD patients on hemodialysis (HD). METHODS: A double-blind, placebo-controlled, randomized trial was conducted with sixteen HD patients (55.3 ± 10.05 years, body mass index (BMI) 25.9 ± 5.42 kg/m2, 56% men, time on dialysis 38.9 ± 29.23 months). They were allocated to the RS group (16 g RS/day) or placebo group (manioc flour). The serum concentration of ten cytokines and growth factors was detected through a multiparametric immunoassay based on XMap-labeled magnetic microbeads (Luminex Corp, USA) before and after 4 weeks with RS supplementation. RESULTS: After RS supplementation, there was a reduction of Regulated upon Activation, Normal T-Cell Expressed and Secreted (p < 0.001), platelet-derived growth factor (two B subunits) (p = 0.014) and interferon-inducible protein 10 (IP-10) (p = 0.027). The other parameters did not change significantly. CONCLUSION: This preliminary result indicates that RS may contribute to a desirable profile of inflammatory markers in CKD patients.
RCT Entities:
PURPOSE: In chronic kidney disease (CKD) patients, dysbiosis is associated with inflammation and cardiovascular risk, so many nutritional strategies are being studied to reduce these complications. Resistant starch (RS) can be considered a prebiotic that promotes many benefits, including modulation of gut microbiota which is linked to immune-modulatory effects. The aim of this study was to evaluate the effects of RS supplementation on proinflammatory cytokines in CKDpatients on hemodialysis (HD). METHODS: A double-blind, placebo-controlled, randomized trial was conducted with sixteen HD patients (55.3 ± 10.05 years, body mass index (BMI) 25.9 ± 5.42 kg/m2, 56% men, time on dialysis 38.9 ± 29.23 months). They were allocated to the RS group (16 g RS/day) or placebo group (manioc flour). The serum concentration of ten cytokines and growth factors was detected through a multiparametric immunoassay based on XMap-labeled magnetic microbeads (Luminex Corp, USA) before and after 4 weeks with RS supplementation. RESULTS: After RS supplementation, there was a reduction of Regulated upon Activation, Normal T-Cell Expressed and Secreted (p < 0.001), platelet-derived growth factor (two B subunits) (p = 0.014) and interferon-inducible protein 10 (IP-10) (p = 0.027). The other parameters did not change significantly. CONCLUSION: This preliminary result indicates that RS may contribute to a desirable profile of inflammatory markers in CKDpatients.
Authors: Tammy L Sirich; Natalie S Plummer; Christopher D Gardner; Thomas H Hostetter; Timothy W Meyer Journal: Clin J Am Soc Nephrol Date: 2014-08-21 Impact factor: 8.237
Authors: Dorothy A Kieffer; Brian D Piccolo; Nosratola D Vaziri; Shuman Liu; Wei L Lau; Mahyar Khazaeli; Sohrab Nazertehrani; Mary E Moore; Maria L Marco; Roy J Martin; Sean H Adams Journal: Am J Physiol Renal Physiol Date: 2016-02-03
Authors: Livia Alvarenga; Ludmila F M F Cardozo; Beatriz O Da Cruz; Bruna R Paiva; Denis Fouque; Denise Mafra Journal: Int Urol Nephrol Date: 2022-03-26 Impact factor: 2.266