| Literature DB >> 32006158 |
Wajih Bukhari1, Laura Clarke1,2, Cullen O'Gorman1,2, Elham Khalilidehkordi1,3, Simon Arnett1,3, Kerri M Prain4, Mark Woodhall5, Roger Silvestrini6, Christine S Bundell7, Sudarshini Ramanathan8, David Abernethy9, Sandeep Bhuta1, Stefan Blum10, Mike Boggild11, Karyn Boundy12, Bruce J Brew13, Wallace Brownlee14, Helmut Butzkueven15, William M Carroll16, Celia Chen17, Alan Coulthard18, Russell C Dale19, Chandi Das20, Keith Dear21, Marzena J Fabis-Pedrini22, David Fulcher23, David Gillis18, Simon Hawke23, Robert Heard19, Andrew P D Henderson24, Saman Heshmat1, Suzanne Hodgkinson25, Sofia Jimenez-Sanchez1, Trevor J Kilpatrick26, John King27, Chris Kneebone11, Andrew J Kornberg28, Jeannette Lechner-Scott29, Ming-Wei Lin23, Christopher Lynch30, Richard A L Macdonnell31, Deborah F Mason32, Pamela A McCombe33, Jennifer Pereira30, John D Pollard23, Stephen W Reddel34, Cameron Shaw35, Judith Spies23, James Stankovich36, Ian Sutton37, Steve Vucic19, Michael Walsh9, Richard C Wong18, Eppie M Yiu28, Michael H Barnett34, Allan G Kermode16, Mark P Marriott15, John Parratt23, Mark Slee17, Bruce V Taylor35, Ernest Willoughby14, Robert J Wilson2, Fabienne Brilot7, Angela Vincent4, Patrick Waters4, Simon A Broadley38,39.
Abstract
Neuromyelitis optica spectrum disorders (NMOSD) are an inflammation of the central nervous system associated with autoantibodies to aquaporin-4. We have undertaken a clinic-based survey of NMOSD in the Australia and New Zealand populations with the aim of characterising the clinical features and establishing the value of recently revised diagnostic criteria. Cases of possible NMOSD and age and sex-matched controls with multiple sclerosis (MS) were referred from centres across Australia and New Zealand. Cases were classified as NMOSD if they met the 2015 IPND criteria and remained as suspected NMOSD if they did not. Clinical and paraclinical data were compared across the three groups. NMOSD was confirmed in 75 cases and 89 had suspected NMOSD. There were 101 controls with MS. Age at onset, relapse rates and EDSS scores were significantly higher in NMOSD than in MS. Lesions and symptoms referable to the optic nerve were more common in NMOSD whereas brainstem, cerebellar and cerebral lesions were more common in MS. Longitudinally extensive spinal cord lesions were seen in 48/71 (68%) of cases with NMOSD. Elevations of CSF, white cell count and protein were more common in NMOSD. We have confirmed a clinical pattern of NMOSD that has been seen in several geographical regions. We have demonstrated the clinical utility of the current diagnostic criteria. Distinct patterns of disease are evident in NMOSD and MS, but there remains a large number of patients with NMOSD-like features who do not meet the current diagnostic criteria for NMOSD and remain a diagnostic challenge.Entities:
Keywords: Aquaporin; Autoimmune disease; Clinical features; Multiple sclerosis; Neuromyelitis optica
Year: 2020 PMID： 32006158 DOI： 10.1007/s00415-020-09716-4
Source DB: PubMed Journal: J Neurol ISSN： 0340-5354 Impact factor: 4.849