Hideki Houzen1, Kimito Kondo1, Masaaki Niino2, Kazuhiro Horiuchi1, Toshiyuki Takahashi1, Ichiro Nakashima1, Keiko Tanaka1. 1. From the Department of Neurology (H.H., K.H.), Obihiro Kosei General Hospital, Obihiro; Department of Neurology (K.K.), Hokuto Hospital, Obihiro; Department of Clinical Research (M.N.), Hokkaido Medical Center, Sapporo; Department of Neurology (T.T., I.N.), Tohoku University, Sendai; Department of Neurology (T.T.), Yonezawa National Hospital, Yonezawa; Department of Neurology (I.N.), Tohoku Medical and Pharmaceutical University, Sendai; and Department of Cellular Neurobiology (K.T.), Brain Research Institute, Niigata University, Niigata, Japan. 2. From the Department of Neurology (H.H., K.H.), Obihiro Kosei General Hospital, Obihiro; Department of Neurology (K.K.), Hokuto Hospital, Obihiro; Department of Clinical Research (M.N.), Hokkaido Medical Center, Sapporo; Department of Neurology (T.T., I.N.), Tohoku University, Sendai; Department of Neurology (T.T.), Yonezawa National Hospital, Yonezawa; Department of Neurology (I.N.), Tohoku Medical and Pharmaceutical University, Sendai; and Department of Cellular Neurobiology (K.T.), Brain Research Institute, Niigata University, Niigata, Japan. niino@hok-mc.hosp.go.jp.
Abstract
OBJECTIVE: To clarify the prevalence and clinical characteristics of neuromyelitis optica spectrum disorders (NMOSD) in Japan and compare them with those in other ethnic populations. METHODS: Data processing sheets were sent to all related institutions in northern Japan and were collected from April to May 2016. Prevalence was determined on March 31, 2016, using the 2015 International Panel for NMO Diagnosis criteria. RESULTS: The crude prevalence was 4.1/100,000 (95% confidence interval 2.2-6.9) for NMOSD in northern Japan, with a significantly higher number of female than male patients (female: male 12:2). The positivity for anti-aquaporin-4 antibody was 78.6%, and the mean age at onset was 45.2 years. All patients were subjected to preventive therapy in the form of treatment with steroids or immunosuppressive agents. CONCLUSIONS: Our results showed that the prevalence of NMOSD in the Japanese population is similar to that in Caucasians.
OBJECTIVE: To clarify the prevalence and clinical characteristics of neuromyelitis optica spectrum disorders (NMOSD) in Japan and compare them with those in other ethnic populations. METHODS: Data processing sheets were sent to all related institutions in northern Japan and were collected from April to May 2016. Prevalence was determined on March 31, 2016, using the 2015 International Panel for NMO Diagnosis criteria. RESULTS: The crude prevalence was 4.1/100,000 (95% confidence interval 2.2-6.9) for NMOSD in northern Japan, with a significantly higher number of female than male patients (female: male 12:2). The positivity for anti-aquaporin-4 antibody was 78.6%, and the mean age at onset was 45.2 years. All patients were subjected to preventive therapy in the form of treatment with steroids or immunosuppressive agents. CONCLUSIONS: Our results showed that the prevalence of NMOSD in the Japanese population is similar to that in Caucasians.
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