Daniele Roberto Giacobbe1,2, Alberto Enrico Maraolo3, Vittorio Simeon4, Federica Magnè1,2, Maria Caterina Pace5, Ivan Gentile3, Paolo Chiodini4, Claudio Viscoli1,2, Maurizio Sanguinetti6, Malgorzata Mikulska1,2, Marco Fiore5, Matteo Bassetti1,2. 1. Clinica Malattie Infettive, Ospedale Policlinico San Martino - IRCCS, Genoa, Italy. 2. Department of Health Sciences, University of Genoa, Genoa, Italy. 3. Section of Infectious Diseases, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy. 4. Department of Public, Clinical and Preventive Medicine, Medical Statistics Unit, University of Campania Luigi Vanvitelli, Naples, Italy. 5. Department of Women, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy. 6. Institute of Microbiology, Fondazione Policlinico Universitario A. Gemelli IRCCS - Università Cattolica del Sacro Cuore, Rome, Italy.
Abstract
BACKGROUND: Candidaemia remains associated with high mortality and increased costs worldwide. OBJECTIVE: To assess the changes over time in the relative prevalence of non-albicans candidaemia (NAC). METHODS: A systematic review, meta-analysis and meta-regression were performed. Observational studies investigating the epidemiology of consecutive, non-selected, candidaemia episodes were included. Two separated analyses were conducted: (a) whole hospital analysis and (b) intensive care unit (ICU) analysis. RESULTS: Starting from an initial total of 7726 records, 220 studies fulfilled inclusion criteria. The pooled prevalence of NAC in whole hospital analysis was 49.5% (95% confidence intervals [CI] 48.0-51.1, I2 93.1%), while the pooled prevalence in ICU analysis was 50.6% (95% CI 46.6-54.6; I2 86.7%). In meta-regression, a progressive increase in NAC prevalence was observed in whole hospital analysis, although it explained only a small portion of between-study variance (estimated yearly prevalence change +0.3%, 95% CI from +0.1% to +0.5%, P = .003; adjusted R2 3.42%) and was observed only in some continents in subgroup analyses. No relevant changes over time were observed in NAC prevalence for ICU studies. CONCLUSIONS: We registered an increasing trend in the relative prevalence of NAC, which, nonetheless, seems to be limited to some continents and to contribute only minimally to explain the observed differences in NAC prevalence across studies.
BACKGROUND: Candidaemia remains associated with high mortality and increased costs worldwide. OBJECTIVE: To assess the changes over time in the relative prevalence of non-albicans candidaemia (NAC). METHODS: A systematic review, meta-analysis and meta-regression were performed. Observational studies investigating the epidemiology of consecutive, non-selected, candidaemia episodes were included. Two separated analyses were conducted: (a) whole hospital analysis and (b) intensive care unit (ICU) analysis. RESULTS: Starting from an initial total of 7726 records, 220 studies fulfilled inclusion criteria. The pooled prevalence of NAC in whole hospital analysis was 49.5% (95% confidence intervals [CI] 48.0-51.1, I2 93.1%), while the pooled prevalence in ICU analysis was 50.6% (95% CI 46.6-54.6; I2 86.7%). In meta-regression, a progressive increase in NAC prevalence was observed in whole hospital analysis, although it explained only a small portion of between-study variance (estimated yearly prevalence change +0.3%, 95% CI from +0.1% to +0.5%, P = .003; adjusted R2 3.42%) and was observed only in some continents in subgroup analyses. No relevant changes over time were observed in NAC prevalence for ICU studies. CONCLUSIONS: We registered an increasing trend in the relative prevalence of NAC, which, nonetheless, seems to be limited to some continents and to contribute only minimally to explain the observed differences in NAC prevalence across studies.
Authors: Aline El Zakhem; Rachid Istambouli; Maria Alkozah; Amal Gharamti; Mohamad Ali Tfaily; Jean-Francois Jabbour; George F Araj; Hani Tamim; Souha S Kanj Journal: Pathogens Date: 2021-01-19
Authors: Radim Dobiáš; Marcela Káňová; Naděžda Petejová; Štefan Kis Pisti; Robert Bocek; Eva Krejčí; Helena Stružková; Michaela Cachová; Hana Tomášková; Petr Hamal; Vladimír Havlíček; Milan Raška Journal: J Fungi (Basel) Date: 2022-03-17