| Literature DB >> 31993499 |
Jesse D Gelles1,2, Jerry Edward Chipuk1,2,3,4,5.
Abstract
Quantifying cytostatic and cytotoxic outcomes of cells responding to perturbagens is an essential component of mechanism-based studies and pharmacological screening approaches. We recently described an easy and versatile method for single-cell and population-level analyses using real-time kinetic labeling (SPARKL). This technology enables zero-handling, non-disruptive protocols for integrating proliferation profiles with cell death mechanisms, along with advanced mathematics for robust analyses.Entities:
Keywords: Apoptosis; SPARKL; cell death; ferroptosis; high-throughput; kinetics; live-cell imaging; necroptosis; proliferation; real-time analysis
Year: 2019 PMID: 31993499 PMCID: PMC6961694 DOI: 10.1080/23723556.2019.1685841
Source DB: PubMed Journal: Mol Cell Oncol ISSN: 2372-3556