Tulasi Nayak 1 , Keerthi R 1 Show Affiliations »
Abstract
BACKGROUND: A routine mandibular fracture matures in about 12 weeks and hence hinders normal function significantly. Alternatives are being researched to hasten the healing and allow early function. This prospective study aimed to assess the osteogenic potential of the drug Cissus quadrangularis (CQ) on the mandibular fracture healing. DESIGN: Prospective randomized study. RESULTS: The study between the groups revealed a statistically significant increase in the alkaline phosphatase levels in CQ group in comparison with control group. The radiographic findings (increment in density and rate of change of density), clinical findings (mobility, swelling, reduction in pain) and other biochemical findings (serum calcium, serum phosphorous) did not differ statistically between the CQ and control groups. CONCLUSION: Based on the lack of a statistically significant improvement in almost all parameters except for the alkaline phosphatase levels, we believe that a larger sample size is required to ascertain the absolute value of CQ before adding it to the mandibular fracture regimen. © The Association of Oral and Maxillofacial Surgeons of India 2019.
BACKGROUND: A routine mandibular fracture matures in about 12 weeks and hence hinders normal function significantly. Alternatives are being researched to hasten the healing and allow early function. This prospective study aimed to assess the osteogenic potential of the drug Cissus quadrangularis (CQ) on the mandibular fracture healing. DESIGN: Prospective randomized study. RESULTS: The study between the groups revealed a statistically significant increase in the alkaline phosphatase levels in CQ group in comparison with control group. The radiographic findings (increment in density and rate of change of density), clinical findings (mobility, swelling, reduction in pain) and other biochemical findings (serum calcium, serum phosphorous) did not differ statistically between the CQ and control groups. CONCLUSION: Based on the lack of a statistically significant improvement in almost all parameters except for the alkaline phosphatase levels, we believe that a larger sample size is required to ascertain the absolute value of CQ before adding it to the mandibular fracture regimen. © The Association of Oral and Maxillofacial Surgeons of India 2019.
Entities: Chemical
Keywords:
Ayurveda; Cissus quadrangularis; Fracture healing; Mandibular fracture
Year: 2019
PMID： 31988572 PMCID： PMC6954941 DOI： 10.1007/s12663-019-01230-z
Source DB: PubMed Journal: J Maxillofac Oral Surg ISSN： 0972-8270