| Literature DB >> 31985056 |
Shima Jahani1,2, Elahe Nazeri1, Keivan Majidzadeh-A1, Mona Jahani3, Rezvan Esmaeili1.
Abstract
Circular RNAs (circRNAs) were recently discovered as a looped subset of competing endogenous RNAs, with an ability to regulate gene expression by microRNA sponging. There are several studies on their potential roles in cancer development, such as colorectal cancer and basal cell carcinoma. However, there is still a significant gap in the knowledge about circRNA functions in breast cancer (BC) progression. The current study systematically reviewed circRNA biogenesis and their potential roles as a novel biomarker in BC on published studies of the MEDLINE®/PubMed, Cochrane®, and Scopus® databases. The obtained results showed a general dysregulation of circRNAs expression in BC cells with a cell-type and stage-specific manner. The potential connection between circRNAs and BC cell proliferation, apoptosis, metastasis, and chemotherapy sensitivity and resistance were discussed.Entities:
Keywords: breast cancer; circular RNA; control of apoptosis; drug resistance; long noncoding RNA; noncoding RNA
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Year: 2020 PMID： 31985056 DOI： 10.1002/jcp.29558
Source DB: PubMed Journal: J Cell Physiol ISSN： 0021-9541 Impact factor: 6.384