| Literature DB >> 31980301 |
Dean Ho1, Stephen R Quake2, Edward R B McCabe3, Wee Joo Chng4, Edward K Chow5, Xianting Ding6, Bruce D Gelb7, Geoffrey S Ginsburg8, Jason Hassenstab9, Chih-Ming Ho10, William C Mobley11, Garry P Nolan12, Steven T Rosen13, Patrick Tan14, Yun Yen15, Ali Zarrinpar16.
Abstract
Individualizing patient treatment is a core objective of the medical field. Reaching this objective has been elusive owing to the complex set of factors contributing to both disease and health; many factors, from genes to proteins, remain unknown in their role in human physiology. Accurately diagnosing, monitoring, and treating disorders requires advances in biomarker discovery, the subsequent development of accurate signatures that correspond with dynamic disease states, as well as therapeutic interventions that can be continuously optimized and modulated for dose and drug selection. This work highlights key breakthroughs in the development of enabling technologies that further the goal of personalized and precision medicine, and remaining challenges that, when addressed, may forge unprecedented capabilities in realizing truly individualized patient care.Entities:
Keywords: artificial intelligence; clinical trials; diagnostics; personalized medicine; precision medicine; therapeutics
Mesh：
Substances：
Year: 2020 PMID： 31980301 PMCID： PMC7924935 DOI： 10.1016/j.tibtech.2019.12.021
Source DB: PubMed Journal: Trends Biotechnol ISSN： 0167-7799 Impact factor: 19.536