Charlotte Gayer-Anderson1, Hannah E Jongsma2,3, Marta Di Forti4, Diego Quattrone4, Eva Velthorst5,6,7, Lieuwe de Haan7, Jean-Paul Selten8,9, Andrei Szöke10,11,12, Pierre-Michel Llorca13, Andrea Tortelli14, Celso Arango15, Julio Bobes16, Miguel Bernardo17, Julio Sanjuán18, José Luis Santos19, Manuel Arrojo20, Mara Parellada15, Ilaria Tarricone21, Domenico Berardi21, Mirella Ruggeri22, Antonio Lasalvia22,23, Laura Ferraro24, Caterina La Cascia24, Daniele La Barbera24, Paulo Rossi Menezes25, Cristina Marta Del-Ben26, Bart P Rutten9, Jim van Os9,27,28, Peter B Jones3,29, Robin M Murray28, James B Kirkbride2, Craig Morgan30. 1. Department of Health Services and Population Research, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AF, England. 2. PsyLife Group, Division of Psychiatry, University College London, London, England. 3. Department of Psychiatry, University of Cambridge, Cambridge, England. 4. Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England. 5. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA. 6. Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, USA. 7. Early Psychosis Section, Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands. 8. Institute for Mental Health, GGZ Rivierduinen, Leiden, The Netherlands. 9. Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands. 10. Institut National de la Santé et de la Recherche Médicale, U955, Equipe 15 Neuro-Psychiatrie Translationnelle, Créteil, France. 11. AP-HP, Pôle de Psychiatrie des Hôpitaux Universitaires Henri Mondor, Créteil, France. 12. Fondation FondaMental, Créteil, France. 13. EA 7280 Npsydo, Université Clermont Auvergne, Clermont-Ferrand, France. 14. Establissement Public de Santé, Maison Blanche, Paris, France. 15. Department of Child and Adolescent Psychiatry, Hospital General Universitario Gregorio Marañón, School of Medicine, Universidad Complutense, ISGM, CIBERSAM, Madrid, Spain. 16. Department of Medicine, Psychiatry Area, School of Medicine, Universidad de Oviedo, Centro de Investigación Biomédica en Red de Salud Mental, Oviedo, Spain. 17. Barcelona Clinic Schizophrenia Unit, Hospital Clinic, Department of Medicine, Neuroscience Institute, University of Barcelona, Institut d'Investigacions Biomèdiques, August Pi I Sunyer, Centro de Investigación Biomédica en Red de Salud Mental, Barcelona, Spain. 18. Department of Psychiatry, School of Medicine, Universidad de Valencia, Centro de Investigación Biomédica en Red de Salud Mental, Valencia, Spain. 19. Department of Psychiatry, Hospital "Virgen de la Luz", Cuenca, Spain. 20. Department of Psychiatry, Psychiatric Genetic Group, Instituto de Investigación Sanitaria de Santiago de Compostela, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago, Spain. 21. Department of Biomedical and NeuroMotor Sciences, Psychiatry Unit, Alma Mater Studiorium Università di Bologna, Bologna, Italy. 22. Section of Psychiatry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy. 23. Section of Psychiatry, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy. 24. Department of Experimental Biomedicine and Clinical Neuroscience, Section of Psychiatry, University of Palermo, Palermo, Italy. 25. Department of Preventive Medicine, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. 26. Division of Psychiatry, Department of Neuroscience and Behaviour, Ribeirão Preto Medical School, Universidade de São Paulo, São Paulo, Brazil. 27. Department of Psychiatry, Brain Center Rudolf Magnus, Utrecht University Medical Centre, Utrecht, The Netherlands. 28. Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England. 29. CAMEO Early Intervention Service, Cambridgeshire and Peterborough National Health Service Foundation Trust, Cambridge, England. 30. Department of Health Services and Population Research, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AF, England. craig.morgan@kcl.ac.uk.
Abstract
PURPOSE: The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) study contains an unparalleled wealth of comprehensive data that allows for testing hypotheses about (1) variations in incidence within and between countries, including by urbanicity and minority ethnic groups; and (2) the role of multiple environmental and genetic risk factors, and their interactions, in the development of psychotic disorders. METHODS: Between 2010 and 2015, we identified 2774 incident cases of psychotic disorders during 12.9 million person-years at risk, across 17 sites in 6 countries (UK, The Netherlands, France, Spain, Italy, and Brazil). Of the 2774 incident cases, 1130 cases were assessed in detail and form the case sample for case-control analyses. Across all sites, 1497 controls were recruited and assessed. We collected data on an extensive range of exposures and outcomes, including demographic, clinical (e.g. premorbid adjustment), social (e.g. childhood and adult adversity, cannabis use, migration, discrimination), cognitive (e.g. IQ, facial affect processing, attributional biases), and biological (DNA via blood sample/cheek swab). We describe the methodology of the study and some descriptive results, including representativeness of the cohort. CONCLUSIONS: This resource constitutes the largest and most extensive incidence and case-control study of psychosis ever conducted.
PURPOSE: The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) study contains an unparalleled wealth of comprehensive data that allows for testing hypotheses about (1) variations in incidence within and between countries, including by urbanicity and minority ethnic groups; and (2) the role of multiple environmental and genetic risk factors, and their interactions, in the development of psychotic disorders. METHODS: Between 2010 and 2015, we identified 2774 incident cases of psychotic disorders during 12.9 million person-years at risk, across 17 sites in 6 countries (UK, The Netherlands, France, Spain, Italy, and Brazil). Of the 2774 incident cases, 1130 cases were assessed in detail and form the case sample for case-control analyses. Across all sites, 1497 controls were recruited and assessed. We collected data on an extensive range of exposures and outcomes, including demographic, clinical (e.g. premorbid adjustment), social (e.g. childhood and adult adversity, cannabis use, migration, discrimination), cognitive (e.g. IQ, facial affect processing, attributional biases), and biological (DNA via blood sample/cheek swab). We describe the methodology of the study and some descriptive results, including representativeness of the cohort. CONCLUSIONS: This resource constitutes the largest and most extensive incidence and case-control study of psychosis ever conducted.
Authors: Marc De Hert; Dan Cohen; Julio Bobes; Marcelo Cetkovich-Bakmas; Stefan Leucht; David M Ndetei; John W Newcomer; Richard Uwakwe; Itsuo Asai; Hans-Jurgen Möller; Shiv Gautam; Johan Detraux; Christoph U Correll Journal: World Psychiatry Date: 2011-06 Impact factor: 49.548
Authors: Michelle L Esterberg; Hanan D Trotman; Carrie Holtzman; Michael T Compton; Elaine F Walker Journal: Schizophr Res Date: 2010-03-19 Impact factor: 4.939
Authors: Jonna Perälä; Jaana Suvisaari; Samuli I Saarni; Kimmo Kuoppasalmi; Erkki Isometsä; Sami Pirkola; Timo Partonen; Annamari Tuulio-Henriksson; Jukka Hintikka; Tuula Kieseppä; Tommi Härkänen; Seppo Koskinen; Jouko Lönnqvist Journal: Arch Gen Psychiatry Date: 2007-01
Authors: Sarah M Hartz; Amy C Horton; Dana B Hancock; Timothy B Baker; Neil E Caporaso; Li-Shiun Chen; John E Hokanson; Sharon M Lutz; Mary L Marazita; Daniel W McNeil; Carlos N Pato; Michele T Pato; Eric O Johnson; Laura J Bierut Journal: Schizophr Res Date: 2017-03-08 Impact factor: 4.939
Authors: Lucía Colodro-Conde; Baptiste Couvy-Duchesne; John B Whitfield; Fabian Streit; Scott Gordon; Kathryn E Kemper; Loic Yengo; Zhili Zheng; Maciej Trzaskowski; Eveline L de Zeeuw; Michel G Nivard; Marjolijn Das; Rachel E Neale; Stuart MacGregor; Catherine M Olsen; David C Whiteman; Dorret I Boomsma; Jian Yang; Marcella Rietschel; John J McGrath; Sarah E Medland; Nicholas G Martin Journal: JAMA Psychiatry Date: 2018-09-01 Impact factor: 21.596
Authors: Filippo Varese; Feikje Smeets; Marjan Drukker; Ritsaert Lieverse; Tineke Lataster; Wolfgang Viechtbauer; John Read; Jim van Os; Richard P Bentall Journal: Schizophr Bull Date: 2012-03-29 Impact factor: 9.306
Authors: Marta Di Forti; Diego Quattrone; Tom P Freeman; Giada Tripoli; Charlotte Gayer-Anderson; Harriet Quigley; Victoria Rodriguez; Hannah E Jongsma; Laura Ferraro; Caterina La Cascia; Daniele La Barbera; Ilaria Tarricone; Domenico Berardi; Andrei Szöke; Celso Arango; Andrea Tortelli; Eva Velthorst; Miguel Bernardo; Cristina Marta Del-Ben; Paulo Rossi Menezes; Jean-Paul Selten; Peter B Jones; James B Kirkbride; Bart Pf Rutten; Lieuwe de Haan; Pak C Sham; Jim van Os; Cathryn M Lewis; Michael Lynskey; Craig Morgan; Robin M Murray Journal: Lancet Psychiatry Date: 2019-03-19 Impact factor: 77.056
Authors: Jim van Os; Bart P Rutten; Inez Myin-Germeys; Philippe Delespaul; Wolfgang Viechtbauer; Catherine van Zelst; Richard Bruggeman; Ulrich Reininghaus; Craig Morgan; Robin M Murray; Marta Di Forti; Philip McGuire; Lucia R Valmaggia; Matthew J Kempton; Charlotte Gayer-Anderson; Kathryn Hubbard; Stephanie Beards; Simona A Stilo; Adanna Onyejiaka; Francois Bourque; Gemma Modinos; Stefania Tognin; Maria Calem; Michael C O'Donovan; Michael J Owen; Peter Holmans; Nigel Williams; Nicholas Craddock; Alexander Richards; Isla Humphreys; Andreas Meyer-Lindenberg; F Markus Leweke; Heike Tost; Ceren Akdeniz; Cathrin Rohleder; J Malte Bumb; Emanuel Schwarz; Köksal Alptekin; Alp Üçok; Meram Can Saka; E Cem Atbaşoğlu; Sinan Gülöksüz; Guvem Gumus-Akay; Burçin Cihan; Hasan Karadağ; Haldan Soygür; Eylem Şahin Cankurtaran; Semra Ulusoy; Berna Akdede; Tolga Binbay; Ahmet Ayer; Handan Noyan; Gülşah Karadayı; Elçin Akturan; Halis Ulaş; Celso Arango; Mara Parellada; Miguel Bernardo; Julio Sanjuán; Julio Bobes; Manuel Arrojo; Jose Luis Santos; Pedro Cuadrado; José Juan Rodríguez Solano; Angel Carracedo; Enrique García Bernardo; Laura Roldán; Gonzalo López; Bibiana Cabrera; Sabrina Cruz; Eva Ma Díaz Mesa; María Pouso; Estela Jiménez; Teresa Sánchez; Marta Rapado; Emiliano González; Covadonga Martínez; Emilio Sánchez; Ma Soledad Olmeda; Lieuwe de Haan; Eva Velthorst; Mark van der Gaag; Jean-Paul Selten; Daniella van Dam; Elsje van der Ven; Floor van der Meer; Elles Messchaert; Tamar Kraan; Nadine Burger; Marion Leboyer; Andrei Szoke; Franck Schürhoff; Pierre-Michel Llorca; Stéphane Jamain; Andrea Tortelli; Flora Frijda; Jeanne Vilain; Anne-Marie Galliot; Grégoire Baudin; Aziz Ferchiou; Jean-Romain Richard; Ewa Bulzacka; Thomas Charpeaud; Anne-Marie Tronche; Marc De Hert; Ruud van Winkel; Jeroen Decoster; Catherine Derom; Evert Thiery; Nikos C Stefanis; Gabriele Sachs; Harald Aschauer; Iris Lasser; Bernadette Winklbaur; Monika Schlögelhofer; Anita Riecher-Rössler; Stefan Borgwardt; Anna Walter; Fabienne Harrisberger; Renata Smieskova; Charlotte Rapp; Sarah Ittig; Fabienne Soguel-dit-Piquard; Erich Studerus; Joachim Klosterkötter; Stephan Ruhrmann; Julia Paruch; Dominika Julkowski; Desiree Hilboll; Pak C Sham; Stacey S Cherny; Eric Y H Chen; Desmond D Campbell; Miaoxin Li; Carlos María Romeo-Casabona; Aitziber Emaldi Cirión; Asier Urruela Mora; Peter Jones; James Kirkbride; Mary Cannon; Dan Rujescu; Ilaria Tarricone; Domenico Berardi; Elena Bonora; Marco Seri; Thomas Marcacci; Luigi Chiri; Federico Chierzi; Viviana Storbini; Mauro Braca; Maria Gabriella Minenna; Ivonne Donegani; Angelo Fioritti; Daniele La Barbera; Caterina Erika La Cascia; Alice Mulè; Lucia Sideli; Rachele Sartorio; Laura Ferraro; Giada Tripoli; Fabio Seminerio; Anna Maria Marinaro; Patrick McGorry; Barnaby Nelson; G Paul Amminger; Christos Pantelis; Paulo R Menezes; Cristina M Del-Ben; Silvia H Gallo Tenan; Rosana Shuhama; Mirella Ruggeri; Sarah Tosato; Antonio Lasalvia; Chiara Bonetto; Elisa Ira; Merete Nordentoft; Marie-Odile Krebs; Neus Barrantes-Vidal; Paula Cristóbal; Thomas R Kwapil; Elisa Brietzke; Rodrigo A Bressan; Ary Gadelha; Nadja P Maric; Sanja Andric; Marina Mihaljevic; Tijana Mirjanic Journal: Schizophr Bull Date: 2014-05-24 Impact factor: 9.306
Authors: A Sariaslan; S Fazel; B M D'Onofrio; N Långström; H Larsson; S E Bergen; R Kuja-Halkola; P Lichtenstein Journal: Transl Psychiatry Date: 2016-05-03 Impact factor: 6.222
Authors: Diego Quattrone; Marta Di Forti; Charlotte Gayer-Anderson; Laura Ferraro; Hannah E Jongsma; Giada Tripoli; Caterina La Cascia; Daniele La Barbera; Ilaria Tarricone; Domenico Berardi; Andrei Szöke; Celso Arango; Antonio Lasalvia; Andrea Tortelli; Pierre-Michel Llorca; Lieuwe de Haan; Eva Velthorst; Julio Bobes; Miguel Bernardo; Julio Sanjuán; Jose Luis Santos; Manuel Arrojo; Cristina Marta Del-Ben; Paulo Rossi Menezes; Jean-Paul Selten; Peter B Jones; James B Kirkbride; Alexander L Richards; Michael C O'Donovan; Pak C Sham; Evangelos Vassos; Bart Pf Rutten; Jim van Os; Craig Morgan; Cathryn M Lewis; Robin M Murray; Ulrich Reininghaus Journal: Psychol Med Date: 2018-10-04 Impact factor: 7.723
Authors: Lucia Sideli; Adriano Schimmenti; Daniele La Barbera; Caterina La Cascia; Laura Ferraro; Monica Aas; Luis Alameda; Eva Velthorst; Helen L Fisher; Vincenzo Caretti; Giulia Trotta; Giada Tripoli; Diego Quattrone; Charlotte Gayer-Anderson; Fabio Seminerio; Crocettarachele Sartorio; Giovanna Marrazzo; Antonio Lasalvia; Sarah Tosato; Ilaria Tarricone; Domenico Berardi; Giuseppe D'Andrea; Celso Arango; Manuel Arrojo; Miguel Bernardo; Julio Bobes; Julio Sanjuán; Jose Luis Santos; Paulo Rossi Menezes; Cristina Marta Del-Ben; Hannah E Jongsma; Peter B Jones; James B Kirkbride; Pierre-Michel Llorca; Andrea Tortelli; Baptiste Pignon; Lieuwe de Haan; Jean-Paul Selten; Jim Van Os; Bart P Rutten; Marta Di Forti; Craig Morgan; Robin M Murray Journal: Schizophr Bull Date: 2022-05-07 Impact factor: 7.348
Authors: Baptiste Pignon; Mohamed Lajnef; James B Kirkbride; Hugo Peyre; Aziz Ferchiou; Jean-Romain Richard; Grégoire Baudin; Sarah Tosato; Hannah Jongsma; Lieuwe de Haan; Ilaria Tarricone; Miguel Bernardo; Eva Velthorst; Mauro Braca; Celso Arango; Manuel Arrojo; Julio Bobes; Cristina Marta Del-Ben; Marta Di Forti; Charlotte Gayer-Anderson; Peter B Jones; Caterina La Cascia; Antonio Lasalvia; Paulo Rossi Menezes; Diego Quattrone; Julio Sanjuán; Jean-Paul Selten; Andrea Tortelli; Pierre-Michel Llorca; Jim van Os; Bart P F Rutten; Robin M Murray; Craig Morgan; Marion Leboyer; Andrei Szöke; Franck Schürhoff Journal: Schizophr Bull Date: 2021-10-21 Impact factor: 9.306
Authors: Ilaria Tarricone; Giuseppe D'Andrea; Viviana Storbini; Mauro Braca; Silvia Ferrari; Corinna Reggianini; Marco Rigatelli; Carla Gramaglia; Patrizia Zeppegno; Eleonora Gambaro; Mario Luciano; Alessio Ceregato; Mario Altamura; Giuseppe Barrasso; Diego Primavera; Bernardo Carpiniello; Orlando Todarello; Vanna Berlincioni; Francesca Podavini; Craig Morgan; Robin M Murray; Marta Di Forti; Roberto Muratori; Domenico Berardi Journal: J Immigr Minor Health Date: 2021-03-10
Authors: Diego Quattrone; Ulrich Reininghaus; Alex L Richards; Giada Tripoli; Laura Ferraro; Andrea Quattrone; Paolo Marino; Victoria Rodriguez; Edoardo Spinazzola; Charlotte Gayer-Anderson; Hannah E Jongsma; Peter B Jones; Caterina La Cascia; Daniele La Barbera; Ilaria Tarricone; Elena Bonora; Sarah Tosato; Antonio Lasalvia; Andrei Szöke; Celso Arango; Miquel Bernardo; Julio Bobes; Cristina Marta Del Ben; Paulo Rossi Menezes; Pierre-Michel Llorca; Jose Luis Santos; Julio Sanjuán; Manuel Arrojo; Andrea Tortelli; Eva Velthorst; Steven Berendsen; Lieuwe de Haan; Bart P F Rutten; Michael T Lynskey; Tom P Freeman; James B Kirkbride; Pak C Sham; Michael C O'Donovan; Alastair G Cardno; Evangelos Vassos; Jim van Os; Craig Morgan; Robin M Murray; Cathryn M Lewis; Marta Di Forti Journal: Transl Psychiatry Date: 2021-08-10 Impact factor: 6.222
Authors: Laura Ferraro; Caterina La Cascia; Daniele La Barbera; Teresa Sanchez-Gutierrez; Giada Tripoli; Fabio Seminerio; Crocettarachele Sartorio; Giovanna Marrazzo; Lucia Sideli; Celso Arango; Manuel Arrojo; Miguel Bernardo; Julio Bobes; Cristina Marta Del-Ben; Charlotte Gayer-Anderson; Hannah E Jongsma; James B Kirkbride; Antonio Lasalvia; Sarah Tosato; Pierre-Michel Llorca; Paulo Rossi Menezes; Bart P Rutten; Jose Luis Santos; Julio Sanjuán; Jean-Paul Selten; Andrei Szöke; Ilaria Tarricone; Roberto Muratori; Andrea Tortelli; Eva Velthorst; Victoria Rodriguez; Andrea Quattrone; Peter B Jones; Jim Van Os; Evangelos Vassos; Craig Morgan; Lieuwe de Haan; Ulrich Reininghaus; Alastair G Cardno; Marta Di Forti; Robin M Murray; Diego Quattrone Journal: Schizophr Res Date: 2021-08-14 Impact factor: 4.939
Authors: Olesya Ajnakina; Victoria Rodriguez; Diego Quattrone; Marta di Forti; Evangelos Vassos; Celso Arango; Domenico Berardi; Miguel Bernardo; Julio Bobes; Lieuwe de Haan; Cristina Marta Del-Ben; Charlotte Gayer-Anderson; Hannah E Jongsma; Antonio Lasalvia; Sarah Tosato; Pierre-Michel Llorca; Paulo Rossi Menezes; Bart P Rutten; Jose Luis Santos; Julio Sanjuán; Jean-Paul Selten; Andrei Szöke; Ilaria Tarricone; Giuseppe D'Andrea; Alexander Richards; Andrea Tortelli; Eva Velthorst; Peter B Jones; Manuel Arrojo Romero; Caterina La Cascia; James B Kirkbride; Jim van Os; Mick O'Donovan; Robin M Murray Journal: Schizophr Bull Date: 2021-10-21 Impact factor: 9.306
Authors: Giada Tripoli; Diego Quattrone; Laura Ferraro; Charlotte Gayer-Anderson; Caterina La Cascia; Daniele La Barbera; Crocettarachele Sartorio; Fabio Seminerio; Victoria Rodriguez; Ilaria Tarricone; Domenico Berardi; Stéphane Jamain; Celso Arango; Andrea Tortelli; Pierre-Michel Llorca; Lieuwe de Haan; Eva Velthorst; Julio Bobes; Miquel Bernardo; Julio Sanjuán; Jose Luis Santos; Manuel Arrojo; Cristina Marta Del-Ben; Paulo Rossi Menezes; Els van der Ven; Peter B Jones; Hannah E Jongsma; James B Kirkbride; Sarah Tosato; Antonio Lasalvia; Alex Richards; Michael O'Donovan; Bart P F Rutten; Jim van Os; Craig Morgan; Pak C Sham; Marta Di Forti; Robin M Murray; Graham K Murray Journal: Schizophr Bull Date: 2022-09-01 Impact factor: 7.348