| Literature DB >> 31972215 |
Mahfuzur R Miah1, Omamuyovwi M Ijomone2, Comfort O A Okoh2, Olayemi K Ijomone3, Grace T Akingbade2, Tao Ke4, Bárbara Krum5, Airton da Cunha Martins4, Ayodele Akinyemi4, Nicole Aranoff6, Felix Alexandre Antunes Soares7, Aaron B Bowman8, Michael Aschner9.
Abstract
Manganese (Mn) is the twelfth most abundant element on the earth and an essential metal to human health. Mn is present at low concentrations in a variety of dietary sources, which provides adequate Mn content to sustain support various physiological processes in the human body. However, with the rise of Mn utility in a variety of industries, there is an increased risk of overexposure to this transition metal, which can have neurotoxic consequences. This risk includes occupational exposure of Mn to workers as well as overall increased Mn pollution affecting the general public. Here, we review exposure due to air pollution and inhalation in industrial settings; we also delve into the toxic effects of manganese on the brain such as oxidative stress, inflammatory response and transporter dysregulation. Additionally, we summarize current understandings underlying the mechanisms of Mn toxicity.Entities:
Keywords: Air pollution; Brain health; Manganese; Metal imbalance; Nervous system; Neurodegeneration; Neurotoxicity; Oxidative stress
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Year: 2020 PMID： 31972215 DOI： 10.1016/j.neuint.2020.104688
Source DB: PubMed Journal: Neurochem Int ISSN： 0197-0186 Impact factor: 3.921