OBJECTIVE: To determine the spectrum of phenotypes linked to the ABO blood group system, using genetic determinants of the ABO blood group system. Approach and Results: We assessed the risk of 41 health and disease outcomes, and 36 linear traits associated with the ABO blood group system in the UK Biobank cohort. A total of 406 755 unrelated individuals were included in this study. Blood groups A, B, and O were determined based on allele combinations of previously established single-nucleotide polymorphisms rs8176746, rs8176719 in the ABO gene. Group AB was excluded because of its relative small sample size. Overall, 187 387 (46%) were male with a mean (SD) age of 57±8.1 years and a median total exposure of 64 person-years (interquartile range, 57-70). Of 406 755 individuals, 182 621 (44.9%) participants had blood group O, 182 786 (44.9%) had blood group A, and 41 348 (10.2%) had blood group B. ABO blood groups were associated with 11 health and disease outcomes (P<2.19×10-4). ABO blood groups were primarily associated with cardiovascular outcomes. Compared with individuals with blood group O, blood groups A and B were associated with increased odds of up to 1.56 (95% CI, 1.43-1.69) for thromboembolic events and decreased odds for hypertension (0.94 [95% CI, 0.92-0.97]). CONCLUSIONS: The ABO blood group system is associated with several parameters of healthy aging and disease development. Knowledge of ABO blood groups might be of interest for more personalized approaches towards health maintenance and the prevention of diseases.
OBJECTIVE: To determine the spectrum of phenotypes linked to the ABO blood group system, using genetic determinants of the ABO blood group system. Approach and Results: We assessed the risk of 41 health and disease outcomes, and 36 linear traits associated with the ABO blood group system in the UK Biobank cohort. A total of 406 755 unrelated individuals were included in this study. Blood groups A, B, and O were determined based on allele combinations of previously established single-nucleotide polymorphisms rs8176746, rs8176719 in the ABO gene. Group AB was excluded because of its relative small sample size. Overall, 187 387 (46%) were male with a mean (SD) age of 57±8.1 years and a median total exposure of 64 person-years (interquartile range, 57-70). Of 406 755 individuals, 182 621 (44.9%) participants had blood group O, 182 786 (44.9%) had blood group A, and 41 348 (10.2%) had blood group B. ABO blood groups were associated with 11 health and disease outcomes (P<2.19×10-4). ABO blood groups were primarily associated with cardiovascular outcomes. Compared with individuals with blood group O, blood groups A and B were associated with increased odds of up to 1.56 (95% CI, 1.43-1.69) for thromboembolic events and decreased odds for hypertension (0.94 [95% CI, 0.92-0.97]). CONCLUSIONS: The ABO blood group system is associated with several parameters of healthy aging and disease development. Knowledge of ABO blood groups might be of interest for more personalized approaches towards health maintenance and the prevention of diseases.
Authors: Oliver Richards; Kirsten J Cromie; Christopher Akhunbay-Fudge; Neeraj Kalra; Richard G Feltbower; Paul Chumas; Ian A Anderson Journal: Acta Neurochir (Wien) Date: 2022-01-18 Impact factor: 2.216
Authors: Gie Ken-Dror; Ioana Cotlarciuc; Ida Martinelli; Elvira Grandone; Sini Hiltunen; Erik Lindgren; Maurizio Margaglione; Veronique Le Cam Duchez; Aude Bagan Triquenot; Marialuisa Zedde; Michelangelo Mancuso; Ynte M Ruigrok; Thomas Marjot; Brad Worrall; Jennifer J Majersik; Tiina M Metso; Jukka Putaala; Elena Haapaniemi; Susanna M Zuurbier; Matthijs C Brouwer; Serena M Passamonti; Maria Abbattista; Paolo Bucciarelli; Braxton D Mitchell; Steven J Kittner; Robin Lemmens; Christina Jern; Emanuela Pappalardo; Paolo Costa; Marina Colombi; Diana Aguiar de Sousa; Sofia Rodrigues; Patrícia Canhão; Aleksander Tkach; Rosa Santacroce; Giovanni Favuzzi; Antonio Arauz; Donatella Colaizzo; Kostas Spengos; Amanda Hodge; Reina Ditta; Alessandro Pezzini; Stephanie Debette; Jonathan M Coutinho; Vincent Thijs; Katarina Jood; Guillaume Pare; Turgut Tatlisumak; José M Ferro; Pankaj Sharma Journal: Ann Neurol Date: 2021-09-29 Impact factor: 10.422
Authors: Robert H George Markowitz; Abigail Leavitt LaBella; Mingjian Shi; Antonis Rokas; John A Capra; Jane F Ferguson; Jonathan D Mosley; Seth R Bordenstein Journal: Proc Natl Acad Sci U S A Date: 2022-06-24 Impact factor: 12.779
Authors: Linda Garvert; Bernhard T Baune; Klaus Berger; Dorret I Boomsma; Gerome Breen; Andreas Greinacher; Steven P Hamilton; Douglas F Levinson; Cathryn M Lewis; Susanne Lucae; Patrik K E Magnusson; Nicholas G Martin; Andrew M McIntosh; Ole Mors; Bertram Müller-Myhsok; Brenda W J H Penninx; Roy H Perlis; Giorgio Pistis; James B Potash; Martin Preisig; Marcella Rietschel; Jianxin Shi; Jordan W Smoller; Henning Tiemeier; Rudolf Uher; Uwe Völker; Henry Völzke; Myrna M Weissman; Hans J Grabe; Sandra Van der Auwera Journal: Psychiatry Res Date: 2021-02-24 Impact factor: 3.222
Authors: Tenghao Zheng; David Ellinghaus; Simonas Juzenas; Clemens Schafmayer; Mauro D'Amato; Andre Franke; François Cossais; Greta Burmeister; Gabriele Mayr; Isabella Friis Jørgensen; Maris Teder-Laving; Anne Heidi Skogholt; Sisi Chen; Peter R Strege; Go Ito; Karina Banasik; Thomas Becker; Frank Bokelmann; Søren Brunak; Stephan Buch; Hartmut Clausnitzer; Christian Datz; Frauke Degenhardt; Marek Doniec; Christian Erikstrup; Tõnu Esko; Michael Forster; Norbert Frey; Lars G Fritsche; Maiken Elvestad Gabrielsen; Tobias Gräßle; Andrea Gsur; Justus Gross; Jochen Hampe; Alexander Hendricks; Sebastian Hinz; Kristian Hveem; Johannes Jongen; Ralf Junker; Tom Hemming Karlsen; Georg Hemmrich-Stanisak; Wolfgang Kruis; Juozas Kupcinskas; Tilman Laubert; Philip C Rosenstiel; Christoph Röcken; Matthias Laudes; Fabian H Leendertz; Wolfgang Lieb; Verena Limperger; Nikolaos Margetis; Kerstin Mätz-Rensing; Christopher Georg Németh; Eivind Ness-Jensen; Ulrike Nowak-Göttl; Anita Pandit; Ole Birger Pedersen; Hans Günter Peleikis; Kenneth Peuker; Cristina Leal Rodriguez; Malte Christoph Rühlemann; Bodo Schniewind; Martin Schulzky; Jurgita Skieceviciene; Jürgen Tepel; Laurent Thomas; Florian Uellendahl-Werth; Henrik Ullum; Ilka Vogel; Henry Volzke; Lorenzo von Fersen; Witigo von Schönfels; Brett Vanderwerff; Julia Wilking; Michael Wittig; Sebastian Zeissig; Myrko Zobel; Matthew Zawistowski; Vladimir Vacic; Olga Sazonova; Elizabeth S Noblin; Gianrico Farrugia; Arthur Beyder; Thilo Wedel; Volker Kahlke Journal: Gut Date: 2021-04-22 Impact factor: 23.059
Authors: I Martynov; W Göpel; T K Rausch; C Härtel; A Franke; A R Franz; D Viemann; U H Thome; M Lacher; B W Ackermann Journal: Sci Rep Date: 2021-07-02 Impact factor: 4.379