Yiheng Tu1, Fang Zeng1, Lei Lan1, Zhengjie Li1, Nasim Maleki1, Bo Liu1, Jun Chen1, Chenchen Wang1, Joel Park1, Courtney Lang1, Gao Yujie1, Mailan Liu1, Zening Fu1, Zhiguo Zhang1, Fanrong Liang1, Jian Kong2. 1. From the Department of Psychiatry (Y.T., N.M., J.P., C.L., J.K.), Massachusetts General Hospital and Harvard Medical School, Charlestown; The Third Teaching Hospital (F.Z., L.L., Z.L., F.L.), Chengdu University of Traditional Chinese Medicine, Sichuan; Department of Radiology (B.L., J.C.), Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China; Center for Complementary and Integrative Medicine (C.W.), Division of Rheumatology, Tufts Medical Center, Boston, MA; Traditional Chinese Medicine School (G.Y), Ningxia Medical University, Yinchuan; The Acupuncture and Tuina School (M.L.), Hunan University of Traditional Chinese Medicine, Changsha, China; The Mind Research Network (Z.F.), Albuquerque, NM; and School of Biomedical Engineering (Z.Z.), Health Science Center, Shenzhen University, China. 2. From the Department of Psychiatry (Y.T., N.M., J.P., C.L., J.K.), Massachusetts General Hospital and Harvard Medical School, Charlestown; The Third Teaching Hospital (F.Z., L.L., Z.L., F.L.), Chengdu University of Traditional Chinese Medicine, Sichuan; Department of Radiology (B.L., J.C.), Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China; Center for Complementary and Integrative Medicine (C.W.), Division of Rheumatology, Tufts Medical Center, Boston, MA; Traditional Chinese Medicine School (G.Y), Ningxia Medical University, Yinchuan; The Acupuncture and Tuina School (M.L.), Hunan University of Traditional Chinese Medicine, Changsha, China; The Mind Research Network (Z.F.), Albuquerque, NM; and School of Biomedical Engineering (Z.Z.), Health Science Center, Shenzhen University, China. kongj@nmr.mgh.harvard.edu acuresearch@126.com.
Abstract
OBJECTIVE: To identify and validate an fMRI-based neural marker for migraine without aura (MwoA) and to examine its association with treatment response. METHODS: We conducted cross-sectional studies with resting-state fMRI data from 230 participants and machine learning analyses. In studies 1 through 3, we identified, cross-validated, independently validated, and cross-sectionally validated an fMRI-based neural marker for MwoA. In study 4, we assessed the relationship between the neural marker and treatment responses in migraineurs who received a 4-week real or sham acupuncture treatment, or were waitlisted, in a registered clinical trial. RESULTS: In study 1 (n = 116), we identified a neural marker with abnormal functional connectivity within the visual, default mode, sensorimotor, and frontal-parietal networks that could discriminate migraineurs from healthy controls (HCs) with 93% sensitivity and 89% specificity. In study 2 (n = 38), we investigated the generalizability of the marker by applying it to an independent cohort of migraineurs and HCs and achieved 84% sensitivity and specificity. In study 3 (n = 76), we verified the specificity of the marker with new datasets of migraineurs and patients with other chronic pain disorders (chronic low back pain and fibromyalgia) and demonstrated 78% sensitivity and 76% specificity for discriminating migraineurs from nonmigraineurs. In study 4 (n = 116), we found that the changes in the marker responses showed significant correlation with the changes in headache frequency in response to real acupuncture. CONCLUSION: We identified an fMRI-based neural marker that captures distinct characteristics of MwoA and can link disease pattern changes to brain changes.
OBJECTIVE: To identify and validate an fMRI-based neural marker for migraine without aura (MwoA) and to examine its association with treatment response. METHODS: We conducted cross-sectional studies with resting-state fMRI data from 230 participants and machine learning analyses. In studies 1 through 3, we identified, cross-validated, independently validated, and cross-sectionally validated an fMRI-based neural marker for MwoA. In study 4, we assessed the relationship between the neural marker and treatment responses in migraineurs who received a 4-week real or sham acupuncture treatment, or were waitlisted, in a registered clinical trial. RESULTS: In study 1 (n = 116), we identified a neural marker with abnormal functional connectivity within the visual, default mode, sensorimotor, and frontal-parietal networks that could discriminate migraineurs from healthy controls (HCs) with 93% sensitivity and 89% specificity. In study 2 (n = 38), we investigated the generalizability of the marker by applying it to an independent cohort of migraineurs and HCs and achieved 84% sensitivity and specificity. In study 3 (n = 76), we verified the specificity of the marker with new datasets of migraineurs and patients with other chronic pain disorders (chronic low back pain and fibromyalgia) and demonstrated 78% sensitivity and 76% specificity for discriminating migraineurs from nonmigraineurs. In study 4 (n = 116), we found that the changes in the marker responses showed significant correlation with the changes in headache frequency in response to real acupuncture. CONCLUSION: We identified an fMRI-based neural marker that captures distinct characteristics of MwoA and can link disease pattern changes to brain changes.
Authors: Andrew D Hershey; Paul Winner; Marielle A Kabbouche; Jack Gladstein; Marcy Yonker; Don Lewis; Eric Pearlman; Steven L Linder; A David Rothner; Scott W Powers Journal: Headache Date: 2005 Nov-Dec Impact factor: 5.887
Authors: Yiheng Tu; Ana Ortiz; Randy L Gollub; Jin Cao; Jessica Gerber; Courtney Lang; Joel Park; Georgia Wilson; Wei Shen; Suk-Tak Chan; Ajay D Wasan; Robert R Edwards; Vitaly Napadow; Ted J Kaptchuk; Bruce Rosen; Jian Kong Journal: Neuroimage Clin Date: 2019-05-28 Impact factor: 4.881
Authors: Brian J Douthit; Rachel L Walden; Kenrick Cato; Cynthia P Coviak; Christopher Cruz; Fabio D'Agostino; Thompson Forbes; Grace Gao; Theresa A Kapetanovic; Mikyoung A Lee; Lisiane Pruinelli; Mary A Schultz; Ann Wieben; Alvin D Jeffery Journal: Appl Clin Inform Date: 2022-02-09 Impact factor: 2.342