Faisal Mohammad Amin1, Anders Hougaard1, Stefano Magon1, Mohammad Sohail Asghar1, Nur Nabil Ahmad1, Egill Rostrup1, Till Sprenger1, Messoud Ashina2. 1. From the Danish Headache Center and Department of Neurology (F.M.A., A.H., M.S.A., N.N.A., M.A.) and the Functional Imaging Unit, Department of Clinical Physiology and Nuclear Medicine (E.R.), Rigshospitalet Glostrup, University of Copenhagen, Denmark; the Department of Neurology (S.M.), University Hospital Basel, Switzerland; and the Department of Neurology (T.S.), DKD Helios Klinik Wiesbaden, Germany. 2. From the Danish Headache Center and Department of Neurology (F.M.A., A.H., M.S.A., N.N.A., M.A.) and the Functional Imaging Unit, Department of Clinical Physiology and Nuclear Medicine (E.R.), Rigshospitalet Glostrup, University of Copenhagen, Denmark; the Department of Neurology (S.M.), University Hospital Basel, Switzerland; and the Department of Neurology (T.S.), DKD Helios Klinik Wiesbaden, Germany. ashina@dadlnet.dk.
Abstract
OBJECTIVE: To investigate resting-state functional connectivity in the salience network (SN), the sensorimotor network (SMN), and the default mode network (DMN) during migraine attacks induced by pituitary adenylate cyclase-activating polypeptide-38 (PACAP38). METHODS: In a double-blind, randomized study, 24 female migraine patients without aura receivedIV PACAP38 or vasoactive intestinal polypeptide (VIP) over 20 minutes. Both peptides are closely related and cause vasodilation, but only PACAP38 induces migraine attacks. VIP was therefore used as active placebo. Resting-state functional MRI was recorded before and during PACAP38-induced migraine attacks and before and after VIP infusion. We analyzed data by Statistical Parametric Mapping 8 and the Resting-State fMRI Data Analysis Toolkit for Matlab in a seed-based fashion. RESULTS:PACAP38 (n = 16) induced migraine attacks and increased connectivity with the bilateral opercular part of the inferior frontal gyrus in the SN. In SMN, there was increased connectivity with the right premotor cortex and decreased connectivity with the left visual cortex. Several areas showed increased (left primary auditory, secondary somatosensory, premotor, and visual cortices) and decreased (right cerebellum and left frontal lobe) connectivity with DMN. We found no resting-state network changes after VIP (n = 15). CONCLUSIONS:PACAP38-induced migraine attack is associated with altered connectivity of several large-scale functional networks of the brain.
RCT Entities:
OBJECTIVE: To investigate resting-state functional connectivity in the salience network (SN), the sensorimotor network (SMN), and the default mode network (DMN) during migraine attacks induced by pituitary adenylate cyclase-activating polypeptide-38 (PACAP38). METHODS: In a double-blind, randomized study, 24 female migrainepatients without aura received IV PACAP38 or vasoactive intestinal polypeptide (VIP) over 20 minutes. Both peptides are closely related and cause vasodilation, but only PACAP38 induces migraine attacks. VIP was therefore used as active placebo. Resting-state functional MRI was recorded before and during PACAP38-induced migraine attacks and before and after VIP infusion. We analyzed data by Statistical Parametric Mapping 8 and the Resting-State fMRI Data Analysis Toolkit for Matlab in a seed-based fashion. RESULTS: PACAP38 (n = 16) induced migraine attacks and increased connectivity with the bilateral opercular part of the inferior frontal gyrus in the SN. In SMN, there was increased connectivity with the right premotor cortex and decreased connectivity with the left visual cortex. Several areas showed increased (left primary auditory, secondary somatosensory, premotor, and visual cortices) and decreased (right cerebellum and left frontal lobe) connectivity with DMN. We found no resting-state network changes after VIP (n = 15). CONCLUSIONS: PACAP38-induced migraine attack is associated with altered connectivity of several large-scale functional networks of the brain.
Authors: Roberta Messina; Maria A Rocca; Bruno Colombo; Paola Valsasina; Alessandro Meani; Andrea Falini; Massimo Filippi Journal: J Neurol Date: 2019-11-19 Impact factor: 4.849
Authors: Anders Hougaard; Faisal Mohammad Amin; Henrik B W Larsson; Egill Rostrup; Messoud Ashina Journal: Hum Brain Mapp Date: 2017-02-27 Impact factor: 5.038