| Literature DB >> 31963885 |
Sok Kuan Wong1, Yusof Kamisah1, Norazlina Mohamed1, Norliza Muhammad1, Norliana Masbah1, Nur Azlina Mohd Fahami1, Isa Naina Mohamed1, Ahmad Nazun Shuid1, Qodriyah Mohd Saad1, Azman Abdullah1, Nur-Vaizura Mohamad1, Nurul' Izzah Ibrahim1, Kok-Lun Pang1, Yoke Yue Chow1, Benjamin Ka Seng Thong1, Shaanthana Subramaniam1, Chin Yi Chan1, Soelaiman Ima-Nirwana1, And Kok-Yong Chin1.
Abstract
<span class="Chemical">Tocotrienol (<span class="Chemical">T3) is a subfamily of vitamin E known for its wide array of medicinal properties. This review aimed to summarize the health benefits of T3, particularly in prevention or treatment of non-communicable diseases (NCDs), including cardiovascular, musculoskeletal, metabolic, gastric, and skin disorders, as well as cancers. Studies showed that T3 could prevent various NCDs, by suppressing 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) in the mevalonate pathway, inflammatory response, oxidative stress, and alternating hormones. The efficacy of T3 in preventing/treating these NCDs is similar or greater compared to tocopherol (TF). TF may lower the efficacy of T3 because the efficacy of the combination of TF and T3 was lower than T3 alone in some studies. Data investigating the effects of T3 on osteoporosis, arthritis, and peptic ulcers in human are limited. The positive outcomes of T3 treatment obtained from the preclinical studies warrant further validation from clinical trials.Entities:
Keywords: cancer; metabolic syndrome; musculoskeletal disease; osteoporosis; peptic ulcer; vitamin E
Year: 2020 PMID： 31963885 PMCID： PMC7019837 DOI： 10.3390/nu12010259
Source DB: PubMed Journal: Nutrients ISSN： 2072-6643 Impact factor: 5.717