Literature DB >> 3196162

Transfer of benzo(a)pyrene into mouse embryos and fetuses.

D Neubert1, S Tapken.   

Abstract

The distribution of radioactive material within maternal and embryonic/fetal mouse tissue was studied over a period of 2 days following a single dose of 14C-benzo(a)pyrene (B(a)P) orally on days 11, 12, 13 or 18 of pregnancy. B(a)P poorly penetrated into the embryo/fetus, and 14C-radioactivity was found in embryonic tissues at concentrations one to two orders of magnitude lower than in maternal organs. If the compound was administered for 3 consecutive days at the same dose the expected cumulation was compensated for by an accelerated elimination of the substance, which is probably due to enzyme induction.

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Year:  1988        PMID： 3196162     DOI： 10.1007/bf00570149

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  9 in total

1.  A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.

Authors:  K BURTON
Journal:  Biochem J       Date:  1956-02       Impact factor: 3.857

2.  Distribution and metabolism of benzo (a) pyrene in fetal mouse.

Authors:  G Takahashi
Journal:  Bull Chest Dis Res Inst Kyoto Univ       Date:  1974-03

3.  [Transplacental penetration of benz-(alpha)-pyrene in mice].

Authors:  I A Shendrikova; M N Ivanov-Golitsyn; A Ia Likhachev
Journal:  Vopr Onkol       Date:  1974-10

4.  Stimulatory effect of cigarette smoking on the hydroxylation of 3,4-benzpyrene and the N-demethylation of 3-methyl-4-monomethylaminoazobenzene by enzymes in human placenta.

Authors:  R M Welch; Y E Harrison; B W Gommi; P J Poppers; M Finster; A H Conney
Journal:  Clin Pharmacol Ther       Date:  1969 Jan-Feb       Impact factor: 6.875

5.  Effect of benzo( )pyrene treatment on the benzo( )pyrene hydroxylase activity in maternal liver, placenta, and fetus of the rat during day 13 to day 18 of gestation.

Authors:  E Schlede; H J Merker
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1972       Impact factor: 3.000

6.  Effect of maternal cigarette smoking on 3,4-benzpyrene and N-methylaniline metabolism in human fetal liver and placenta.

Authors:  O Pelkonen; P Jouppila; N T Kärki
Journal:  Toxicol Appl Pharmacol       Date:  1972-11       Impact factor: 4.219

7.  Carcinogenic effects of polycyclic hydrocarbon carcinogen administration to mice during pregnancy on the progeny.

Authors:  O M Bulay; L W Wattenberg
Journal:  J Natl Cancer Inst       Date:  1971-02       Impact factor: 13.506

8.  Cigarette smoking: stimulatory effect on metabolism of 3,4-benzpyrene by enzymes in human placenta.

Authors:  R M Welch; Y E Harrison; A H Conney; P J Poppers; M Finster
Journal:  Science       Date:  1968-05-03       Impact factor: 47.728

9.  Effect of smoking on benzo(a)pyrene metabolism by human placental microsomes.

Authors:  J B Vaught; H L Gurtoo; N B Parker; R LeBoeuf; G Doctor
Journal:  Cancer Res       Date:  1979-08       Impact factor: 12.701
  9 in total
  9 in total

1.  Prenatal induction of benzo(a)pyrene hydroxylases in mice.

Authors:  D Neubert; S Tapken
Journal:  Arch Toxicol       Date:  1988       Impact factor: 5.153

2.  The relationship between prenatal exposure to airborne polycyclic aromatic hydrocarbons (PAHs) and PAH-DNA adducts in cord blood.

Authors:  Wieslaw A Jedrychowski; Frederica P Perera; Deliang Tang; Virginia Rauh; Renata Majewska; Elzbieta Mroz; Elzbieta Flak; Laura Stigter; John Spengler; David Camann; Ryszard Jacek
Journal:  J Expo Sci Environ Epidemiol       Date:  2013-01-09       Impact factor: 5.563

3.  Levels of PAH-DNA adducts in cord blood and cord tissue and the risk of fetal neural tube defects in a Chinese population.

Authors:  Deqing Yi; Yue Yuan; Lei Jin; Guodong Zhou; Huiping Zhu; Richard H Finnell; Aiguo Ren
Journal:  Neurotoxicology       Date:  2014-12-15       Impact factor: 4.294

4.  Transplacental carcinogenesis with dibenzo[def,p]chrysene (DBC): timing of maternal exposures determines target tissue response in offspring.

Authors:  Lyndsey E Shorey; David J Castro; William M Baird; Lisbeth K Siddens; Christiane V Löhr; Melissa M Matzke; Katrina M Waters; Richard A Corley; David E Williams
Journal:  Cancer Lett       Date:  2011-11-13       Impact factor: 8.679

5.  Neighborhood Disadvantage Alters the Origins of Children's Nonaggressive Conduct Problems.

Authors:  S Alexandra Burt; Kelly L Klump; Deborah Gorman-Smith; Jenae M Neiderhiser
Journal:  Clin Psychol Sci       Date:  2016-01-13

6.  Prenatal exposure to airborne polycyclic aromatic hydrocarbons and children's intelligence at 5 years of age in a prospective cohort study in Poland.

Authors:  Susan Claire Edwards; Wieslaw Jedrychowski; Maria Butscher; David Camann; Agnieszka Kieltyka; Elzbieta Mroz; Elzbieta Flak; Zhigang Li; Shuang Wang; Virginia Rauh; Frederica Perera
Journal:  Environ Health Perspect       Date:  2010-04-14       Impact factor: 9.031

7.  Polycyclic aromatic hydrocarbons in maternal and umbilical cord blood from pregnant Hispanic women living in Brownsville, Texas.

Authors:  Ken Sexton; Jennifer J Salinas; Thomas J McDonald; Rose M Z Gowen; Rebecca P Miller; Joseph B McCormick; Susan P Fisher-Hoch
Journal:  Int J Environ Res Public Health       Date:  2011-08-17       Impact factor: 3.390

8.  Biomarkers in maternal and newborn blood indicate heightened fetal susceptibility to procarcinogenic DNA damage.

Authors:  Frederica P Perera; Deliang Tang; Yi-Hsuan Tu; Linda Ali Cruz; Mejico Borjas; Tom Bernert; Robin M Whyatt
Journal:  Environ Health Perspect       Date:  2004-07       Impact factor: 9.031

9.  Prenatal exposure to polycyclic aromatic hydrocarbons and cognitive dysfunction in children.

Authors:  Wiesław A Jedrychowski; Frederica P Perera; David Camann; John Spengler; Maria Butscher; Elzbieta Mroz; Renata Majewska; Elżbieta Flak; Ryszard Jacek; Agata Sowa
Journal:  Environ Sci Pollut Res Int       Date:  2014-09-26       Impact factor: 4.223
  9 in total

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