Literature DB >> 5644060

Cigarette smoking: stimulatory effect on metabolism of 3,4-benzpyrene by enzymes in human placenta.

R M Welch, Y E Harrison, A H Conney, P J Poppers, M Finster.   

Abstract

The enzymatic hydroxylation of 3,4-benzpyrene was not detected in human placentas obtained after childbirth from nonsmokers, whereas this enzyme activity was present in placentas obtained from individuals who smoked cigarettes. The degree of induction of benzpyrene hydroxylase caused by cigarette smoking varied in different individuals. Treatment of pregnant rats with benzpyrene increased the activity of this hydroxylase in the placenta.

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Year:  1968        PMID： 5644060     DOI： 10.1126/science.160.3827.541

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  25 in total

1.  Metabolism of [D10]phenanthrene to tetraols in smokers for potential lung cancer susceptibility assessment: comparison of oral and inhalation routes of administration.

Authors:  Yan Zhong; Jing Wang; Steven G Carmella; J Bradley Hochalter; Diane Rauch; Andrew Oliver; Joni Jensen; Dorothy K Hatsukami; Pramod Upadhyaya; Cheryl Zimmerman; Stephen S Hecht
Journal:  J Pharmacol Exp Ther       Date:  2011-04-22       Impact factor: 4.030

2.  Comparison of aryl hydrocarbon hydroxylase induction in cultured blood lymphocytes and pulmonary macrophages.

Authors:  T L McLemore; R R Martin; K L Toppell; D L Busbee; E T Cantrell
Journal:  J Clin Invest       Date:  1977-11       Impact factor: 14.808

3.  Cell-specific induction of mouse Cyp1a1 mRNA during development.

Authors:  A Dey; H Westphal; D W Nebert
Journal:  Proc Natl Acad Sci U S A       Date:  1989-10       Impact factor: 11.205

4.  Analysis of phenanthrene and benzo[a]pyrene tetraol enantiomers in human urine: relevance to the bay region diol epoxide hypothesis of benzo[a]pyrene carcinogenesis and to biomarker studies.

Authors:  Stephen S Hecht; Steven G Carmella; Peter W Villalta; J Bradley Hochalter
Journal:  Chem Res Toxicol       Date:  2010-05-17       Impact factor: 3.739

5.  The effect of cigarette smoking on drug metabolism in the liver and placenta: the use of cotinine in verifying smoking status.

Authors:  M Pasanen; K Vahakangas; E A Sotaniemi; O Pelkonen
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1988 Jan-Mar       Impact factor: 2.441

Review 6.  Role of tobacco smoking in pharmacokinetics.

Authors:  W J Jusko
Journal:  J Pharmacokinet Biopharm       Date:  1978-02

7.  [Demonstration of polycyclic aromatic hydrocarbon compounds in human neoplastic tissues].

Authors:  K H Wagner; I Siddiqi; E Wagner-Hering
Journal:  Naturwissenschaften       Date:  1970-11

8.  Benzo(a)pyrene hydroxylase activity in the whole implantation site, decidua, placenta and fetal membranes of the rat.

Authors:  E Schlede; H J Merker
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1974       Impact factor: 3.000

9.  Effect of benzo( )pyrene treatment on the benzo( )pyrene hydroxylase activity in maternal liver, placenta, and fetus of the rat during day 13 to day 18 of gestation.

Authors:  E Schlede; H J Merker
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1972       Impact factor: 3.000

10.  Pyrolysis products from amino acids and protein: highest mutagenicity requires cytochrome P1-450.

Authors:  D W Nebert; S W Bigelow; A B Okey; T Yahagi; Y Mori; M Nagao; T Sugimura
Journal:  Proc Natl Acad Sci U S A       Date:  1979-11       Impact factor: 11.205
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