| Literature DB >> 31952594 |
Pengfei Zou1, Wen-Hui Lee2, Zhiqin Gao3, Di Qin3, Yuxia Wang1, Jiao Liu1, Tongyi Sun4, Yuanyuan Gao5.
Abstract
Novel nanomaterials have been developed for antimicrobial and wound healing applications. Here, we report the preparation of a polyvinyl alcohol/chitosan (PVA/CS) nanofiber with carboxymethyl chitosan nanoparticles (CMCS-OH30 NPs) encapsulating the antibacterial peptide OH-CATH30 (OH-30). The PVA/CS nanofibers containing OH-30 NPs (NP-30-NFs) obtained via electrospinning could achieve a secondary embedded OH-30. The effect of NP-30-NFs on the release of OH-30 was investigated through high-performance liquid chromatography. The antibacterial activities of NP-30-NFs against Escherichia coli and Staphylococcus aureus were studied by bacterial plate counting. NP-30-NFs containing different concentrations of NPs were applied to mouse skin wounds to determine their effectiveness in promoting wound healing. Results showed that NP-30-NFs exhibited antibacterial properties and promoted skin wound healing.Entities:
Keywords: Nanofibers; Nanoparticles; OH-CATH30; PVA; Wound healing
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Year: 2019 PMID： 31952594 DOI： 10.1016/j.carbpol.2019.115786
Source DB: PubMed Journal: Carbohydr Polym ISSN： 0144-8617 Impact factor: 9.381