Literature DB >> 31951815

Expanding the Degradable Proteome: Designing PROTACs by the Book.

Martin G Jaeger1, Georg E Winter2.   

Abstract

In this issue of Cell Chemical Biology, Li et al. (2020), Hsu et al. (2020), and Potjewyd et al. (2020) expand the target spectrum amenable to protein degradation by designing degraders of the cell cycle checkpoint kinase Wee1 and the polycomb repressive complex 2 (PRC2) via its regulatory EED subunit.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Year:  2020        PMID: 31951815     DOI: 10.1016/j.chembiol.2019.12.009

Source DB:  PubMed          Journal:  Cell Chem Biol        ISSN: 2451-9448            Impact factor:   8.116


  3 in total

Review 1.  Critical Assessment of Targeted Protein Degradation as a Research Tool and Pharmacological Modality.

Authors:  Milka Kostic; Lyn H Jones
Journal:  Trends Pharmacol Sci       Date:  2020-03-26       Impact factor: 14.819

2.  Traceless Staudinger ligation enabled parallel synthesis of proteolysis targeting chimera linker variants.

Authors:  Troy A Bemis; James J La Clair; Michael D Burkart
Journal:  Chem Commun (Camb)       Date:  2021-01-06       Impact factor: 6.222

Review 3.  Targeted Protein Degradation as a Promising Tool for Epigenetic Upregulation of Fetal Hemoglobin.

Authors:  Thijs C J Verheul; Van Tuan Trinh; Olalla Vázquez; Sjaak Philipsen
Journal:  ChemMedChem       Date:  2020-11-04       Impact factor: 3.466

  3 in total

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