Literature DB >> 31951523

Siponimod Chips Away at Progressive MS.

Erin E Longbrake1, David A Hafler2.   

Abstract

Progressive multiple sclerosis (PMS) causes slow accumulation of neurologic disability and has been refractory to treatment with the immunomodulatory medications that effectively control relapsing MS. Siponimod modestly slowed the rate of disability progression among PMS patients who had inflammatory disease activity, evidenced by new or gadolinium-enhancing MRI lesions. To view this Bench to Bedside, open or download the PDF.
Copyright © 2019. Published by Elsevier Inc.

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Year:  2019        PMID: 31951523      PMCID: PMC8023412          DOI: 10.1016/j.cell.2019.11.034

Source DB:  PubMed          Journal:  Cell        ISSN: 0092-8674            Impact factor:   41.582


  3 in total

Review 1.  Progressive MS trials: Lessons learned.

Authors:  Carmen Tur; Xavier Montalban
Journal:  Mult Scler       Date:  2017-10       Impact factor: 6.312

2.  Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study.

Authors:  Ludwig Kappos; Amit Bar-Or; Bruce A C Cree; Robert J Fox; Gavin Giovannoni; Ralf Gold; Patrick Vermersch; Douglas L Arnold; Sophie Arnould; Tatiana Scherz; Christian Wolf; Erik Wallström; Frank Dahlke
Journal:  Lancet       Date:  2018-03-23       Impact factor: 79.321

3.  Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator.

Authors:  Shifeng Pan; Nathanael S Gray; Wenqi Gao; Yuan Mi; Yi Fan; Xing Wang; Tove Tuntland; Jianwei Che; Sophie Lefebvre; Yu Chen; Alan Chu; Klaus Hinterding; Anne Gardin; Peter End; Peter Heining; Christian Bruns; Nigel G Cooke; Barbara Nuesslein-Hildesheim
Journal:  ACS Med Chem Lett       Date:  2013-01-04       Impact factor: 4.345

  3 in total
  1 in total

Review 1.  A review of possible therapies for multiple sclerosis.

Authors:  Hui Li; Gaojian Lian; Guang Wang; Qianmei Yin; Zehong Su
Journal:  Mol Cell Biochem       Date:  2021-04-22       Impact factor: 3.396

  1 in total

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