INTRODUCTION: In lutetium-177 (Lu-177) single-photon emission computed tomography (SPECT) imaging, the accuracy of activity quantification is degraded by penetrated and scattered photons. We assessed the scattered photon fractions in order to determine the optimal situation and development of correction method. This study proposes to compare the image quality that can be achieved by three collimators. MATERIALS AND METHODS: Siemens Medical System Symbia fitted with high-energy (HE), medium-energy (ME), and low-energy high-resolution collimators was simulated using the SIMIND Monte Carlo code simulation code. Counts were collected in three different main-energy window widths (20%, 15%, and 10%) for Lu-177 point source. Primary and scattered point spread functions and also geometric, penetration, scattering were drawn and analyzed. RESULTS: In Lu-177 imaging, a 20% of main-energy window and ME collimator were found to be optimal. HE collimator can be used when the resolution is not required. CONCLUSION: These results provide the optimal energy window and collimator in Lu-177 SPECT imaging and will help the quantification of Lu-177. Copyright:
INTRODUCTION: In lutetium-177 (Lu-177) single-photon emission computed tomography (SPECT) imaging, the accuracy of activity quantification is degraded by penetrated and scattered photons. We assessed the scattered photon fractions in order to determine the optimal situation and development of correction method. This study proposes to compare the image quality that can be achieved by three collimators. MATERIALS AND METHODS: Siemens Medical System Symbia fitted with high-energy (HE), medium-energy (ME), and low-energy high-resolution collimators was simulated using the SIMIND Monte Carlo code simulation code. Counts were collected in three different main-energy window widths (20%, 15%, and 10%) for Lu-177 point source. Primary and scattered point spread functions and also geometric, penetration, scattering were drawn and analyzed. RESULTS: In Lu-177 imaging, a 20% of main-energy window and ME collimator were found to be optimal. HE collimator can be used when the resolution is not required. CONCLUSION: These results provide the optimal energy window and collimator in Lu-177 SPECT imaging and will help the quantification of Lu-177. Copyright:
Authors: Wouter A van der Zwan; Lisa Bodei; Jan Mueller-Brand; Wouter W de Herder; Larry K Kvols; Dik J Kwekkeboom Journal: Eur J Endocrinol Date: 2014-08-12 Impact factor: 6.664
Authors: Lisa Bodei; Marta Cremonesi; Chiara M Grana; Nicola Fazio; Simona Iodice; Silvia M Baio; Mirco Bartolomei; Dario Lombardo; Mahila E Ferrari; Maddalena Sansovini; Marco Chinol; Giovanni Paganelli Journal: Eur J Nucl Med Mol Imaging Date: 2011-09-03 Impact factor: 9.236
Authors: A Romer; D Seiler; N Marincek; P Brunner; M T Koller; Q K T Ng; H R Maecke; J Müller-Brand; C Rochlitz; M Briel; C Schindler; M A Walter Journal: Eur J Nucl Med Mol Imaging Date: 2013-10-02 Impact factor: 9.236
Authors: Emilio Mezzenga; Vincenzo D'Errico; Marco D'Arienzo; Lidia Strigari; Koutla Panagiota; Federica Matteucci; Stefano Severi; Giovanni Paganelli; Andrew Fenwick; David Bianchini; Francesco Marcocci; Anna Sarnelli Journal: PLoS One Date: 2017-08-14 Impact factor: 3.240