Literature DB >> 3194799

An eighth complementation group of rodent cells hypersensitive to ultraviolet radiation.

L H Thompson1, T Shiomi, E P Salazar, S A Stewart.   

Abstract

Two mutant lines (US31, US46) of mouse lymphoma cells that are hypersensitive to ultraviolet (UV) radiation were previously found to belong to different complementation groups. The mutants were tested for their ability to complement the six known complementation groups of UV-sensitive Chinese hamster ovary (CHO) cells, which are defective in nucleotide excision repair, as well as a seventh group represented by a V79 mutant. Hybrid cells were produced by fusion with polyethylene glycol and tested in situ for UV resistance. The mouse mutant US46 complemented all CHO mutants except UV61. Therefore, US46 is assigned to the same complementation group as UV61, and it is probably defective in the same locus. The mouse mutant US31 produced UV-resistant hybrid cells in each of the seven crosses, indicating that it forms an eighth complementation group among the rodent mutants. Thus, at least eight genes are likely required to repair UV damage in rodent cells.

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Mesh：

Year:  1988        PMID： 3194799     DOI： 10.1007/bf01535314

Source DB:  PubMed          Journal:  Somat Cell Mol Genet        ISSN： 0740-7750


  17 in total

1.  Complementation of a DNA repair defect in xeroderma pigmentosum cells by transfer of human chromosome 9.

Authors:  G P Kaur; R S Athwal
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

2.  Correction of xeroderma pigmentosum complementation group D mutant cell phenotypes by chromosome and gene transfer: involvement of the human ERCC2 DNA repair gene.

Authors:  W L Flejter; L D McDaniel; D Johns; E C Friedberg; R A Schultz
Journal:  Proc Natl Acad Sci U S A       Date:  1992-01-01       Impact factor: 11.205

3.  Molecular cloning of the human DNA excision repair gene ERCC-6.

Authors:  C Troelstra; H Odijk; J de Wit; A Westerveld; L H Thompson; D Bootsma; J H Hoeijmakers
Journal:  Mol Cell Biol       Date:  1990-11       Impact factor: 4.272

4.  Molecular cloning and biological characterization of the human excision repair gene ERCC-3.

Authors:  G Weeda; R C van Ham; R Masurel; A Westerveld; H Odijk; J de Wit; D Bootsma; A J van der Eb; J H Hoeijmakers
Journal:  Mol Cell Biol       Date:  1990-06       Impact factor: 4.272

Review 5.  Identification of human genes involved in repair and tolerance of DNA damage.

Authors:  B Kaina; G Fritz; T Coquerelle
Journal:  Radiat Environ Biophys       Date:  1991       Impact factor: 1.925

6.  Human chromosome 5 complements the DNA double-strand break-repair deficiency and gamma-ray sensitivity of the XR-1 hamster variant.

Authors:  A J Giaccia; N Denko; R MacLaren; D Mirman; C Waldren; I Hart; T D Stamato
Journal:  Am J Hum Genet       Date:  1990-09       Impact factor: 11.025

7.  RAD25 (SSL2), the yeast homolog of the human xeroderma pigmentosum group B DNA repair gene, is essential for viability.

Authors:  E Park; S N Guzder; M H Koken; I Jaspers-Dekker; G Weeda; J H Hoeijmakers; S Prakash; L Prakash
Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-01       Impact factor: 11.205

8.  The Schizosaccharomyces pombe rhp3+ gene required for DNA repair and cell viability is functionally interchangeable with the RAD3 gene of Saccharomyces cerevisiae.

Authors:  P R Reynolds; S Biggar; L Prakash; S Prakash
Journal:  Nucleic Acids Res       Date:  1992-05-11       Impact factor: 16.971

9.  Human chromosome 15 confers partial complementation of phenotypes to xeroderma pigmentosum group F cells.

Authors:  P J Saxon; R A Schultz; E J Stanbridge; E C Friedberg
Journal:  Am J Hum Genet       Date:  1989-04       Impact factor: 11.025

10.  Structure and expression of the excision repair gene ERCC6, involved in the human disorder Cockayne's syndrome group B.

Authors:  C Troelstra; W Hesen; D Bootsma; J H Hoeijmakers
Journal:  Nucleic Acids Res       Date:  1993-02-11       Impact factor: 16.971
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