Literature DB >> 319459

Nonsense suppressors of yeast cause osmotic-sensitive growth.

A Singh.   

Abstract

Many nonsense suppressors of Saccharomyces cerevisiae cause growth inhibition on hypertonic media. Eight tyrosine-inserting UAA (ochre) suppressors, eight tyrosine-inserting UAG (amber) suppressors, a leucine-inserting UAG suppressor, and a serine-inserting recessive lethal UAG suppressor cause osmotic sensitivity, whereas a serine-inserting UAA suppressor does not cause sensitivity. Although the mechanism is not understood, the growth inhibition of specific suppressors on hypertonic media is correlated with their efficiencies of suppression. This heretofore unknown property of nonsense suppressors is useful for mitotic mapping, selecting tRNA mutants, selecting antisuppressors, and scoring nonsense suppressors.

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Year:  1977        PMID： 319459      PMCID： PMC393248          DOI： 10.1073/pnas.74.1.305

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  18 in total

1.  RESPIRATION-DEFICIENT MUTANTS OF YEAST. II. BIOCHEMISTRY.

Authors:  F SHERMAN; P P SLONIMSKI
Journal:  Biochim Biophys Acta       Date:  1964-07-15

2.  STREPTOMYCIN, SUPPRESSION, AND THE CODE.

Authors:  J DAVIES; W GILBERT; L GORINI
Journal:  Proc Natl Acad Sci U S A       Date:  1964-05       Impact factor: 11.205

3.  Temperature-sensitive, osmotic-remedial mutants of Neurospora crassa: osmotic pressure induced alterations of enzyme stability.

Authors:  C E Martin; A G DeBusk
Journal:  Mol Gen Genet       Date:  1975

Review 4.  Suppressors in yeast.

Authors:  D C Hawthorne; U Leupold
Journal:  Curr Top Microbiol Immunol       Date:  1974       Impact factor: 4.291

5.  Tyrosine substitutions resulting from suppression of amber mutants of iso-1-cytochrome c in yeast.

Authors:  F Sherman; S W Liebman; J W Stewart; M Jackson
Journal:  J Mol Biol       Date:  1973-06-25       Impact factor: 5.469

6.  The mutational alteration of the primary structure of yeast iso-1-cytochrome c.

Authors:  F Sherman; J W Stewart; J H Parker; E Inhaber; N A Shipman; G J Putterman; R L Gardisky; E Margoliash
Journal:  J Biol Chem       Date:  1968-10-25       Impact factor: 5.157

7.  Amino acid replacements resulting from super-suppression of nonsense mutants of iso-1-cytochrome c from yeast.

Authors:  R A Gilmore; J W Stewart; F Sherman
Journal:  J Mol Biol       Date:  1971-10-14       Impact factor: 5.469

8.  Repair of multiple defects of a regulatory mutant of Neurospora by high osmotic pressure and by reversion.

Authors:  R L Metzenberg
Journal:  Arch Biochem Biophys       Date:  1968-05       Impact factor: 4.013

9.  A recessive lethal super-suppressor mutation in yeast and other psi phenomena.

Authors:  B S Cox
Journal:  Heredity (Edinb)       Date:  1971-04       Impact factor: 3.821

10.  Yeast super-suppressors are altered tRNAs capable of translating a nonsense codon in vitro.

Authors:  M R Capecchi; S H Hughes; G M Wahl
Journal:  Cell       Date:  1975-11       Impact factor: 41.582
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  17 in total

1.  Gene overexpression as a tool for identifying new trans-acting factors involved in translation termination in Saccharomyces cerevisiae.

Authors:  Olivier Namy; Isabelle Hatin; Guillaume Stahl; Hongmei Liu; Stephanie Barnay; Laure Bidou; Jean-Pierre Rousset
Journal:  Genetics       Date:  2002-06       Impact factor: 4.562

2.  The tRNA-Tyr gene family of Saccharomyces cerevisiae: agents of phenotypic variation and position effects on mutation frequency.

Authors:  Sayoko Ito-Harashima; Phillip E Hartzog; Himanshu Sinha; John H McCusker
Journal:  Genetics       Date:  2002-08       Impact factor: 4.562

3.  A halotolerant mutant of Saccharomyces cerevisiae.

Authors:  R Gaxiola; M Corona; S Zinker
Journal:  J Bacteriol       Date:  1996-05       Impact factor: 3.490

4.  A position effect on the expression of a tRNA gene mediated by the SIR genes in Saccharomyces cerevisiae.

Authors:  R Schnell; J Rine
Journal:  Mol Cell Biol       Date:  1986-02       Impact factor: 4.272

5.  Deletions of the iso-1-cytochrome c and adjacent genes of yeast: discovery of the OSM1 gene controlling osmotic sensitivity.

Authors:  A Singh; F Sherman
Journal:  Genetics       Date:  1978-08       Impact factor: 4.562

6.  Alanine-scanning mutagenesis of protein phosphatase type 1 in the yeast Saccharomyces cerevisiae.

Authors:  S H Baker; D L Frederick; A Bloecher; K Tatchell
Journal:  Genetics       Date:  1997-03       Impact factor: 4.562

7.  Mutation of the non-Mendelian suppressor, Psi, in yeast by hypertonic media.

Authors:  A Singh; C Helms; F Sherman
Journal:  Proc Natl Acad Sci U S A       Date:  1979-04       Impact factor: 11.205

8.  Isolation and genetic analysis of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and alpha factor pheromones.

Authors:  R K Chan; C A Otte
Journal:  Mol Cell Biol       Date:  1982-01       Impact factor: 4.272

9.  Sequences that regulate the divergent GAL1-GAL10 promoter in Saccharomyces cerevisiae.

Authors:  M Johnston; R W Davis
Journal:  Mol Cell Biol       Date:  1984-08       Impact factor: 4.272

10.  crl mutants of Saccharomyces cerevisiae resemble both mutants affecting general control of amino acid biosynthesis and omnipotent translational suppressor mutants.

Authors:  J H McCusker; J E Haber
Journal:  Genetics       Date:  1988-06       Impact factor: 4.562
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