Tomás Patrick Griffin1,2, Deirdre Wall3, Liam Blake4, Damian Gerard Griffin2,4, Stephaine M Robinson5, Marcia Bell2, Eamon C Mulkerrin5, Paula M O'Shea4. 1. Regenerative Medicine Institute at CÚRAM SFI Research Centre, School of Medicine, National University of Ireland Galway. 2. Centre for Endocrinology, Diabetes and Metabolism, Galway University Hospitals. 3. School of Mathematics, Statistics and Applied Mathematics, National University of Ireland Galway. 4. Department of Clinical Biochemistry, Galway University Hospitals. 5. Department of Geriatric Medicine, Galway University Hospitals, Ireland.
Abstract
BACKGROUND: Approximately 1 billion people worldwide have Vitamin D deficiency. The aim of this study was to compare Vitamin D status and serum 25-hydroxyvitamin D (25(OH)D) concentrations among adults sampled in the community, in outpatient clinics, as hospital inpatients and in nursing homes in the West of Ireland. The secondary aim was to determine the associations between length of hospital stay (inpatients) at the time of serum 25(OH)D sampling and Vitamin D status. METHODS: A cross-sectional study was carried out. Patients who had serum 25(OH)D analysis carried out in Galway University Hospitals (January 2011-December 2015) were identified following interrogation of the electronic laboratory data system. Baseline demographics, location, and date of sample collection were recorded. Vitamin D deficiency was defined as a serum 25(OH)D concentration <25 nmol/L. RESULTS: In total, 24,302 patient samples were eligible for inclusion: community 15,319; outpatient clinics 6,371; inpatients 2,339; and nursing home residents 273. Vitamin D deficiency was more common in nursing home residents than inpatients, or those sampled in outpatient clinics or in the community (42% vs 37% vs 17% vs 13%; p < .001). Inpatients sampled further into their hospital stay (≥3 days) had greater Vitamin D deficiency than inpatients sampled on 0-2 days (p = .007). Season (p < .001), sex (p < .001), and age (p < .001) were associated with 25(OH)D concentrations. Vitamin D deficiency was more common in Winter/Spring, in males, and in those aged ≥80 years. CONCLUSIONS: Nursing home residents and inpatients are at the highest risk for Vitamin D deficiency. Season, sex, age, and day of hospital stay on which serum 25(OH)D concentrations were sampled were associated with Vitamin D status.
BACKGROUND: Approximately 1 billion people worldwide have Vitamin Ddeficiency. The aim of this study was to compare Vitamin D status and serum 25-hydroxyvitamin D (25(OH)D) concentrations among adults sampled in the community, in outpatient clinics, as hospital inpatients and in nursing homes in the West of Ireland. The secondary aim was to determine the associations between length of hospital stay (inpatients) at the time of serum 25(OH)D sampling and Vitamin D status. METHODS: A cross-sectional study was carried out. Patients who had serum 25(OH)D analysis carried out in Galway University Hospitals (January 2011-December 2015) were identified following interrogation of the electronic laboratory data system. Baseline demographics, location, and date of sample collection were recorded. Vitamin Ddeficiency was defined as a serum 25(OH)D concentration <25 nmol/L. RESULTS: In total, 24,302 patient samples were eligible for inclusion: community 15,319; outpatient clinics 6,371; inpatients 2,339; and nursing home residents 273. Vitamin Ddeficiency was more common in nursing home residents than inpatients, or those sampled in outpatient clinics or in the community (42% vs 37% vs 17% vs 13%; p < .001). Inpatients sampled further into their hospital stay (≥3 days) had greater Vitamin Ddeficiency than inpatients sampled on 0-2 days (p = .007). Season (p < .001), sex (p < .001), and age (p < .001) were associated with 25(OH)D concentrations. Vitamin Ddeficiency was more common in Winter/Spring, in males, and in those aged ≥80 years. CONCLUSIONS: Nursing home residents and inpatients are at the highest risk for Vitamin Ddeficiency. Season, sex, age, and day of hospital stay on which serum 25(OH)D concentrations were sampled were associated with Vitamin D status.
Authors: Orlagh Feehan; David J Armstrong; Pamela J Magee; Kirsty L Pourshahidi; J J Strain; Laura Beggan; Diego F Cobice; Emeir M McSorley Journal: Nutrients Date: 2022-06-28 Impact factor: 6.706
Authors: Paula M O'Shea; Graham Robert Lee; Tomás P Griffin; Vincent Tormey; Amjad Hayat; Seán J Costelloe; Damian Gerard Griffin; Saradha Srinivasan; Maurice O'Kane; Conor M Burke; John Faul; Christopher J Thompson; Gerard Curley; William P Tormey Journal: Ir J Med Sci Date: 2020-05-18 Impact factor: 1.568
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Authors: Tomás P Griffin; Caroline M Joyce; Sumaya Alkanderi; Liam M Blake; Derek T O'Keeffe; Delia Bogdanet; Md Nahidul Islam; Michael C Dennedy; John E Gillan; John J Morrison; Timothy O'Brien; John A Sayer; Marcia Bell; Paula M O'Shea Journal: Endocr Connect Date: 2020-06 Impact factor: 3.335
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