Michelle Louise Headland1,2,3, Peter Marshall Clifton1,2,3, Jennifer Beatrice Keogh4,5,6. 1. School of Pharmacy and Medical Sciences, Division of Health Sciences, University of South Australia, Adelaide, SA, Australia. 2. Alliance for Research in Exercise, Nutrition and Activity (ARENA), Adelaide, SA, Australia. 3. Sansom Institute for Health Research, Adelaide, SA, Australia. 4. School of Pharmacy and Medical Sciences, Division of Health Sciences, University of South Australia, Adelaide, SA, Australia. jennifer.keogh@unisa.edu.au. 5. Alliance for Research in Exercise, Nutrition and Activity (ARENA), Adelaide, SA, Australia. jennifer.keogh@unisa.edu.au. 6. Sansom Institute for Health Research, Adelaide, SA, Australia. jennifer.keogh@unisa.edu.au.
Abstract
BACKGROUND AND OBJECTIVE: Intermittent energy restriction continues to gain popularity as a weight loss strategy; however, data assessing it's long-term viability is limited. The objective of this study was to follow up with participants 12 months after they had completed a 12-month dietary intervention trial involvingcontinuous energy restriction and two forms of intermittent energy restriction; a week-on-week-off energy restriction and a 5:2 programme, assessing long-term changes on weight, body composition, blood lipids and glucose. SUBJECTS AND METHODS: 109 overweight and obese adults, aged 18-72 years, attended a 12-month follow-up after completing a 12-month dietary intervention involving three groups: continuous energy restriction (1000 kcal/day for women and 1200 kcal/day for men), week-on-week-off energy restriction (alternating between the same energy restriction as the continuous group for one week and one week of habitual diet), or 5:2 (500 kcal/day on modified fast days each week for women and 600 kcal/day for men). The primary outcome was weight change at 24 months from baseline, with secondary outcomes of change in body composition, blood lipids and glucose. RESULTS: For the 109 individuals who completed the 12-month follow-up (82 female, 15 male, mean BMI 33 kg/m2), weight decreased over time with no differences between week-on and week-off and continuous energy restriction or 5:2 and continuous energy restriction with -4.5 ± 4.9 kg for continuous energy restriction, -2.8 ± 6.5 kg for week-on, week-off and -3.5 ± 5.1 kg for 5:2. Total cholesterol reduced over time and glucose, HDL, LDL and triglycerides were unchanged. DISCUSSION AND CONCLUSION: Intermittent energy restriction was as successful in achieving modest weight loss over a 24-month period as continuous energy restriction.
RCT Entities:
BACKGROUND AND OBJECTIVE: Intermittent energy restriction continues to gain popularity as a weight loss strategy; however, data assessing it's long-term viability is limited. The objective of this study was to follow up with participants 12 months after they had completed a 12-month dietary intervention trial involving continuous energy restriction and two forms of intermittent energy restriction; a week-on-week-off energy restriction and a 5:2 programme, assessing long-term changes on weight, body composition, blood lipids and glucose. SUBJECTS AND METHODS: 109 overweight and obese adults, aged 18-72 years, attended a 12-month follow-up after completing a 12-month dietary intervention involving three groups: continuous energy restriction (1000 kcal/day for women and 1200 kcal/day for men), week-on-week-off energy restriction (alternating between the same energy restriction as the continuous group for one week and one week of habitual diet), or 5:2 (500 kcal/day on modified fast days each week for women and 600 kcal/day for men). The primary outcome was weight change at 24 months from baseline, with secondary outcomes of change in body composition, blood lipids and glucose. RESULTS: For the 109 individuals who completed the 12-month follow-up (82 female, 15 male, mean BMI 33 kg/m2), weight decreased over time with no differences between week-on and week-off and continuous energy restriction or 5:2 and continuous energy restriction with -4.5 ± 4.9 kg for continuous energy restriction, -2.8 ± 6.5 kg for week-on, week-off and -3.5 ± 5.1 kg for 5:2. Total cholesterol reduced over time and glucose, HDL, LDL and triglycerides were unchanged. DISCUSSION AND CONCLUSION: Intermittent energy restriction was as successful in achieving modest weight loss over a 24-month period as continuous energy restriction.
Authors: John F Trepanowski; Cynthia M Kroeger; Adrienne Barnosky; Monica C Klempel; Surabhi Bhutani; Kristin K Hoddy; Kelsey Gabel; Sally Freels; Joseph Rigdon; Jennifer Rood; Eric Ravussin; Krista A Varady Journal: JAMA Intern Med Date: 2017-07-01 Impact factor: 21.873
Authors: Michelle Harvie; Claire Wright; Mary Pegington; Debbie McMullan; Ellen Mitchell; Bronwen Martin; Roy G Cutler; Gareth Evans; Sigrid Whiteside; Stuart Maudsley; Simonetta Camandola; Rui Wang; Olga D Carlson; Josephine M Egan; Mark P Mattson; Anthony Howell Journal: Br J Nutr Date: 2013-04-16 Impact factor: 3.718
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