Literature DB >> 31932380

Minocycline-EDTA-Ethanol Antimicrobial Catheter Lock Solution Is Highly Effective In Vitro for Eradication of Candida auris Biofilms.

Ruth A Reitzel1, Joel Rosenblatt2, Bahgat Z Gerges2, Nylev Vargas-Cruz2, Issam I Raad2.   

Abstract

Candida auris is an emerging pathogen that can cause virulent central-line-associated bloodstream infections. Catheter salvage through the eradication of biofilms is a desirable therapeutic option. We compared taurolidine and minocycline-EDTA-ethanol (MEE) catheter lock solutions in vitro for the eradication of biofilms of 10 C. auris strains. MEE fully eradicated all C. auris biofilms, while taurolidine lock partially eradicated all of the C. auris biofilms. The superiority was significant for all C. auris strains tested (P = 0.002).
Copyright © 2020 American Society for Microbiology.

Entities:  

Keywords:  Candida auris; antimicrobial agents; biofilm; catheter lock solution; minocycline-EDTA-ethanol

Mesh：

Substances：

Year:  2020        PMID： 31932380      PMCID： PMC7179321          DOI： 10.1128/AAC.02146-19

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

1.  Taurolidine lock: the key to prevention of recurrent catheter-related bloodstream infections.

Authors:  Brian Jurewitsch; Khursheed N Jeejeebhoy
Journal:  Clin Nutr       Date:  2005-04-22       Impact factor: 7.324

2.  Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 Update by the Infectious Diseases Society of America.

Authors:  Leonard A Mermel; Michael Allon; Emilio Bouza; Donald E Craven; Patricia Flynn; Naomi P O'Grady; Issam I Raad; Bart J A Rijnders; Robert J Sherertz; David K Warren
Journal:  Clin Infect Dis       Date:  2009-07-01       Impact factor: 9.079

Review 3.  Candida auris: a Review of the Literature.

Authors:  Anna Jeffery-Smith; Surabhi K Taori; Silke Schelenz; Katie Jeffery; Elizabeth M Johnson; Andrew Borman; Rohini Manuel; Colin S Brown
Journal:  Clin Microbiol Rev       Date:  2017-11-15       Impact factor: 26.132

Review 4.  The Candida auris Alert: Facts and Perspectives.

Authors:  Frederic Lamoth; Dimitrios P Kontoyiannis
Journal:  J Infect Dis       Date:  2018-01-30       Impact factor: 5.226

5.  A multicentre study of antifungal susceptibility patterns among 350 Candida auris isolates (2009-17) in India: role of the ERG11 and FKS1 genes in azole and echinocandin resistance.

Authors:  Anuradha Chowdhary; Anupam Prakash; Cheshta Sharma; Milena Kordalewska; Anil Kumar; Smita Sarma; Bansidhar Tarai; Ashutosh Singh; Gargi Upadhyaya; Shalini Upadhyay; Priyanka Yadav; Pradeep K Singh; Vikas Khillan; Neelam Sachdeva; David S Perlin; Jacques F Meis
Journal:  J Antimicrob Chemother       Date:  2018-04-01       Impact factor: 5.790

6.  Antifungal susceptibility of Candida biofilms: unique efficacy of amphotericin B lipid formulations and echinocandins.

Authors:  D M Kuhn; T George; J Chandra; P K Mukherjee; M A Ghannoum
Journal:  Antimicrob Agents Chemother       Date:  2002-06       Impact factor: 5.191

7.  A Novel Nonantibiotic Nitroglycerin-Based Catheter Lock Solution for Prevention of Intraluminal Central Venous Catheter Infections in Cancer Patients.

Authors:  Anne-Marie Chaftari; Ray Hachem; Ariel Szvalb; Mahnaz Taremi; Bruno Granwehr; George Michael Viola; Sapna Amin; Andrew Assaf; Yazan Numan; Pankil Shah; Ketevan Gasitashvili; Elizabeth Natividad; Ying Jiang; Rebecca Slack; Ruth Reitzel; Joel Rosenblatt; Elie Mouhayar; Issam Raad
Journal:  Antimicrob Agents Chemother       Date:  2017-06-27       Impact factor: 5.191

8.  Optimal antimicrobial catheter lock solution, using different combinations of minocycline, EDTA, and 25-percent ethanol, rapidly eradicates organisms embedded in biofilm.

Authors:  Issam Raad; Hend Hanna; Tanya Dvorak; Gassan Chaiban; Ray Hachem
Journal:  Antimicrob Agents Chemother       Date:  2006-10-30       Impact factor: 5.191

9.  Absence of microbial adaptation to taurolidine in patients on home parenteral nutrition who develop catheter related bloodstream infections and use taurolidine locks.

Authors:  E D Olthof; R J Rentenaar; A J M M Rijs; G J A Wanten
Journal:  Clin Nutr       Date:  2012-12-05       Impact factor: 7.324

10.  Taurolidine locks significantly reduce the incidence of catheter-related blood stream infections in high-risk patients on home parenteral nutrition.

Authors:  J Saunders; M Naghibi; Z Leach; C Parsons; A King; T Smith; M Stroud
Journal:  Eur J Clin Nutr       Date:  2014-03-19       Impact factor: 4.016
View more
  1 in total

Review 1.  Antifungal lock therapy: an eternal promise or an effective alternative therapeutic approach?

Authors:  R Kovács; L Majoros
Journal:  Lett Appl Microbiol       Date:  2022-01-30       Impact factor: 2.813
  1 in total

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