Qianqian Zhang1, Xiaona Li1, Xin Liu2, Moran Dong2, Jianpeng Xiao2, Jing Wang3, Mengya Zhou4, Yiding Wang4, Dan Ning2, Wenjun Ma2, Wei Zhu5, Tao Liu6, Bo Zhang7. 1. Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, Guangdong, China. 2. Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, 511430, Guangdong, China. 3. Institute of Public Health Service Testing, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, 511430, Guangdong, China. 4. Food Safety and Health Research Center, School of Public Health, Southern Medical University, Guangzhou, 510515, Guangdong, China. 5. Department of Toxicology, Guangzhou Center for Disease Control and Prevention, Guangzhou, 510440, Guangdong, China. 6. Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, 511430, Guangdong, China. Electronic address: gztt_2002@163.com. 7. Food Safety and Health Research Center, School of Public Health, Southern Medical University, Guangzhou, 510515, Guangdong, China. Electronic address: zhangbo2018@smu.edu.cn.
Abstract
BACKGROUND: A small number of epidemiological studies have suggested the association of antimony (Sb) exposure with type 2 diabetes risk. However, little is known about the relationship between Sb exposure during pregnancy and risk of gestational diabetes mellitus (GDM). OBJECTIVES: To investigate the associations of urinary Sb concentrations with GDM risk and blood glucose levels in pregnant women. METHODS: We analyzed the baseline data of 1789 pregnant women enrolled in the Birth Cohort Study on Prenatal Environments and Offspring Health (PEOH) in Guangzhou, China. Sb concentrations in urine were measured by inductively coupled plasma mass spectrometry (ICP-MS). Logistic regression and analysis of covariance were used to evaluate associations of Sb exposure with GDM risk and blood glucose levels. RESULTS: A total of 437 (24.4%) women were diagnosed with GDM. The relative risk of GDM for women in the highest quartile of creatinine-corrected Sb (CC-Sb) concentrations was 1.55 [RR (95% CI) = 1.55 (1.12, 2.15), p-trend = 0.005], compared with women in the lowest quartile. Moreover, the women in the top quartile of CC-Sb levels had a 5.2% higher 1 h blood glucose and a 4.2% higher 2 h blood glucose than those in the bottom quartile. We also found an interactive effect between maternal age and CC-Sb on the risk of GDM (p-interaction < 0.001). CONCLUSION: This study suggested significant positive associations of Sb exposure with increased GDM risk and impaired blood glucose homeostasis in pregnant women, and the Sb-GDM association might be modified by maternal age.
BACKGROUND: A small number of epidemiological studies have suggested the association of antimony (Sb) exposure with type 2 diabetes risk. However, little is known about the relationship between Sb exposure during pregnancy and risk of gestational diabetes mellitus (GDM). OBJECTIVES: To investigate the associations of urinary Sb concentrations with GDM risk and blood glucose levels in pregnant women. METHODS: We analyzed the baseline data of 1789 pregnant women enrolled in the Birth Cohort Study on Prenatal Environments and Offspring Health (PEOH) in Guangzhou, China. Sb concentrations in urine were measured by inductively coupled plasma mass spectrometry (ICP-MS). Logistic regression and analysis of covariance were used to evaluate associations of Sb exposure with GDM risk and blood glucose levels. RESULTS: A total of 437 (24.4%) women were diagnosed with GDM. The relative risk of GDM for women in the highest quartile of creatinine-corrected Sb (CC-Sb) concentrations was 1.55 [RR (95% CI) = 1.55 (1.12, 2.15), p-trend = 0.005], compared with women in the lowest quartile. Moreover, the women in the top quartile of CC-Sb levels had a 5.2% higher 1 h blood glucose and a 4.2% higher 2 h blood glucose than those in the bottom quartile. We also found an interactive effect between maternal age and CC-Sb on the risk of GDM (p-interaction < 0.001). CONCLUSION: This study suggested significant positive associations of Sb exposure with increased GDM risk and impaired blood glucose homeostasis in pregnant women, and the Sb-GDM association might be modified by maternal age.
Authors: Argyrios Periferakis; Ana Caruntu; Aristodemos-Theodoros Periferakis; Andreea-Elena Scheau; Ioana Anca Badarau; Constantin Caruntu; Cristian Scheau Journal: Int J Environ Res Public Health Date: 2022-04-12 Impact factor: 4.614