| Literature DB >> 31923436 |
Mohammad Aslam Khan1, Haseeb Zubair1, Shashi Anand1, Sanjeev Kumar Srivastava1, Seema Singh2, Ajay Pratap Singh3.
Abstract
Altered cellular metabolism is a hallmark of cancer. Metabolic rewiring in cancer cells occurs due to the activation of oncogenes, inactivation of tumor suppressor genes, and/or other adaptive changes in cell signaling pathways. Furthermore, altered metabolism is also reported in tumor-corrupted stromal cells as a result of their interaction with cancer cells or due to their adaptation in the dynamic tumor microenvironment. Metabolic alterations are associated with dysregulation of metabolic enzymes and tumor-stromal metabolic crosstalk is vital for the progressive malignant journey of the tumor cells. Therefore, several therapies targeting metabolic enzymes have been evaluated and/or are being investigated in preclinical and clinical studies. In this review, we discuss some important metabolic enzymes that are altered in tumor and/or stromal cells, and focus on their role in supporting tumor growth. Moreover, we also discuss studies carried out in various cancers to target these metabolic abnormalities for therapeutic exploitation.Entities:
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Year: 2020 PMID： 31923436 PMCID： PMC7067140 DOI： 10.1016/j.canlet.2020.01.003
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679