Role of Olaparib as Maintenance Treatment for Ovarian Cancer: The Evidence to Date.

PARP inhibitors have shown significant promise in the treatment of ovarian cancer. Olaparib is a PARP inhibitor that has been approved for maintenance for BRCA-mutated ovarian cancer in the recurrent and front-line setting as well as for treatment of BRCA-mutated ovarian cancer in patients who have received multiple prior lines of chemotherapy. In this review, we focus on the use of olaparib in the maintenance setting including the evidence to date, ongoing research, and future directions.

Introduction

Ovarian cancer is the seventh most common cancer in women worldwide and is the leading cause of death from gynecologic cancers in high-income countries.1,2 The five year survival rate in the United States is 48% and the proportion of women dying from their disease has not improved substantially over time as compared to other prevalent cancers.3 Standard treatment for newly diagnosed advanced ovarian cancer consists of cytoreductive surgery and platinum-based chemotherapy with or without concurrent and maintenance bevacizumab, a vascular endothelial growth factor (VEGF) A inhibitor.4 The majority of women with epithelial ovarian cancer respond well to first-line platinum-based chemotherapy however there is a high rate of recurrence with a chemotherapy-free interval before disease progression ranging from 10 to 26 months.5–9 Response to subsequent therapies is variable and often short-lived, underscoring the need for novel effective treatment options to improve long-term disease control for women with ovarian cancer.10,11

Homologous recombination (HR) is a DNA repair process crucial for the accurate repair of DNA damage. BRCA1/2 mutations are known to lead to defective HR and ultimately results in risk for malignant transformation of cells.12 BRCA mutations, both germline and somatic, are thought to occur in up to 25% of patients with newly diagnosed serous ovarian cancer.13 While BRCA1/2 mutations were initially thought to be responsible for the majority of hereditary epithelial ovarian cancers, further investigation has shown that compromise of the HR pathway can occur by several other potential mechanisms.14,15 Thus, it is thought that approximately 50% of high-grade serous ovarian cancers have a deficiency in HR.16

There have been several studies investigating the role of maintenance therapy in ovarian cancer which until recently have not been found to significantly prolong survival.6,17 However, poly (ADP-ribose) polymerase (PARP) inhibitors have shown significant promise with several clinical trials demonstrating a survival improvement in women with newly diagnosed and recurrent ovarian cancer without a substantial increase in adverse effects.18–25 The antitumor effects of PARP inhibitors rely on an exploitation of the defective DNA damage repair in cancer cells with dysfunctional HR. Olaparib is a PARP inhibitor that has several approved indications for use in ovarian cancer and has demonstrated a progression-free survival (PFS) advantage in several trials.19–22

Here, we review the use of olaparib as maintenance treatment for ovarian cancer. We will summarize the evolution of its use, current approved indications, and evidence with respect to its clinical safety and efficacy. Finally, we will provide guidance on treatment decisions with olaparib for patients with ovarian cancer as well as commentary regarding ongoing research and future directions.

Background: Homologous Recombination and PARP Inhibitors

HR is a high-fidelity DNA repair process for double-strand DNA breaks and BRCA1 and BRCA2 are key proteins required for the formation of the repair complex at the site of DNA damage. Germline or somatic mutations in the BRCA1 and BRCA2 genes results in dysfunction of their protein product, which creates genetic instability and thus a predilection of affected cells for malignant transformation. Other genetic aberrations can occur in the HR pathway including mutations in other homologous recombination genes and epigenetic changes such as inactivation of BRCA1/2 or methylation of promoters.14,15

PARP enzymes are involved in detecting single-strand DNA breaks and act as signal transducers via catalytic activity to recruit DNA repair proteins. Ultimately, PARP enzymes are released from the site of single-stranded breaks and repair ensues.26 PARP inhibitors are theorized to work by two potential mechanisms: 1) allowing the persistence of spontaneously occurring single-strand breaks due to a loss of enzymatic function, and 2) preventing the release of PARP from DNA (termed PARP trapping). Both mechanisms lead to persistent single-strand breaks, collapsed replication forks, and resultant double-strand breaks. Repair of double-strand breaks can occur by either homologous recombination or non-homologous end-joining (NHEJ). Homologous recombination repairs DNA with high-fidelity while NHEJ is an error-prone repair process that causes genetic instability.26 In normal cells with intact HR pathways, PARP inhibition is inconsequential given the accurate repair of double-stranded breaks with homologous recombination.

In cells with BRCA1/2 mutations or other abnormalities in HR, PARP inhibition results in a process termed “synthetic lethality” whereby two mechanisms of DNA repair are functionally terminated leading to a reliance on NHEJ and subsequently, cell death.27,28 In this way, PARP inhibitors are unique in that they exploit an underlying defective process in cancer cells. PARP inhibitors are the first Food and Drug Administration (FDA)-approved therapy for ovarian cancer based on the underlying mechanism of malignancy.29 There are currently three PARP inhibitors FDA-approved for use in women with ovarian cancer: olaparib, rucaparib, and niraparib. Their FDA-approved indications are listed in Table 1.30–32

Table 1

PARP Inhibitor FDA Indications for Ovarian Cancer

Drug Name	FDA Indications
Olaparib	Maintenance treatment in germline or somatic BRCA-mutated epithelial ovarian cancer with complete or partial response to first-line platinum-based chemotherapy Maintenance treatment for recurrent epithelial ovarian cancer with complete or partial response to platinum-based chemotherapy Treatment of germline BRCA-mutated advanced ovarian cancer with three or more prior lines of chemotherapy
Rucaparib	Maintenance treatment for recurrent epithelial ovarian cancer with complete or partial response to platinum-based chemotherapy Treatment of germline or somatic BRCA-mutated epithelial ovarian cancer with two or more prior lines of chemotherapy
Niraparib	Maintenance treatment for recurrent epithelial ovarian cancer with complete or partial response to platinum-based chemotherapy Treatment of advanced ovarian cancer treated with three or more prior lines of chemotherapy whose cancer is associated with homologous recombination deficiency positive status

Note: All indications are for epithelial ovarian cancer, fallopian tube, and primary peritoneal cancer.

Background: Olaparib

Olaparib (Lynparza®) is an oral PARP inhibitor developed by AstraZeneca Pharmaceuticals LP. Based on available data, the standard dosing of olaparib is 300 mg tablet twice daily or 400 mg twice daily in capsule form.19–22 The primary adverse events noted in these trials include nausea, fatigue, vomiting, and anemia. A summary of grade 3–4 adverse events is provided in Table 2.19–22 Rare but serious adverse events associated with olaparib use include a risk of developing a secondary malignancy such as myelodysplastic syndrome, acute myeloid leukemia (AML), or chronic myelomonocytic leukemia (CML). Trials have shown that <1.5% of patients using olaparib develop these conditions, with the majority of events having a fatal outcome.22,30 This is roughly equivalent to the rates of AML or CML seen with the use of other PARP inhibitors.23,33 Risk of bone marrow neoplasia has been found to be lower in other oncologic populations after chemotherapy, with one study demonstrating a 10-year cumulative risk of approximately 0.5% among breast cancer patients who received chemotherapy which was significantly different compared to patients who did not receive adjuvant chemotherapy.34

Table 2

Percentage of Patients Experiencing G3-4 Toxicities in Phase III Studies of Olaparib

	Olaparib	Placebo
Anemia	20–22	2
Neutropenia	5–9	4–5
Fatigue	4	2
Nausea/Vomiting	1–6	1
Diarrhea	2–3	0
Thrombocytopenia	1	1–2
Abdominal Pain	0–2	0–1

Olaparib was initially FDA-approved in the United States (US) in 2014 for women with recurrent ovarian cancer who harbored a germline BRCA mutation (gBRCAm) and had received three or more prior lines of chemotherapy (see Figure 1 Timeline of Approval). This approval was based on Study 42 which demonstrated an objective response rate of >30% with olaparib monotherapy in a heavily pretreated patient population.35 Around the same time as the initial FDA-approval for olaparib in 2014, the European Medicines Agency (EMA) approved olaparib as maintenance monotherapy for patients with platinum-sensitive relapsed (PSR) BRCA1/2-mutated high-grade serous epithelial ovarian, fallopian tube, or primary peritoneal cancer, based on Study 19 which will be discussed in detail below.19,20,36 In 2017, the FDA broadened its approval of olaparib to include maintenance monotherapy for patients with platinum-sensitive recurrent ovarian cancer regardless of BRCA mutation status.30 The EMA followed suit shortly thereafter with an approval that matched these indications in 2018.37 And most recently, olaparib was approved for front-line maintenance therapy after a phase III trial (SOLO1) showed significant improvement in PFS among women with germline or somatic BRCA mutations who received olaparib maintenance therapy following platinum-based chemotherapy when compared to placebo (HR 0.30, 95% CI 0.23–0.41).21

Figure 1

Olaparib timeline of approval.

In the remainder of this article, we will review evidence for current approved indications for olaparib as maintenance treatment for ovarian cancer and comment on critical ongoing trials that have the potential to expand its use in this arena.

Olaparib Maintenance Monotherapy for Platinum-Sensitive Recurrent Ovarian Cancer

Following the initial FDA-approval in 2014 for olaparib as monotherapy for recurrent gBRCAm ovarian cancer, several studies sought to demonstrate benefit in the maintenance setting. Study 19 and its subsequent analyses found that olaparib maintenance monotherapy significantly improved PFS in women with platinum-sensitive recurrent ovarian cancer who had received two or more platinum-based regimens and had a complete or partial response demonstrated to the most recent platinum-based chemotherapy, particularly in patients with germline and somatic BRCA mutations.19,20 In this randomized, double-blind, placebo-controlled phase II study, 256 women were enrolled including 129 in the placebo group and 136 in the olaparib group. Patients randomly assigned to the olaparib group received 400 mg twice daily (capsule formulation). Results showed a median PFS advantage of 8.4 months with olaparib versus 4.8 months with placebo (p<0.001). Olaparib was generally well-tolerated, with the most common adverse events reported compared to placebo including nausea (68% versus 35%), fatigue (49% versus 38%), and vomiting (32% versus 14%). Grade 3 and 4 toxicities occurred in 35% of patients who received olaparib versus 20% of patients who received placebo.19

A planned subsequent retrospective analysis of Study 19 was completed in 2014 and sought to explore the hypothesis that women with BRCA mutations would have the greatest benefit with olaparib maintenance treatment. BRCA status was known for approximately 95% of the patients enrolled. Seventy-four patients (56%) in the olaparib group had a known or suspected deleterious or somatic BRCA mutation versus 62 (50%) in the placebo group. For patients with a gBRCAm, PFS was significantly longer for women receiving olaparib compared to placebo (11.2 months vs 4.3 months, p<0.0001). Additionally, there was a statistically significant two month survival advantage in this group (7.4 months versus 5.5 months, p=0.0075).20

SOLO2 was a phase III trial that substantiated the findings of Study 19 and also validated the new tablet formulation of olaparib (versus the capsule formulation used in Study 19). This was a double-blind, randomized, placebo-controlled trial that evaluated olaparib maintenance in platinum-sensitive relapsed ovarian cancer patients with a BRCA1/2 mutation who had received at least two prior lines of chemotherapy. Patients were randomly assigned 2:1 to olaparib 300 mg twice daily or placebo, and randomization was stratified by response to previous platinum chemotherapy (complete versus partial) and length of platinum-free interval (>6–12 months versus >12 months). There were 196 patients randomly assigned to receive olaparib and 99 to receive placebo. The median PFS was significantly longer for women treated with olaparib compared to placebo (19.1 months versus 5.5 months, p<0.0001). Secondary endpoints including time to first subsequent therapy and median time to second progression were significantly improved in the olaparib group when compared to placebo. Additionally, quality of life measures showed no appreciable difference for patients receiving olaparib compared with those receiving placebo. The most common adverse event in the olaparib group was anemia. The rate of serious adverse events was 18% in patients receiving olaparib versus 8% in patients in the placebo group. The PFS benefit seen in SOLO2 substantially exceeded that seen in Study 19 and provided additional data confirming a manageable safety profile of olaparib.22

Olaparib maintenance monotherapy has also been studied after using it in combination with chemotherapy irrespective of BRCA1/2 status. In a phase II trial by Oza et al, women with platinum-sensitive recurrent high-grade serous ovarian cancer who had received up to three previous courses of platinum-based chemotherapy were randomized to receive olaparib in combination with chemotherapy followed by olaparib maintenance monotherapy versus chemotherapy alone. Patients in the combination group (n=81) received paclitaxel (175 mg/m2 on day 1) and carboplatin (AUC 4 mg/mL per min on day 1) plus olaparib (200 mg twice daily on days 1–10 of each 21-day cycle), followed by olaparib monotherapy (400 mg twice daily). Patients in the chemotherapy only group (n=75) received paclitaxel (175 mg/m2 on day 1) and carboplatin (AUC 6 mg/mL per min on day 1) and then no maintenance treatment. The combination chemotherapy and maintenance group had a significantly improved PFS compared to the chemotherapy only group, 12.2 months versus 9.6 months (p=0.0012). However, it is important to note that patients in the combination chemotherapy group had more frequent adverse events during treatment.38 Thus, it is not clear based on these results whether there is any benefit to adding olaparib to cytotoxic chemotherapy prior to olaparib maintenance therapy. Additional investigation would be warranted before this strategy could be recommended as standard of care.

To summarize, these studies demonstrated the efficacy and safety of olaparib as maintenance monotherapy for platinum-sensitive recurrent ovarian cancer irrespective of BRCA mutation status but with a more substantial benefit in patients with BRCA-mutated ovarian cancer (see Table 3 for a summary). Study 19 and SOLO2 were the basis for the 2017 FDA approval for olaparib for platinum-sensitive relapsed ovarian cancer regardless of BRCA mutation status. Given the positive results of these studies and the progression free survival advantage olaparib conferred, new studies sought to evaluate the efficacy of olaparib as maintenance therapy in other settings such as women with newly diagnosed advanced ovarian cancer.

Table 3

Published Trials Evaluating Olaparib Maintenance Therapy

	Study Clinical Trial Phase Year	BRCA Status	Olaparib Use	Design Drug/Dose	Median Progression Free Survival (Olaparib versus Placebo)	Median Overall Survival (Olaparib versus Placebo)
PSR	Study 1919Phase II2012	BRCA mutation not required	Maintenance monotherapy	Randomized, double-blindOlaparib capsule 400 mg orally twice daily	8.4 versus 4.8 months (p< 0.001)	29.7 versus 29.9 months, NS
PSR	Study 19 retrospective interim analysis20 2014	Germline or somatic BRCA1/2 mutation	Maintenance monotherapy	Randomized, double-blind Olaparib capsule 400 mg orally twice daily	BRCAm: 11.2 versus 4.3 months (p< 0.001); BRCAwt: 7.4 versus 5.5 months, (p=0.0075)	Overall: 29.8 versus 27.8 months; BRCAm: 34.9 versus 30.2 months; BRCAwt: 24.5 versus 26.6 months.Did not meet the required threshold for statistical significance of p<0.0095 (71% maturity)
PSR	Oza et al37Phase II2015	BRCA mutation not required	Combination with chemotherapy then maintenance monotherapy	Randomized, open-labelOlaparib capsule 200 mg orally twice daily on days 1–10 of chemotherapy cycle, then olaparib capsule 400 mg orally twice daily	12.2 versus 9.6 months (p< 0.0012)	33.8 versus 37.6 months, NS
PSR	SOLO222Phase III2017	Germline or somatic BRCA1/2 mutation	Maintenance monotherapy	Randomized, double-blindOlaparib tablet 300 mg orally twice daily	19.1 versus 5.5 months (p< 0.0001)	Medians not reached, 23% of patients experienced event versus 27%, NS (24% maturity)
Front-line maintenance	SOLO121Phase III2018	Germline or somatic BRCA1/2 mutation	Maintenance monotherapy	Randomized, double-blindOlaparib tablet 300 mg twice daily	70% lower risk of disease progression or death with olaparib compared to placebo	Rate of freedom from death at 3 years was 84% versus 80%, NS (21% maturity)

Olaparib as First-Line Maintenance Therapy

As olaparib maintenance therapy was found to benefit women in the setting of platinum-sensitive relapsed ovarian cancer, use in the frontline setting was investigated. SOLO1 was a phase III randomized, placebo-controlled, double-blind study that sought to evaluate the efficacy of olaparib as maintenance monotherapy in patients with high-grade serous or endometrioid ovarian cancer, primary peritoneal cancer, or fallopian-tube cancer and a BRCA1/2 mutation (germline or somatic) who had a complete or partial response to platinum-based chemotherapy. Patients were assigned in a 2:1 ratio to receive olaparib tablets 300 mg twice daily or placebo.21

This study demonstrated a substantial PFS benefit with the use of olaparib maintenance therapy. The risk of disease progression or death was 70% lower with olaparib than with placebo after a median follow-up of 41 months (hazard ratio for disease progression or death, 0.28; 95% CI, 0.20 to 0.39; p<0.001). While the median PFS was not yet met for the olaparib group, a sensitivity analysis of investigator-assessed PFS was performed to assess for attrition bias and showed that the median PFS was approximately 36 months longer in the olaparib group compared to the placebo group. Moreover, the median PFS was 13.8 months in the placebo group, which is consistent with other studies of women with BRCA1/2 mutations with newly diagnosed advanced ovarian cancer who received only carboplatin and paclitaxel, thus indicating that the magnitude of PFS benefit is not exaggerated by the poor performance of the placebo group.21 Interim analysis also demonstrated favorable findings for other secondary end points. The median time to first subsequent therapy or death was 51.8 months in the olaparib group and 15.1 months in the placebo group. The estimate of the rate of freedom from the use of second subsequent therapy and from death at three years was 74% in the olaparib group and 56% in the placebo group (hazard ratio for the use of a second subsequent therapy or death, 0.45; 95% CI, 0.32 to 0.63). Measures of health-related quality of life were similar among the olaparib and placebo group. The most common adverse events that occurred during the trial intervention or up to 30 days after discontinuation included nausea, fatigue, vomiting, and anemia. Anemia was the most common serious adverse event, occurring in 7% of patients in the olaparib group compared to no patients in the placebo group.

SOLO1 has provided evidence that PFS advantage can be achieved after frontline therapy particularly in women with BRCA1/2 mutated ovarian cancer. Future research will focus on confirming this benefit and demonstrating efficacy among other populations.

PAOLA-1 (NCT02477644/ENGOT-ov25) is the second phase III trial evaluating the efficacy of olaparib as front-line maintenance therapy and also provides insight regarding concomitant use of olaparib with bevacizumab. Participants received first-line platinum chemotherapy plus bevacizumab and were randomized to maintenance placebo or olaparib plus maintenance bevacizumab regardless of BRCA status. Preliminary results demonstrated a median PFS of 22.1 in the olaparib and bevacizumab group versus 16.6 months in the placebo and bevacizumab group (p<0.0001).39 Of note, sub-analyses showed that the PFS benefit was only demonstrated in those with BRCA mutations or homologous recombination deficiency. Unfortunately no trial arm evaluated olaparib maintenance therapy without bevacizumab, therefore the additional benefit of adding bevacizumab remains unclear.

Ongoing Research and Future Directions

Here we have provided the evidence to date supporting the use of olaparib as first-line maintenance treatment for women with BRCAm ovarian cancer as well as maintenance therapy following treatment for platinum-sensitive recurrent disease. In addition to olaparib, rucaparib and niraparib have FDA and EMA indications for use for maintenance treatment for ovarian cancer.31,32 Studies involving other PARP inhibitors including veliparib and talazoparib have shown promising clinical results and may lead to approvals in the near future (NCT01472783, NCT02470585, NCT01540565, NCT01286987).

The role of olaparib in ovarian cancer continues to expand and there are many questions left to be answered about how to optimize its use. Ongoing studies are evaluating the role of olaparib as maintenance therapy in patients without germline or somatic BRCA mutations, in patients previously treated with a PARP inhibitor, in combination with other targeted therapies, and in the setting of PARP resistance.

BRCA mutations result in homologous recombination deficiency (HRD) and confer sensitivity to PARP inhibition. While only about a quarter of patients with ovarian cancer have germline or somatic BRCA mutations, studies have demonstrated that approximately half have homologous recombination deficient tumors.13–16 This suggests that the population that may derive benefit from olaparib could extend beyond those with BRCA mutations. Data from Study 19 indicate there is likely a benefit, albeit less than for BRCA-mutated patients. This concept is also supported by data from the NOVA trial demonstrating a 9 month improvement in PFS with the use of niraparib as maintenance therapy after treatment for platinum-sensitive recurrent ovarian cancer in non-gBRCA patients with HRD.33 Phase III studies on olaparib maintenance monotherapy in non-BRCAm patients are ongoing (OPINION/NCT03402841).

The advancement of olaparib into front-line maintenance also raises questions regarding the role of subsequent PARP treatment, or the role of PARP after PARP. While trials are ongoing to assess the efficacy of a PARP after prior PARP therapy (OReO, NCT03106987), small retrospective studies have shown that some patients may experience a partial response or stable disease from repeat PARP.40

There is also great interest in the potential benefits of olaparib in combination with other targeted therapies in an effort to overcome PARP resistance and exploit opportunities for additive efficacy. Tumors with BRCA mutations or homologous recombination deficiencies exhibit significantly higher mutational and neoantigen loads and higher PD-L1 expression than BRCA1/2 wild-type or homologous recombination repair intact tumors.41 As such several trials are investigating the role of checkpoint inhibitors in combination with PARP inhibitors. DUO-O (NCT03737643) is an actively-recruiting phase III trial evaluating durvalumab (an anti-PD-L1 antibody) in combination with chemotherapy and bevacizumab followed by maintenance durvalumab, bevacizumab and olaparib. While not a study of olaparib maintenance therapy, MEDIOLA is a phase I/II trial investigating durvalumab in combination with olaparib in a platinum-sensitive BRCAm population (NCT02734004). Emerging clinical data will help establish the efficacy of combination therapy with olaparib and immune check point inhibitors in women with and without BRCA or homologous recombination deficiencies.

The combination of olaparib and anti-angiogenesis therapy is also being explored. It has been theorized that hypoxia leads to downregulation of homologous recombination repair genes.42 As previously discussed, results from PAOLA-1 demonstrated a PFS benefit in women who received olaparib and bevacizumab for frontline maintenance as compared to those who received placebo and bevacizumab. Given that no arm evaluated olaparib maintenance therapy without bevacizumab, its contribution to the PFS benefit is unclear. ICON9 (NCT03278717) is actively recruiting and aims to compare olaparib maintenance treatment with and without cediranib in platinum-sensitive relapsed ovarian cancer. Table 4 lists the active phase III trials utilizing olaparib maintenance therapy.

Table 4

Active Phase III Clinical Trials Utilizing Olaparib as Maintenance Therapy

NCT Number	Trial Name	Phase	Purpose	Status	Sites
NCT03106987	OReO: A Study to Examine Olaparib Maintenance Retreatment in Patients With Epithelial Ovarian Cancer	IIIb	Olaparib maintenance re-treatment in BRCA1/2 + and - patients	Active, recruiting	Belgium, Canada, Denmark, France, Spain, Germany, Israel, Italy, Norway, Poland, Spain, United Kingdom
NCT03278717	ICON9: Study Evaluating the Efficacy of Maintenance Olaparib and Cediranib or Olaparib Alone in Ovarian Cancer Patients	III	Olaparib maintenance treatment ± cediranib in platinum-sensitive relapsed ovarian cancer	Active, recruiting	Australia, United Kingdom
NCT03737643	DUO-O: Durvalumab Treatment in Combination With Chemotherapy and Bevacizumab, Followed by Maintenance Durvalumab, Bevacizumab and Olaparib Treatment in Advanced Ovarian Cancer Patients	III	Durvalumab in combination with standard of care platinum based chemotherapy and bevacizumab followed by maintenance durvalumab and bevacizumab or durvalumab, bevacizumab and olaparib in patients with newly diagnosed advanced ovarian cancer	Active, recruiting	United States (Florida, Georgia, Illinois, Maryland, New York, Ohio, Oklahoma, Pennsylvania, Utah), Austria, Belgium, Bulgaria, Canada, Denmark, Finland, France, Germany, Hungary, Italy, Japan, Korea, Poland, Romania, Spain, Turkey
NCT03740165	MK-7339-001/KEYLYNK-001/ENGOT-ov43: Study of Chemotherapy With Pembrolizumab (MK-3475) Followed by Maintenance With Olaparib (MK-7339) for the First-Line Treatment of Women With BRCA Non-mutated Advanced Epithelial Ovarian Cancer	III	Carboplatin/paclitaxel + pembrolizumab and maintenance olaparib in women with epithelial ovarian cancer, fallopian tube cancer, or primary peritoneal cancer.	Active, recruiting	Belgium, Canada, Chile, Colombia, Czechia, France, Hungary, Israel, Italy, Japan, Korea, Poland, Russian Federation, South Africa, Spain, Taiwan, Turkey, Ukraine
NCT03402841	OPINION: Multicentre Study of Olaparib Maintenance Monotherapy in Platinum Sensitive Relapsed Non gBRCAm Ovarian Cancer Patients	III	Olaparib maintenance in patients with non-BRCAm PSR HGSOC	Active, not recruiting
NCT03534453	L-MOCA: An Open Label, Single Arm, Multicentre Study to Assess the Clinical Efficacy and Safety of Lynparza (Olaparib) Tablets Maintenance Monotherapy in Platinum Sensitive Relapsed Ovarian Cancer Patients Who Are in Complete or Partial Response Following Platinum Based Chemotherapy	III	Olaparib maintenance in patients with PSR high grade epithelial ovarian, fallopian tube, or primary peritoneal cancer	Active, not recruiting
NCT02477644	PAOLA-1: Randomized, Double-Blind, Phase III Trial Olaparib vs Placebo Patients With Advanced FIGO Stage IIIB-IV High Grade Serious or Endometrioid Ovarian, Fallopian Tube, or Peritoneal Cancer Treated Standard First-Line Treatment	III	Olaparib + bevacizumab as front-line maintenance therapy after first-line platinum-based + bevacizumab chemotherapy irrespective of BRCA status	Active, not recruiting

While no phase III trials are directly evaluating the role of PARP inhibitors in platinum-resistant disease, early studies show there may still be a role for PARP treatment in this population. A dose-escalation phase 1b study of alpelisib (a PI3K inhibitor) and olaparib demonstrated that among 28 women with epithelial ovarian cancer, 82% of whom had platinum-resistant disease, 36% had a partial response (median 5.5 months) and 50% had stable disease.43 It should be noted that this was not the primary endpoint of the study. However, these results indicate that the applications of PARP inhibitors, especially in combination with other targeted therapies, may play an important role in an even broader cohort of patients with ovarian cancer. Ongoing Phase II studies including ROLANDO and BAROCCO (NCT03161132, NCT03314740) are investigating the role of combination therapies in platinum-resistant ovarian cancer with olaparib and pegylated liposomal doxorubicin and olaparib, paclitaxel, and cediranib, respecitvely. Future studies could focus on maintenance treatment in this group.

Increased utilization of PARP inhibitors portends a need to better understand PARP inhibitor resistance. The most widely accepted mechanism of PARP inhibitor resistance is the restoration of BRCA function or HR activity via secondary mutations.44 Therefore many strategies for overcoming or preventing PARP inhibitor resistance focus on therapies that downregulate BRCA function or increase the degree of HR deficiencyIt is likely that studies on the horizon will continue to evaluate targeted and combination therapies that increase tumor sensitivity to PARP inhibition. Additionally, efforts to understand characteristics and mechanisms involved in patients with durable responses to olaparib are also underway and will likely provide valuable information (OLALA/NCT02489058).

Conclusion

The advent of PARP inhibitors is an unprecedented advancement in the treatment of women with ovarian cancer. Current FDA approved indications for olaparib use include maintenance for BRCA-mutated ovarian cancer in both the recurrent and front-line setting, as well as for treatment of gBRCAm ovarian cancer in patients who have received multiple prior lines of chemotherapy. With the publication of the results from SOLO1 and SOLO2, the role of olaparib maintenance therapy for women with gBRCAm has been solidified. Importantly, olaparib is the only PARP inhibitor FDA approved for front-line maintenance therapy in BRCA-mutated patients. Ongoing studies will further delineate the role of olaparib in ovarian cancer and likely expand indications for use.