Victoria M Martin1, Yamini V Virkud2, Hannah Seay3, Alanna Hickey3, Renata Ndahayo3, Rachael Rosow3, Caroline Southwick3, Michael Elkort4, Brinda Gupta5, Eileen Kramer5, Tetiana Pronchick5, Susan Reuter5, Corinne Keet6, Kuan-Wen Su7, Wayne G Shreffler2, Qian Yuan8. 1. Food Allergy Center, Massachusetts General Hospital, Boston, Mass; Division of Pediatric Gastroenterology, Hepatology and Nutrition, Massachusetts General Hospital, Boston, Mass; Department of Pediatrics, Harvard Medical School, Boston, Mass; Food Allergy Science Initiative of the Broad Institute, Cambridge, Mass. 2. Food Allergy Center, Massachusetts General Hospital, Boston, Mass; Department of Pediatrics, Harvard Medical School, Boston, Mass; Food Allergy Science Initiative of the Broad Institute, Cambridge, Mass; Division of Pediatric Allergy and Immunology, Massachusetts General Hospital, Boston, Mass. 3. Division of Pediatric Allergy and Immunology, Massachusetts General Hospital, Boston, Mass. 4. Department of Pediatrics, Harvard Medical School, Boston, Mass; Pediatrics at Newton Wellesley, P.C., Newton, Mass. 5. Pediatrics at Newton Wellesley, P.C., Newton, Mass. 6. Division of Pediatric Allergy and Immunology, John's Hopkins Hospital, Baltimore, Md; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Md. 7. Food Allergy Center, Massachusetts General Hospital, Boston, Mass; Department of Pediatrics, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan; Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan. 8. Food Allergy Center, Massachusetts General Hospital, Boston, Mass; Division of Pediatric Gastroenterology, Hepatology and Nutrition, Massachusetts General Hospital, Boston, Mass; Department of Pediatrics, Harvard Medical School, Boston, Mass; Food Allergy Science Initiative of the Broad Institute, Cambridge, Mass; Pediatrics at Newton Wellesley, P.C., Newton, Mass. Electronic address: qyuan@mgh.harvard.edu.
Abstract
BACKGROUND: Food protein-induced allergic proctocolitis (FPIAP) is an early and common manifestation of food allergy, yet its epidemiology and relationship to other allergic diseases remain unclear. OBJECTIVE: To prospectively define the incidence of FPIAP as it is being diagnosed clinically in the community and to identify factors associated with its development. METHODS: A total of 1003 of 1162 eligible serial healthy newborn infants recruited from a single suburban pediatrics practice were followed prospectively for the diagnosis of FPIAP. Investigators reviewed each case to confirm prespecified inclusion criteria, including documented gross or occult blood in the stool. RESULTS: A total of 903 infants were analyzed (46% females, 89% term, 32% caesarian-section, 9% neonatal antibiotics); 153 cases met inclusion criteria, a cumulative incidence of 17%, while 63 (7%) had gross blood. Infants initially fed both breast milk and formula were 61% less likely to develop FPIAP compared with those exclusively formula-fed (hazard ratio, 0.39; P = .005). Breast milk and formula at any point during the first 4 months were also associated with lower risk compared with exclusive formula or exclusive breast milk (hazard ratio, 0.44; P = .005; hazard ratio, 0.62; P = .0497). Eczema (odds ratio, 1.5; 95% confidence interval, 1.1- 2.2; P = .02) or a first-degree relative with food allergies (odds ratio, 1.9; 95% confidence interval, 1.2-2.8; P = .005) were among risk factors for FPIAP development. CONCLUSIONS: The prospectively defined incidence of FPIAP when diagnosed clinically by community pediatricians without challenge is markedly higher than published estimates. Combination feeding of formula and breast milk is associated with the lowest rate of FPIAP in this population.
BACKGROUND: Food protein-induced allergic proctocolitis (FPIAP) is an early and common manifestation of food allergy, yet its epidemiology and relationship to other allergic diseases remain unclear. OBJECTIVE: To prospectively define the incidence of FPIAP as it is being diagnosed clinically in the community and to identify factors associated with its development. METHODS: A total of 1003 of 1162 eligible serial healthy newborn infants recruited from a single suburban pediatrics practice were followed prospectively for the diagnosis of FPIAP. Investigators reviewed each case to confirm prespecified inclusion criteria, including documented gross or occult blood in the stool. RESULTS: A total of 903 infants were analyzed (46% females, 89% term, 32% caesarian-section, 9% neonatal antibiotics); 153 cases met inclusion criteria, a cumulative incidence of 17%, while 63 (7%) had gross blood. Infants initially fed both breast milk and formula were 61% less likely to develop FPIAP compared with those exclusively formula-fed (hazard ratio, 0.39; P = .005). Breast milk and formula at any point during the first 4 months were also associated with lower risk compared with exclusive formula or exclusive breast milk (hazard ratio, 0.44; P = .005; hazard ratio, 0.62; P = .0497). Eczema (odds ratio, 1.5; 95% confidence interval, 1.1- 2.2; P = .02) or a first-degree relative with food allergies (odds ratio, 1.9; 95% confidence interval, 1.2-2.8; P = .005) were among risk factors for FPIAP development. CONCLUSIONS: The prospectively defined incidence of FPIAP when diagnosed clinically by community pediatricians without challenge is markedly higher than published estimates. Combination feeding of formula and breast milk is associated with the lowest rate of FPIAP in this population.
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