Vivek Shukla1, Omar Elkhateeb1, Prakesh S Shah2,3,4, Junmin Yang4, Kyong-Soon Lee5,6. 1. Division of Neonatology, Department of Pediatrics, The Hospital for Sick Children, Room 38102, 555 University Avenue, Toronto, ON, M5G 1X8, Canada. 2. Department of Pediatrics, Mount Sinai Hospital, Toronto, ON, Canada. 3. Department of Pediatrics, University of Toronto, Toronto, ON, Canada. 4. Maternal-Infant Care Research Centre, Mount Sinai Hospital, Toronto, ON, Canada. 5. Division of Neonatology, Department of Pediatrics, The Hospital for Sick Children, Room 38102, 555 University Avenue, Toronto, ON, M5G 1X8, Canada. kyong-soon.lee@sickkids.ca. 6. Department of Pediatrics, University of Toronto, Toronto, ON, Canada. kyong-soon.lee@sickkids.ca.
Abstract
OBJECTIVE: To evaluate outcomes of preterm infants <26 weeks gestational age (GA) following postdelivery extensive cardiopulmonary resuscitation (ECPR) compared with airway and breathing support (ABS). STUDY DESIGN: Retrospective review of Canadian Neonatal Network data during January 2010 to December 2016. The primary outcome was death or severe morbidity (intraventricular hemorrhage ≥grade 3 or periventricular leucomalacia, retinopathy of prematurity ≥stage 3, bronchopulmonary dysplasia, or necrotizing enterocolitis). RESULT: Among 3633 infants analyzed, 433 (11.9%) received ECPR. In multivariable analysis, death or severe morbidity was higher in the ECPR versus ABS group [adjusted odds ratio 2.26 (95% confidence interval 1.49, 3.43)]. The majority of the difference was due to increased mortality, which occurred mostly during the first week of life. CONCLUSION: These data from a recent cohort of infants near the limits of viability may be useful for prognostication for health care providers and counseling of parents.
OBJECTIVE: To evaluate outcomes of preterm infants <26 weeks gestational age (GA) following postdelivery extensive cardiopulmonary resuscitation (ECPR) compared with airway and breathing support (ABS). STUDY DESIGN: Retrospective review of Canadian Neonatal Network data during January 2010 to December 2016. The primary outcome was death or severe morbidity (intraventricular hemorrhage ≥grade 3 or periventricular leucomalacia, retinopathy of prematurity ≥stage 3, bronchopulmonary dysplasia, or necrotizing enterocolitis). RESULT: Among 3633 infants analyzed, 433 (11.9%) received ECPR. In multivariable analysis, death or severe morbidity was higher in the ECPR versus ABS group [adjusted odds ratio 2.26 (95% confidence interval 1.49, 3.43)]. The majority of the difference was due to increased mortality, which occurred mostly during the first week of life. CONCLUSION: These data from a recent cohort of infants near the limits of viability may be useful for prognostication for health care providers and counseling of parents.
Authors: Myra H Wyckoff; Walid A Salhab; Roy J Heyne; Douglas E Kendrick; Barbara J Stoll; Abbot R Laptook Journal: J Pediatr Date: 2011-09-17 Impact factor: 4.406
Authors: Matthew A Rysavy; Lei Li; Edward F Bell; Abhik Das; Susan R Hintz; Barbara J Stoll; Betty R Vohr; Waldemar A Carlo; Seetha Shankaran; Michele C Walsh; Jon E Tyson; C Michael Cotten; P Brian Smith; Jeffrey C Murray; Tarah T Colaizy; Jane E Brumbaugh; Rosemary D Higgins Journal: N Engl J Med Date: 2015-05-07 Impact factor: 91.245