Literature DB >> 31909603

Quantitative Systems Toxicology Modeling To Address Key Safety Questions in Drug Development: A Focus of the TransQST Consortium.

Sofia Ferreira1, Ciarán Fisher1, Laura I Furlong2, Loic Laplanche3, Brian Kevin Park4, Carmen Pin5, Julio Saez-Rodriguez6, Panuwat Trairatphisan3,6.   

Abstract

Omics data have been increasingly generated with limited demonstrated value in drug safety assessment. The TransQST consortium was launched to use omics and other data in mechanistic-based quantitative systems toxicology (QST) models to evaluate their potential use in species translation.

Mesh：

Year:  2020        PMID： 31909603     DOI： 10.1021/acs.chemrestox.9b00499

Source DB:  PubMed          Journal:  Chem Res Toxicol        ISSN： 0893-228X            Impact factor:   3.739


  6 in total

1.  Development of In Silico Methods for Toxicity Prediction in Collaboration Between Academia and the Pharmaceutical Industry.

Authors:  Manuel Pastor; Ferran Sanz; Frank Bringezu
Journal:  Methods Mol Biol       Date:  2022

Review 2.  Systems Modeling to Quantify Safety Risks in Early Drug Development: Using Bifurcation Analysis and Agent-Based Modeling as Examples.

Authors:  Carmen Pin; Teresa Collins; Megan Gibbs; Holly Kimko
Journal:  AAPS J       Date:  2021-05-20       Impact factor: 4.009

3.  Solving the Evidence Interpretability Crisis in Health Technology Assessment: A Role for Mechanistic Models?

Authors:  Eulalie Courcelles; Jean-Pierre Boissel; Jacques Massol; Ingrid Klingmann; Riad Kahoul; Marc Hommel; Emmanuel Pham; Alexander Kulesza
Journal:  Front Med Technol       Date:  2022-02-24

4.  A Transcriptomic Approach to Elucidate the Mechanisms of Gefitinib-Induced Toxicity in Healthy Human Intestinal Organoids.

Authors:  Daniela Rodrigues; Bram Herpers; Sofia Ferreira; Heeseung Jo; Ciarán Fisher; Luke Coyle; Seung-Wook Chung; Jos C S Kleinjans; Danyel G J Jennen; Theo M de Kok
Journal:  Int J Mol Sci       Date:  2022-02-17       Impact factor: 5.923

Review 5.  Two heads are better than one: current landscape of integrating QSP and machine learning : An ISoP QSP SIG white paper by the working group on the integration of quantitative systems pharmacology and machine learning.

Authors:  Tongli Zhang; Ioannis P Androulakis; Peter Bonate; Limei Cheng; Tomáš Helikar; Jaimit Parikh; Christopher Rackauckas; Kalyanasundaram Subramanian; Carolyn R Cho
Journal:  J Pharmacokinet Pharmacodyn       Date:  2022-02-01       Impact factor: 2.745

6.  New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids.

Authors:  Daniela Rodrigues; Terezinha de Souza; Luke Coyle; Matteo Di Piazza; Bram Herpers; Sofia Ferreira; Mian Zhang; Johanna Vappiani; Daniel C Sévin; Attila Gabor; Anthony Lynch; Seung-Wook Chung; Julio Saez-Rodriguez; Danyel G J Jennen; Jos C S Kleinjans; Theo M de Kok
Journal:  Arch Toxicol       Date:  2021-06-20       Impact factor: 5.153
  6 in total

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