Literature DB >> 3190687

Phosphatidylethanol formation in human platelets: evidence for thrombin-induced activation of phospholipase D.

R Rubin1.   

Abstract

Phosphatidylethanol formation was examined in (3H)arachidonic acid-labeled human platelets. In the presence of ethanol, thrombin induced the formation of (3H)phosphatidylethanol in a time- and concentration-dependent manner. The appearance of phosphatidylethanol did not involve de novo synthesis since no 32P radioactivity was incorporated into phosphatidylethanol in 32P-labeled platelets or in platelets that were permeabilized with saponin in the presence of 32P-ATP. The data provide evidence for the direct activation by thrombin of phospholipase D in human platelets.

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Year:  1988        PMID： 3190687     DOI： 10.1016/s0006-291x(88)80744-7

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  20 in total

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Authors:  M M Billah; J C Anthes
Journal:  Biochem J       Date:  1990-07-15       Impact factor: 3.857

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Authors:  R W Bonser; N T Thompson; R W Randall; L G Garland
Journal:  Biochem J       Date:  1989-12-01       Impact factor: 3.857

3.  Platelet phospholipase D is activated by protein kinase C via an integrin alpha IIb beta 3-independent mechanism.

Authors:  E A Martinson; S Scheible; A Greinacher; P Presek
Journal:  Biochem J       Date:  1995-09-01       Impact factor: 3.857

4.  Stimulation of phospholipase D in rabbit platelet membranes by nucleoside triphosphates and by phosphocreatine: roles of membrane-bound GDP, nucleoside diphosphate kinase and creatine kinase.

Authors:  X T Fan; J L Sherwood; R J Haslam
Journal:  Biochem J       Date:  1994-05-01       Impact factor: 3.857

5.  Activation and solubilization by Triton X-100 of membrane-bound phospholipase D of rat brain.

Authors:  H Kanoh; Y Kanaho; Y Nozawa
Journal:  Lipids       Date:  1991-06       Impact factor: 1.880

6.  Guanine-nucleotide- and adenine-nucleotide-dependent regulation of phospholipase D in electropermeabilized HL-60 granulocytes.

Authors:  M S Xie; G R Dubyak
Journal:  Biochem J       Date:  1991-08-15       Impact factor: 3.857

7.  The relationship between cytosolic Ca2+, sn-1,2-diacylglycerol and inositol 1,4,5-trisphosphate elevation in platelet-activating-factor-stimulated rabbit platelets. Influence of protein kinase C on production of signal molecules.

Authors:  C T Murphy; M Elmore; S Kellie; J Westwick
Journal:  Biochem J       Date:  1991-08-15       Impact factor: 3.857

8.  Evidence for coupling of Clostridium perfringens alpha-toxin-induced hemolysis to stimulated phosphatidic acid formation in rabbit erythrocytes.

Authors:  J Sakurai; S Ochi; H Tanaka
Journal:  Infect Immun       Date:  1993-09       Impact factor: 3.441

9.  Vasopressin stimulates phospholipase D activity against phosphatidylcholine in vascular smooth muscle cells.

Authors:  C J Welsh; K Schmeichel; H T Cao; H Chabbott
Journal:  Lipids       Date:  1990-11       Impact factor: 1.880

10.  Activation of signal transduction in platelets by the tyrosine phosphatase inhibitor pervanadate (vanadyl hydroperoxide).

Authors:  K M Pumiglia; L F Lau; C K Huang; S Burroughs; M B Feinstein
Journal:  Biochem J       Date:  1992-09-01       Impact factor: 3.857
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