Literature DB >> 2557846

Phospholipase D activation is functionally linked to superoxide generation in the human neutrophil.

R W Bonser1, N T Thompson, R W Randall, L G Garland.   

Abstract

Neutrophils stimulated with formylmethionyl-leucylphenylalanine (fMet-Leu-Phe) in the presence of butanol and ethanol formed phosphatidyl alcohols through a phospholipase D mechanism. The alcohols inhibited phosphatidic acid and diradylglycerol (DRG) formation, but did not block inositol 1, 4, 5-trisphosphate release. fMet-Leu-Phe-stimulated superoxide production was inhibited by alcohol concentrations which blocked DRG formation, whereas opsonized-zymosan-stimulated superoxide production was only partially decreased. These results suggest that phospholipase D activation is functionally linked to superoxide production in the human neutrophil.

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Year:  1989        PMID： 2557846      PMCID： PMC1133625          DOI： 10.1042/bj2640617

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  32 in total

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Authors:  E G BLIGH; W J DYER
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Review 2.  Receptor regulation of choline phospholipid hydrolysis. A novel source of diacylglycerol and phosphatidic acid.

Authors:  K Löffelholz
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3.  Phosphatidylethanol biosynthesis in ethanol-exposed NG108-15 neuroblastoma X glioma hybrid cells. Evidence for activation of a phospholipase D phosphatidyl transferase activity by protein kinase C.

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Journal:  J Biol Chem       Date:  1989-01-25       Impact factor: 5.157

4.  Interleukin-1 generates transmembrane signals from phospholipids through novel pathways in cultured rat mesangial cells.

Authors:  M Kester; M S Simonson; P Mené; J R Sedor
Journal:  J Clin Invest       Date:  1989-02       Impact factor: 14.808

5.  Superoxide generation by digitonin-stimulated guinea pig granulocytes. A basis for a continuous assay for monitoring superoxide production and for the study of the activation of the generating system.

Authors:  H J Cohen; M E Chovaniec
Journal:  J Clin Invest       Date:  1978-04       Impact factor: 14.808

6.  Chemoattractant receptor functions in human polymorphonuclear leukocytes are divergently altered by membrane fluidizers.

Authors:  I Yuli; A Tomonaga; R Synderman
Journal:  Proc Natl Acad Sci U S A       Date:  1982-10       Impact factor: 11.205

7.  Diacylglycerol generation and phosphoinositide turnover in human neutrophils: effects of particulate versus soluble stimuli.

Authors:  D N Burnham; S R Tyagi; D J Uhlinger; J D Lambeth
Journal:  Arch Biochem Biophys       Date:  1989-02-15       Impact factor: 4.013

8.  Interleukin-3-stimulated haemopoietic stem cell proliferation. Evidence for activation of protein kinase C and Na+/H+ exchange without inositol lipid hydrolysis.

Authors:  A D Whetton; S J Vallance; P N Monk; E J Cragoe; T M Dexter; C M Heyworth
Journal:  Biochem J       Date:  1988-12-01       Impact factor: 3.857

9.  Stimulation of phosphorylcholine turnover and diacylglycerol production in human polymorphonuclear leukocytes. Novel assay for phosphorylcholine.

Authors:  A P Truett; R Snyderman; J J Murray
Journal:  Biochem J       Date:  1989-06-15       Impact factor: 3.857

10.  Development of a novel, Ins(1,4,5)P3-specific binding assay. Its use to determine the intracellular concentration of Ins(1,4,5)P3 in unstimulated and vasopressin-stimulated rat hepatocytes.

Authors:  S Palmer; K T Hughes; D Y Lee; M J Wakelam
Journal:  Cell Signal       Date:  1989       Impact factor: 4.315
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  29 in total

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Authors:  N Shibata; A Hirano; M Kobayashi; T Umahara; T Kawanami; K Asayama
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Review 2.  Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance.

Authors:  John T Williams; Susan L Ingram; Graeme Henderson; Charles Chavkin; Mark von Zastrow; Stefan Schulz; Thomas Koch; Christopher J Evans; Macdonald J Christie
Journal:  Pharmacol Rev       Date:  2013-01-15       Impact factor: 25.468

3.  Inhibition of phospholipase D blocks activation of fibrinogen-adherent neutrophils by tumor necrosis factor.

Authors:  M O Frank; G W Sullivan; H T Carper; G L Mandell
Journal:  Infect Immun       Date:  1994-06       Impact factor: 3.441

4.  Evidence for a nucleotide receptor on adrenal medullary endothelial cells linked to phospholipase C and phospholipase D.

Authors:  J R Purkiss; G F Wilkinson; M R Boarder
Journal:  Br J Pharmacol       Date:  1993-04       Impact factor: 8.739

5.  Guanine-nucleotide- and adenine-nucleotide-dependent regulation of phospholipase D in electropermeabilized HL-60 granulocytes.

Authors:  M S Xie; G R Dubyak
Journal:  Biochem J       Date:  1991-08-15       Impact factor: 3.857

6.  Protein kinase C activity is not involved in N-formylmethionyl-leucyl-phenylalanine-induced phospholipase D activation in human neutrophils, but is essential for concomitant NADPH oxidase activation: studies with a staurosporine analogue with improved selectivity for protein kinase C.

Authors:  G C Kessels; K H Krause; A J Verhoeven
Journal:  Biochem J       Date:  1993-06-15       Impact factor: 3.857

7.  Guanosine 5'-[gamma-thio]triphosphate induces membrane localization of cytosol-independent phospholipase D activity in a cell-free system from U937 promonocytic leucocytes.

Authors:  D J Kusner; G R Dubyak
Journal:  Biochem J       Date:  1994-12-01       Impact factor: 3.857

8.  Correlation between secretion and phospholipase D activation in differentiated HL60 cells.

Authors:  J Stutchfield; S Cockcroft
Journal:  Biochem J       Date:  1993-08-01       Impact factor: 3.857

9.  Tyrosine phosphorylation is involved in receptor coupling to phospholipase D but not phospholipase C in the human neutrophil.

Authors:  I J Uings; N T Thompson; R W Randall; G D Spacey; R W Bonser; A T Hudson; L G Garland
Journal:  Biochem J       Date:  1992-02-01       Impact factor: 3.857

10.  Early signalling events implicated in leukotriene B4-induced activation of the NADPH oxidase in eosinophils: role of Ca2+, protein kinase C and phospholipases C and D.

Authors:  R S Perkins; M A Lindsay; P J Barnes; M A Giembycz
Journal:  Biochem J       Date:  1995-09-15       Impact factor: 3.857
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