Does Combined Anterior-Posterior Approach Improve Outcomes Compared with Posterioronly Approach in Traumatic Thoracolumbar Burst Fractures?: A Systematic Review.

The aim of this systematic review was to evaluate the surgical, radiological, and functional outcomes of posterior-only versus combined anterior-posterior approaches in patients with traumatic thoracolumbar burst fractures. The ideal approach (anterior-only, posterior-only, or combined anterior-posterior) for the surgical management of thoracolumbar burst fracture remains controversial, with each approach having its advantages and disadvantages. A systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines was performed (registration no., CRD42018115120). The authors reviewed comparative studies evaluating posterior-only approach compared with combined anterior-posterior approaches with respect to clinical, surgical, radiographic, and functional outcome measures. Five retrospective cohort studies were included. Postoperative neurological deterioration was not reported in either group. Operative time, estimated blood loss, and postoperative length of stay were increased among patients in the combined anterior-posterior group in one study and equivalent between groups in another study. No significant difference was observed between the two approaches with regards to long-term postoperative Cobb angle (mean difference, -0.2; 95% confidence interval, -5.2 to 4.8; p =0.936). Moreover, no significant difference in functional patient outcomes was observed in the 36item Short-Form Health Survey, Visual Analog Scale, and return-to-work rates between the two groups. The available evidence does not indicate improved clinical, radiologic (including kyphotic deformity), and functional outcomes in the combined anterior-posterior and posterior-only approaches in the management of traumatic thoracolumbar burst fractures. Further studies are required to ascertain if a subset of patients will benefit from a combined anterior-posterior approach.

Introduction

Burst fractures involve the superior and/or inferior vertebral body endplate and extend into the posterior cortex. Fracture fragments may be retropulsed into the spinal canal, potentially causing canal stenosis and neurological compromise. Although significantly associated posterior osteoligamentous distraction and rotational or translational injury require surgical intervention [1], the management of thoracolumbar burst-only fractures remains unclear, particularly in neurologically intact patients or in those with isolated radiculopathy.

Among fractures requiring surgical intervention, a debate on which among the anterior, posterior, and combined anterior-posterior approaches provide the best outcomes remains. Historically, anterior-only approaches have been found to induce superior decompression due to its ability to directly remove fracture fragments. However, ongoing improvement on the stability of pedicle screw and the ability to place them quickly and safely has prompted some to use posterior fixation as a standalone procedure or as a supplementation of an anterior construct, particularly in fractures with associated kyphosis.

This systematic review aims to compare the surgical, radiological, and functional outcomes of a combined anterior-posterior approach with those of a posterior-only approach in the surgical fixation of traumatic thoracolumbar burst fractures in adult patients requiring surgical intervention.

Materials and Methods

This systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement [2]. A study protocol was prospectively registered on the PROSPERO database (registration no., CRD42018115120).

1. Eligibility criteria

We included all studies comparing (prospectively or retrospectively) a combined anterior-posterior with a posterior-only approach for the management of a traumatic burst fracture located between T10 and L2, in which at least one of the following outcomes at 6-month follow-up was reported: neurological function (e.g., Frankel grading), kyphotic deformity (measured using the Cobb angle), postoperative complications, construct failure (any instrumentation fracture/breakage, implant loosening, or pullout), length of hospital stay, estimated blood loss, pre- and postoperative pain and functional scores (including Visual Analog Scale [VAS], Oswestry Disability Index [ODI], Roland-Morris Disability Questionnaire [RMDQ]), and ability to return to work.

We excluded studies that (1) focused on pathologic or osteoporotic, rather than traumatic, etiologies and (2) included nonburst morphologies (i.e., isolated endplate fractures, distraction injuries, translational injuries, rotational injuries, posterior osteoligamentous complex injuries, and AO type A1, A2, B, and C fractures). Studies assessing a heterogeneous sample of fracture types were eligible for inclusion provided disaggregated data were available for analysis of the burst fracture subgroup. Studies were not excluded based on the presence or absence of neurological compromise among the included sample.

2. Information sources

The MEDLINE/PubMed, Web of Science, EMBASE, Google Scholar, and Cochrane databases were searched from inception to December 30, 2018. In the MEDLINE/ PubMed database, Boolean operators were used to combine the following MeSH items in the MEDLINE/PubMed database: “Spinal Fractures,” “Spinal Cord Injury,” “Thoracic Vertebrae,” “Lumbar Vertebrae,” and “Fracture Fixation.” This was supplemented by using a combination of the following “key words/topics” in the Web of Science, EMBASE, Google Scholar, and Cochrane databases: “Burst,” “Burst Fracture,” “Thoracolumbar,” “A3,” “A4,” “Surgery,” “Anterior,” “Posterior,” “Combined anteroposterior,” and “Combined anterior-posterior.”

3. Study selection and data extraction

Two authors (T.T. and J.T.) screened all articles independently and in duplicate for inclusion in this study, with contested citations referred to an independent author if necessary. Database searches were accompanied with manually searching the bibliographies of included studies to identify relevant articles.

Data from included studies were entered onto a preformatted data collection form by a single author (T.T.) and then independently verified by another author (J.T.). Extracted data included the journal and year of publication, number of authors, population demographics, operative details (description of procedure, type of decompression, type of instrumentation, duration of surgery, and estimated blood loss), and radiological (the Cobb angle at the final follow-up and change in the Cobb angle, i.e., the final Cobb angle at the follow-up and the preoperative Cobb angle), clinical (neurological function, mortality, and morbidity), and functional outcomes (e.g., VAS, ODI, and RMDQ). Surgical complication and construct failure rates were also extracted. We extracted the rationale for choosing a particular approach but did not control preoperative clinical/radiological variables for each study group.

4. Assessment of reporting quality

The methodological quality and risk of bias were assessed independently and in duplicate by two authors (T.T. and J.T.). Randomized studies received a score of “yes,” “no,” or “unclear” for each item described in the Cochrane assessment tool [3], whereas nonrandomized studies were evaluated using the Newcastle-Ottawa Quality Assessment Scale [4]. Discrepancies were resolved by discussion between the two authors (J.T. and T.T.).

5. Statistical analysis

Due to the lack of controlled trials and high-quality retrospective studies, the reported results are mainly based on a qualitative synthesis of the available data. Where >2 studies reported quantitative data on the outcome variable of interest, the data were combined and summarized using mean differences (MDs) for continuous outcomes. Effect size and 95% confidence interval (CI) are presented using forest plots. Meta-analysis was performed using Open-MetaAnalyst (Brown University, Providence, RI, USA). A p-value of <0.05 was considered statistically significant.

Results

1. Literature search

The systematic literature search yielded 4,015 initial studies whose titles and abstracts were screened. Of these, 40 articles were eligible for full-text review, out of which five studies were suitable for inclusion in this review [5-9]. Fig. 1 shows the initial literature search results and subsequent exclusion/inclusion of studies.

Fig. 1.

Preferred Reporting Items for Systematic Reviews and Meta-Analyses flow diagram.

2. Study characteristics

All five included articles had a retrospective cohort design (level III evidence). The number of subjects in the included studies ranged from 20 to 46 (median, 35). The duration of follow-up ranged from 3 to 69 months (median, 27 months). One study investigated neurologically intact patients only [8], whereas two studies included neurologically intact and nonintact patients [5,7], and neurological status was not stated in two studies [6,9]. Table 1 summarizes patient demographics, fracture characteristics (including classification), and rationale of the approach of included studies.

Table 1.

Patient demographics and fracture classification

Variable	Author (year)
	Been and Bouma [5] (1999)	Briem et al. [6] (2004)	Danisa et al. [7] (1995)	Mayer et al. [8] (2017)	Schmid et al. [9] (2012)
Study design	Retrospective Cohort	Retrospective Cohort	Retrospective Cohort	Retrospective Cohort	Retrospective Cohort
Total no. of patients	46	20	33	36	35
No. of each group	AP, 27; post, 19	AP, 10; post, 10	AP, 6; post, 27	AP, 14; post, 22	AP, 14; post, 21
Age (yr)	AP, 26.8±8.6; post, 33.7±13.1	AP, 63.00±49.6; post, 59.0±48.2	AP, 36.8 (13–63); post, 37.7 (19–75)	AP, 34±10.6; post, 42.0±14	AP, 39.3±13.5; post, 32.7±11.3
Gender (% female)	AP, 44.4%; post, 42.1%	AP, 60.0%; post, 60.0%	AP, 33.3%; post, 29.6%	AP, 28.6%; post, 50.0%	AP, 23.81%; post, 42.86%
Fr acture classification and typing (no. of patients)	Denis burst fractures only: Denis type A (12/46); Denis type B (20/46); Denis type C (0/46); Denis type D (14/46); Denis type E (0/46)	Magerl type 3 fractures only: Magerl 3.1 (13/20); Magerl 3.2 (5/20); Magerl 3.3 (2/20)	Denis burst fractures only: Denis type A (21/33); Denis type B (10/33); Denis type C (2/33)	Magerl type 3 fractures only: (36/36)	Magerl type 3 fractures only: (35/35)
Neurological status	Intact and non-intact	Intact only	Intact and non-intact	Intact only	Intact only
Ra tionale for approach	The choice for either type of surgical approach was not randomized, but was decided by the surgeon based on availability of instrumentation and the presence of severe other organ injuries.	Not reported	The surgical procedure performed were determined by each individual’s attending physician.	The decision of treatment was according to the attending surgeons’ discretion.	The patients were treated according to the surgeon’s preferences in a single university-based trauma center.

Values are presented as number, mean±standard deviation, or mean (range).

AP, anterior-posterior; post, posterior.

3. Qualitative analysis

1) Description of the approach and operative technique

Table 2 presents the combined anterior-posterior and posterior-only approaches with regards to method of fixation, fusion, and decompression. Generally, there was considerable variability in operative technique.

Table 2.

Summary of operative fixation, fusion, and decompression techniques

Author (year)		Positioning/approach	Decompression	Fixation	Supplemental fusion
Combined anterior-posterior approach
	Been and Bouma [5] (1999)	NR	Direct canal decompression with subtotal corpectomy	Single rod slot-Zielke system; pedicle screws and rods or Cottrel-Dubosset compression rod system	Anterior: ICBG anterior strut
	Briem et al. [6] (2004)	NR	NR	Pedicle screw and rod system (Depuy USS Fracture System); anterolateral screwplate system (Aesculap MACS)	Anterior: ICBG anterior strut
	Danisa et al. [7] (1995)	Right lateral decubitus, prone	Direct canal decompression with subtotal corpectomy	Kaneda device (n=1); Harrington rods and hooks (n=1); Cotrel-Doubousset rods and hooks (n=1); Luque rings and sublaminar wiring (n=2); Texas Scottish Rite Hospital rods and hooks (n=2)	Anterior: fibular strut graft or morselized rib graft; posterior: ICBG or human freeze-dried bone graft
	Mayer et al. [8] (2017)	Right lateral decubitus, prone	Partial corpectomy but dura not directly decompressed	Anterior: MACS plate/screw system; posterior: Bisegmental pedicle screws; one level up one down sparing fracture level	Autologous bone graft or distractable vertebral body cage
	Schmid et al. [9] (2012)	Right lateral decubitus	Thoracoscopic direct decompression	Pedicle screw (Depuy USS one level above and one below fracture level)	Anterior: tricortical strut graft or titanium adjustablecage
Posterior approach
	Been and Bouma [5] (1999)	Prone	Indirect decompression only	AO internal fixator	NR
	Briem et al. [6] (2004)	Prone	NR	Pedicle screw and rod system (Depuy USS Fracture System)	NR
	Danisa et al. [7] (1995)	Prone	Posterolateral transpedicular approach (n=12); indirect decompression with ligamentotaxis of posterior longitudinal ligament (n=15)	Steffee plates and pedicle screws (n=16); Cotrel-Doubousset rods with hook and claw system (n=4); Harrington distraction rods and hooks (n=4); Luque rings with sublaminar wiring (n=3)	IBGB or human freeze dried bone
	Mayer et al. [8] (2017)	Prone	Indirect decompression only	Bisegmental pedicle screw fixation	NR
	Schmid et al. [9] (2012)	Prone	Direct decompression via TLIF approach	Pedicle screws (USS Depuy one level above and one below fracture level)	Posterolateral fusion: unilateral TLIF with monocortical strut grafts and ICBG

NR, not recorded; ICBG, iliac crest bone graft; MACS, modular anterior construct system; TLIF, transforaminal lumbar interbody fusion.

When stated, anterior approaches were performed with the patient in the right lateral decubitus position. Decompression from an anterior approach was frequently with the direct decompression of the visualized thecal sac [5,7,9]. Anterior column reconstruction was achieved with anterolateral screw-plate systems and/or vertebral body grafts, such as strut grafts or corpectomy cages.

In posterior approaches, decompression was obtained through a direct fashion [7,9] or indirectly via ligamentotaxis/annulotaxis [5,8]. Posterior fixation was predominantly achieved with a pedicle screw and rod fixation.

2) Neurological outcome

Using Frankel grades, two studies that included neurologically intact and nonintact patients (Frankel A–E) reported pre- and postoperative neurological outcomes [5,7]. Postoperative neurological deterioration was not noted. In the study by Been and Bouma [5], except one patient in the posterior-only group, all neurologically compromised (Frankel A–D) patients in both surgical cohorts experienced an improvement of at least one Frankel grade during the follow-up. Danisa et al. [7] demonstrated similar results, with two of three neurologically compromised patients in the combined anterior-posterior cohort and eight of 11 in the posterior-only group, improving by one or more Frankel grades postoperatively.

3) Operative variables and length of hospital stay

Two studies reported the length of hospital stay, total duration of surgery, and estimated blood loss [7,9]. Danisa et al. [7] reported a postoperative length of stay of 13±4.5 days for the posterior-only group and 22±7.0 days for the combined anterior-posterior group. The duration of surgery was 219±61 minutes (posterior-only group) compared with 569±121 minutes (anterior-posterior group). Estimated blood loss was 1,103±793 mL (posterior-only group) compared with 2,541±1,439 mL (anterior-posterior group). Thus, the combined anterior-posterior approaches were associated with a significant increase in the total operative time, estimated blood loss, and postoperative length of hospital stay (p<0.05).

Schmid et al. [9] found no statistical significant differences in the length of hospital stay (11.8±5.2 days versus 14.4±6.4 days, p=0.21), operative duration (176±72 minutes versus 213±41 minutes, p=0.10), and estimated blood loss (1,000±1,280 mL versus 1,100±790 mL, p>0.05) between the posterior-only and combined anterior-posterior groups.

4) Postoperative mortality and postoperative complications

Postoperative mortality in four of the five included studies was not reported. Only three included studies recorded information on postoperative complications [5,7,8]. Been and Bouma [5] reported an overall complication rate of 14.8% (four of 27 patients, i.e., one infection, one instrumentation failure, and two misplaced pedicle screws) in the combined anterior-posterior group compared with 26.3% (five of 19 patients, i.e., one infection and four instrumentation failures) in the posterior-only group. There was a 3.7% (one of 27 patients) and 21.1% (four of 19 patients) rate of construct failure (instrumentation breakage without clinical consequence) in the combined anterior-posterior and posterior-only groups, respectively.

Danisa et al. [7] reported an overall complication rate of 50.0% (three of six patients, i.e., one iatrogenic thoracic duct laceration intraoperatively, one apical pneumothorax, and one Kaneda device screw loosening) in the combined anterior-posterior group compared with 14.8% (four of 27 patients, i.e., two infections, one pseudarthrosis, and one deep vein thrombosis) in the posterior-only group. The rate of construct failure in the combined anterior-posterior and posterior-only groups were 16.7% (one of six patients) and 3.7% (one of 27 patients), respectively, without clinical sequelae. Mayer et al. [8] reported no instrumentation failure or breakage in all patients.

5) Relationship among the number of levels instrumented posteriorly, anterior column reconstruction, and construct failure rate

As mentioned, the method of fixation was heterogeneous between and within studies. In the combined anterior-posterior group, the number of levels instrumented during the posterior approach was specified only in Mayer et al. [8] and Schmid et al. [9] (both short segment, i.e., one level above and one level below the fractured vertebrae). The posterior groups in the two studies had short-segment fixation only. Mayer et al. [8] reported no instances of construct failure in both groups. However, this endpoint was not reported by Schmid et al. [9]. The number of segments instrumented posteriorly was not specified in the other three studies [5-7]. No studies specifically investigated the relationship among the number of levels instrumented posteriorly, anterior fixation, and postoperative construct failure. Thus, drawing any useful conclusions in this domain is not possible.

6) Postoperative Cobb angle at follow-up

Four studies had sufficient data on long-term postoperative Cobb angle for meta-analysis [5,7-9] (Fig. 2). The collected postoperative Cobb angles for the combined anterior-posterior and for the posterior approaches were 8.5º (range, 2.4º–18.5º) and 8.5º (range, 4.1º–14.7º), respectively. No significant difference in postoperative Cobb angle at the final follow-up was observed between the combined anterior-posterior and posterior approaches (MD, 2.45; 95% CI, −1.1 to 6.0; p=0.177).

Fig. 2.

Postoperative Cobb angle deformity at follow-up.

To evaluate the durability of the combined anterior-posterior and posterior approaches in correcting kyphotic deformity, available data regarding the change in the Cobb angle from the preoperative to the postoperative state from three studies were gathered and analyzed [7-9]. The change in the Cobb angle in the combined anterior-posterior approach was 7.5º (range, 3.0º–12.0º) compared with 4.2º (range, −3.6º to 10.4º) in the posterior approach. No significant differences were observed on the change in the Cobb angle at the final postoperative follow-up between the combined anterior-posterior and posterior approaches (MD, −4.13; 95% CI, −9.0 to 0.77; p=0.098) (Fig. 3).

Fig. 3.

Change in the Cobb angle at the final follow-up (compared with the preoperative state).

7) Functional patient outcomes

Four studies reported functional patient outcomes using validated measures [6-9]. Utilizing the physical functioning, bodily pain, and mental health scales of the 36-item Short-Form Health Survey (SF-36) questionnaire, Briem et al. [6] reported no significant differences between the combined anterior-posterior and posterior-only groups. Mayer et al. [8] also reported no significant difference (p>0.5) in the physical and mental component summaries of the SF-36 between the two groups. Mayer et al. [8] and Schmid et al. [9] both reported no significant differences on VAS scores specific for back pain between the combined anterior-posterior and posterior-only groups at postoperative follow-up.

Regarding return to work, Danisa et al. [7] reported a 60% rate of return to work for both groups, whereas Schmid et al. [9] reported 78.6% and 95.2% rates of return to at least some form of employment in the combined anterior-posterior and posterior-only groups, respectively, but this difference was not statistically significant (p=0.18).

Table 3 summarizes the findings of the reported functional outcome measures of the relevant included articles.

Table 3.

Summary of patient functional outcomes

Variable			Anterior-posterior group	Posterior group
Briem et al. [6] (2004)
	SF-36 Physical Function Index		77.5±3.89	68.98±9.96
	SF-36 Body Pain Index		60.7±8.68	68.5±7.31
	SF-36 Mental Health Index		76.6±4.13	75.2±6.13
Danisa et al. [7] (1995)
	Denis Pain Index
		P1–P2 (minimal to no pain)	P1–P2: 40	P1–P2: 35
		P3 (moderate pain)	P3: 20	P3: 20
		P4–5 (moderate to severe pain)	P4–5: 40	P4–5: 45
	Denis work
		W1–W2 (return to previous employment [heavy labor] or return to previous sedentary employment/heavy labor with restrictions)	W1–W2: 60	W1–W2: 60
		W3 (unable to return to previous employment but has returned to full-time work)	W3: 0	W3: 0
		W4–W5 (unable to return to full-time work or unable to return to any employment)	W4–5: 40	W4–5: 39
		Return to work (%)	60	60
Mayer et al. [8] (2017)
	Oswestry Disability Index		20±20	16.3±17.1
	SF-36 Physical Component Score		46.1±14.3	49.3±9.4
	SF-36 Mental Component Score		45.7±14.3	51±14.1
	Visual Analogue Scale		32.1±27.8	17.1±18.2
	RMDQ		4.6±6.0	3.3±4.2
Schmid et al. [9] (2012)
	Visual Analogue Scale (postoperative)		68.4±17.4	73±21.3
	RMDQ		4.9±4.0	4.4±4.4
	Return to work (%)		78.6	95.2

Values are presented as mean±standard deviation or %.

SF-36, 36-item Short-Form Health Survey; RMDQ, Roland Morris Disability Questionnaire.

4. Quality assessment of individual studies

By utilizing the Newcastle-Ottawa scale for observational cohort studies, three studies were found to be of good quality [5,8,9], and two studies were of poor quality [6,7] (Table 4). The study by Danisa et al. [7] was downgraded for the lack of comparison of demographic variables between groups at baseline and the study by Briem et al. [6] for the lack of specification of the adequacy and proportion of patients who were successfully followed up postoperatively.

Table 4.

Risk of bias assessment of included observational studies according to the Newcastle-Ottawa Quality Assessment Scale

Author (year)	Selection				Comparability	Outcome
	Representativeness of cohort	Selection of nonexposed cohort	Ascertainment of exposure	Outcome of interest	Comparability of cohorts	Assessment of outcome	Adequate duration of follow-up	Adequate follow-up of cohort
Been and Bouma et al. [5] (1999)	*	*	*	*	**	*	*	*
Briem et al. [6] (2004)	*	*	*	*	**	*	-	-
Danisa et al. [7] (1995)	*	*	*	*	-	*	*	*
Mayer et al. [8] (2017)	*	*	*	*	**	*	*	*
Schmid et al. [9] (2012)	*	*	*	*	**	*	*	-

As judged by the Newcastle-Ottawa Quality Assessment Scale, maximum of one star awarded for each category within selection and outcome. Maximum of two stars awarded for comparability."

Discussion

The management of traumatic thoracolumbar burst fractures remains controversial. Evidence-based management of these fractures has been inhibited by the lack of separation/classification of the different fracture types included in a single study. In an attempt to reduce this heterogeneity, the present systematic review has included burst-only fractures without distraction or translational injuries.

Relative indications for the surgical management of traumatic thoracolumbar burst fractures are (1) reversal/stabilization of neurological deficit, (2) more than 50% spinal canal compromise, and (3) deformity correction (e.g., kyphotic Cobb angle above 25º). Other potential surgical management markers include intractable back pain in a morphologically stable fracture and concomitant traumatic injuries (e.g., multiple rib fractures). The surgeon has to determine the best approach (i.e., anterior-only, posterior-only, or combined anterior-posterior), each with their relative advantages and disadvantages. A comparison between isolated anterior and posterior approaches has been the focus of previous systematic reviews and are outside the scope of this study [10,11]. These reviews have largely found no differences in terms of the neurological, functional, and quality-of-life outcomes between the anterior-only and the posterior-only approaches.

A combined anterior-posterior approach results in a patient receiving a longer total operative time, higher estimated blood loss, and longer hospital stay than a posterior-only approach. These findings are consistent with those reported by Danisa et al. [7] and Schmid et al. [9]. However, the combined anterior-posterior approach has the presumed advantages of allowing (1) a short-segment posterior fixation, which may be desirable in limiting disruption to lower lumbar motion segments [12]; (2) better kyphotic deformity correction [13]; and (3) direct fracture fragment removal for canal decompression.

Regarding short-versus long-segment fixation in thoracolumbar burst fractures, not enough data were available in this systematic review to conclude on the effect of anterior fixation and fusion on the number of levels required to be fixated posteriorly. The number of levels fixated posteriorly and the method of posterior instrumented fusion were heterogeneous between the studies in this review (Table 2). However, when considering short- versus long-segment posterior fixation (without anterior fixation) in thoracolumbar burst fractures, a recent meta-analysis by Aly [14] found no difference in the clinical, radiological (including kyphotic deformity), and functional outcomes. In this review, no evidence of a superior neurological outcome or less kyphotic deformity was found when comparing the combined anterior-posterior approach to the posterior-only approach. Furthermore, no statistically significant difference in terms of the change in the Cobb angle was observed at the final follow-up, indicating equivalence in the degree of deformity correction between the approaches. Nevertheless, anterior fixation in a combined anterior-posterior approach is likely to retain importance in selected cases with severe anterior column disruption [12].

With the development of minimally invasive surgery, the modern anterior approach applied to the thoracolumbar spine is considerably improved compared with the traditional open approach. In a retrospective cohort study comparing mini-open and traditional open anterior approaches to the thoracolumbar spine, Sulaiman et al. [15] reported a significantly reduced operative time, estimated blood loss, length of stay, and direct hospital costs in the mini-open group. The anterior approach may be a less major undertaking using contemporary techniques. Similarly, minimally invasive posterior techniques have been developed for thoracolumbar fractures. Compared with open approaches, percutaneous pedicle screw fixation has been found to result in reduced blood loss, shorter surgery, and similar VAS scores [16]. In recent meta-analyses, this approach had a shorter length of hospital stay, lower surgical site infection rate, and no differences in the postoperative Cobb angle [17,18].

The main limitations of this systematic review lie in the characteristics and quality of the included articles. While limiting included articles to burst fractures only was helpful in reducing between-study heterogeneity, the inclusion of only isolated burst fractures reduced the number of articles meeting inclusion criteria. Included articles comprised patients who are neurologically intact and nonintact, and the subgroup analysis of the two groups were not performed. In practice, the clinical gestalt toward thoracolumbar burst fractures with neurological deficit is significantly different to that of a neurologically intact patient, as formalized in the Thoracolumbar Injury Classification System. Various specific techniques are used in each of the anterior and posterior approaches (Table 2), which accounts for at least some of the interstudy differences in the clinical outcomes of interest. Due to the small number of studies reporting each outcome of interest (see “Results” section), all except one outcome variable (i.e., postoperative Cobb angle) were unsuitable for meta-analysis. The authors decided not to apply meta-analyses to the outcome variables that were reported by two or less studies.

The ideal conceptual framework and study design to investigate different surgical approaches in thoracolumbar fractures is a well-designed randomized controlled trial (RCT). However, such an RCT is practically difficult to conduct, especially with respect to the study power and standardizing precise surgical procedures performed. An alternative to RCT is the utilization of large, prospective registries together with machine learning to investigate outcome differences between approaches. The application of artificial intelligence in spine surgery is a burgeoning field [19] and has the potential to predict preoperative variables that may benefit from a particular approach.

Conclusions

The current best available evidence does not present any difference in clinical, radiologic (including kyphotic deformity), and functional patient outcomes between the combined anterior-posterior approach and the posterioronly approach in the management of traumatic thoracolumbar burst fractures. The combined anterior-posterior approach shows longer operative duration, increased blood loss, and longer length of hospital stay. Further studies are required to determine if a specific subset of patients with thoracolumbar burst fractures will benefit from a combined anterior-posterior approach.