PURPOSE: We describe the cardiovascular risk profile in a representative cohort of patients with prostate cancer treated with or without androgen deprivation therapy. MATERIALS AND METHODS: We prospectively characterized in detail 2,492 consecutive men (mean age 68 years) with prostate cancer (newly diagnosed or with a plan to prescribe androgen deprivation therapy for the first time) from 16 Canadian sites. Cardiovascular risk was estimated by calculating Framingham risk scores. RESULTS: Most men (92%) had new prostate cancer (intermediate risk 41%, high risk 50%). The highest level of education achieved was primary school in 12%. Most (58%) were current or former smokers, 22% had known cardiovascular disease, 16% diabetes, 45% hypertension, 31% body mass index 30 kg/m2 or greater, 24% low levels of physical activity, mean handgrip strength was 37.3 kg and 69% had a Framingham risk score consistent with high cardiovascular risk. Participants in whom androgen deprivation therapy was planned had higher Framingham risk scores than those not intending to receive androgen deprivation therapy, and this risk was abolished after adjustment for confounders. CONCLUSIONS: Two-thirds of men with prostate cancer are at high cardiovascular risk. There is a positive association between a plan to use androgen deprivation therapy and baseline cardiovascular risk factors. However, this association is explained by confounding factors.
PURPOSE: We describe the cardiovascular risk profile in a representative cohort of patients with prostate cancer treated with or without androgen deprivation therapy. MATERIALS AND METHODS: We prospectively characterized in detail 2,492 consecutive men (mean age 68 years) with prostate cancer (newly diagnosed or with a plan to prescribe androgen deprivation therapy for the first time) from 16 Canadian sites. Cardiovascular risk was estimated by calculating Framingham risk scores. RESULTS: Most men (92%) had new prostate cancer (intermediate risk 41%, high risk 50%). The highest level of education achieved was primary school in 12%. Most (58%) were current or former smokers, 22% had known cardiovascular disease, 16% diabetes, 45% hypertension, 31% body mass index 30 kg/m2 or greater, 24% low levels of physical activity, mean handgrip strength was 37.3 kg and 69% had a Framingham risk score consistent with high cardiovascular risk. Participants in whom androgen deprivation therapy was planned had higher Framingham risk scores than those not intending to receive androgen deprivation therapy, and this risk was abolished after adjustment for confounders. CONCLUSIONS: Two-thirds of men with prostate cancer are at high cardiovascular risk. There is a positive association between a plan to use androgen deprivation therapy and baseline cardiovascular risk factors. However, this association is explained by confounding factors.
Authors: Renato D Lopes; Celestia S Higano; Susan F Slovin; Adam J Nelson; Robert Bigelow; Per S Sørensen; Chiara Melloni; Shaun G Goodman; Christopher P Evans; Jan Nilsson; Deepak L Bhatt; Noel W Clarke; Tine K Olesen; Belinda T Doyle-Olsen; Henriette Kristensen; Lauren Arney; Matthew T Roe; John H Alexander Journal: Circulation Date: 2021-08-30 Impact factor: 39.918
Authors: Jen-Tsan Chi; Pao-Hwa Lin; Vladimir Tolstikov; Taofik Oyekunle; Gloria C G Alvarado; Adela Ramirez-Torres; Emily Y Chen; Valerie Bussberg; Bo Chi; Bennett Greenwood; Rangaprasad Sarangarajan; Niven R Narain; Michael A Kiebish; Stephen J Freedland Journal: Prostate Date: 2021-05-05 Impact factor: 4.012
Authors: Lova Sun; Ravi B Parikh; Rebecca A Hubbard; John Cashy; Samuel U Takvorian; David J Vaughn; Kyle W Robinson; Vivek Narayan; Bonnie Ky Journal: JAMA Netw Open Date: 2021-02-01
Authors: Azariyas A Challa; Adam Christopher Calaway; Jennifer Cullen; Jorge Garcia; Nihar Desai; Neal L Weintraub; Anita Deswal; Shelby Kutty; Ajay Vallakati; Daniel Addison; Ragavendra Baliga; Courtney M Campbell; Avirup Guha Journal: Curr Treat Options Oncol Date: 2021-04-17