Literature DB >> 31897927

Integration of hepatitis B virus DNA into p21-activated kinase 3 (PAK3) gene in HepG2.2.15 cells.

Peng Ruan1,2,3, Xiufang Dai4, Jun Sun5, Chunping He5, Chao Huang5, Rui Zhou5, Isabelle Chemin6.   

Abstract

Integration of HBV DNA into host chromosomes was found in most of the patients with chronic hepatitis B (CHB). In this study, using inverse nested PCR (invPCR), we found the integration site chrX: 111,009,033, which inserted into the p21-activated kinase 3 (PAK3) gene in HepG2.2.15 cells. The viral-human chimeric transcripts were also observed and, significant differences of the copy numbers of integration site chrX: 111,009,033 (P = 0.012) and intra-cell HBV DNA levels (P = 0.027) were found between the cells with and without H2O2 treatment, respectively. This study may provide a novel insight into the elucidation of etiology of HBV integration.

Entities:  

Keywords:  Chronic hepatitis B; HBV integration; Hepatitis B virus; Inverse nested PCR; p21-activated kinase 3 gene

Mesh：

Substances：

Year:  2020        PMID： 31897927     DOI： 10.1007/s11262-019-01725-4

Source DB:  PubMed          Journal:  Virus Genes        ISSN： 0920-8569            Impact factor:   2.332


  33 in total

1.  Alteration of gene expression in human hepatocellular carcinoma with integrated hepatitis B virus DNA.

Authors:  Akihiro Tamori; Yoshihiro Yamanishi; Shuichi Kawashima; Minoru Kanehisa; Masaru Enomoto; Hiromu Tanaka; Shoji Kubo; Susumu Shiomi; Shuhei Nishiguchi
Journal:  Clin Cancer Res       Date:  2005-08-15       Impact factor: 12.531

2.  The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients.

Authors:  Zhaoshi Jiang; Suchit Jhunjhunwala; Jinfeng Liu; Peter M Haverty; Michael I Kennemer; Yinghui Guan; William Lee; Paolo Carnevali; Jeremy Stinson; Stephanie Johnson; Jingyu Diao; Stacy Yeung; Adrian Jubb; Weilan Ye; Thomas D Wu; Sharookh B Kapadia; Frederic J de Sauvage; Robert C Gentleman; Howard M Stern; Somasekar Seshagiri; Krishna P Pant; Zora Modrusan; Dennis G Ballinger; Zemin Zhang
Journal:  Genome Res       Date:  2012-01-20       Impact factor: 9.043

3.  Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism.

Authors:  Zheng Hu; Da Zhu; Wei Wang; Weiyang Li; Wenlong Jia; Xi Zeng; Wencheng Ding; Lan Yu; Xiaoli Wang; Liming Wang; Hui Shen; Changlin Zhang; Hongjie Liu; Xiao Liu; Yi Zhao; Xiaodong Fang; Shuaicheng Li; Wei Chen; Tang Tang; Aisi Fu; Zou Wang; Gang Chen; Qinglei Gao; Shuang Li; Ling Xi; Changyu Wang; Shujie Liao; Xiangyi Ma; Peng Wu; Kezhen Li; Shixuan Wang; Jianfeng Zhou; Jun Wang; Xun Xu; Hui Wang; Ding Ma
Journal:  Nat Genet       Date:  2015-01-12       Impact factor: 38.330

4.  Characterization of the genotype and integration patterns of hepatitis B virus in early- and late-onset hepatocellular carcinoma.

Authors:  Hongli Yan; Yuan Yang; Ling Zhang; Guannan Tang; YuZhao Wang; Geng Xue; Weiping Zhou; Shuhan Sun
Journal:  Hepatology       Date:  2015-03-18       Impact factor: 17.425

5.  Viral-human chimeric transcript predisposes risk to liver cancer development and progression.

Authors:  Chi-Chiu Lau; Tingting Sun; Arthur K K Ching; Mian He; Jing-Woei Li; Alissa M Wong; Ngai Na Co; Anthony W H Chan; Pik-Shan Li; Raymond W M Lung; Joanna H M Tong; Paul B S Lai; Henry L Y Chan; Ka-Fai To; Ting-Fung Chan; Nathalie Wong
Journal:  Cancer Cell       Date:  2014-02-27       Impact factor: 31.743

6.  HIVID: an efficient method to detect HBV integration using low coverage sequencing.

Authors:  Weiyang Li; Xi Zeng; Nikki P Lee; Xiao Liu; Shengpei Chen; Bing Guo; Shang Yi; Xuehan Zhuang; Fang Chen; Guan Wang; Ronnie T Poon; Sheung Tat Fan; Mao Mao; Yingrui Li; Songgang Li; Jun Wang; Xun Xu; Hui Jiang; Xiuqing Zhang
Journal:  Genomics       Date:  2013-07-15       Impact factor: 5.736

7.  Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide.

Authors:  I U Schraufstatter; D B Hinshaw; P A Hyslop; R G Spragg; C G Cochrane
Journal:  J Clin Invest       Date:  1986-04       Impact factor: 14.808

8.  Integration of hepatitis B virus DNA into the myeloid/lymphoid or mixed-lineage leukemia (MLL4) gene and rearrangements of MLL4 in human hepatocellular carcinoma.

Authors:  Kenichi Saigo; Kenichi Yoshida; Ryuji Ikeda; Yoshiko Sakamoto; Yoshiki Murakami; Tetsuro Urashima; Takehide Asano; Takashi Kenmochi; Ituro Inoue
Journal:  Hum Mutat       Date:  2008-05       Impact factor: 4.878

9.  Different types of viral‑host junction found in HBV integration breakpoints in HBV‑infected patients.

Authors:  Peng Ruan; Xiufang Dai; Jun Sun; Chunping He; Chao Huang; Rui Zhou; Zhuo Cao; Lan Ye
Journal:  Mol Med Rep       Date:  2018-11-29       Impact factor: 2.952

10.  Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma.

Authors:  Liu Yang; Song Ye; Xinyi Zhao; Liyan Ji; Yinxin Zhang; Pingyu Zhou; Jun Sun; Yanfang Guan; Yingxin Han; Chao Ni; Xiaoge Hu; Weilong Liu; Haiyan Wang; Boping Zhou; Jian Huang
Journal:  J Cancer       Date:  2018-09-07       Impact factor: 4.207
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  1 in total

1.  Targeted Long-Read Sequencing Reveals Comprehensive Architecture, Burden, and Transcriptional Signatures from Hepatitis B Virus-Associated Integrations and Translocations in Hepatocellular Carcinoma Cell Lines.

Authors:  Ricardo Ramirez; Nicholas van Buuren; Lindsay Gamelin; Cameron Soulette; Lindsey May; Dong Han; Mei Yu; Regina Choy; Guofeng Cheng; Neeru Bhardwaj; Joy Chiu; Robert C Muench; William E Delaney; Hongmei Mo; Becket Feierbach; Li Li
Journal:  J Virol       Date:  2021-07-21       Impact factor: 5.103
  1 in total

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