Oi-Wa Chan1, Jainn-Jim Lin2,3,4, Shao-Hsuan Hsia1, Chia-Ying Lin1, Kung-Lin Lin5. 1. Division of Pediatric Critical Care Medicine and Pediatric Neurocritical Care Center, Chang Gung Children's Hospital and Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan. 2. Division of Pediatric Critical Care Medicine and Pediatric Neurocritical Care Center, Chang Gung Children's Hospital and Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan. lin0227@adm.cgmh.org.tw. 3. Division of Pediatric Neurology, Chang Gung Children's Hospital and Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan. lin0227@adm.cgmh.org.tw. 4. Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan. lin0227@adm.cgmh.org.tw. 5. Division of Pediatric Neurology, Chang Gung Children's Hospital and Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Abstract
PURPOSE: The role of methylprednisolone pulse therapy as adjuvant treatment of Streptococcus pneumoniae meningitis complicated by cerebral infarction has rarely been reported. METHODS: We reported a case report and also performed a systematic literature review. RESULTS: A 1-year 2-month-old boy who presented with high fever, status epilepticus, and septic shock was diagnosed with cerebral infarction caused by Streptococcus pneumoniae meningitis on magnetic resonance imaging (MRI). He was treated with methylprednisolone pulse therapy and his clinical condition gradually improved thereafter. At the follow-up visit 1 year after discharge, he was able to sit without support, but he had moderate delays in speech and developmental milestones and epilepsy sequelae. CONCLUSION: In severe cases, the use of high-dose methylprednisolone should be considered to modulate the inflammatory response in patients with severe cerebral infarction caused by Streptococcus pneumoniae meningitis.
PURPOSE: The role of methylprednisolone pulse therapy as adjuvant treatment of Streptococcus pneumoniae meningitis complicated by cerebral infarction has rarely been reported. METHODS: We reported a case report and also performed a systematic literature review. RESULTS: A 1-year 2-month-old boy who presented with high fever, status epilepticus, and septic shock was diagnosed with cerebral infarction caused by Streptococcus pneumoniae meningitis on magnetic resonance imaging (MRI). He was treated with methylprednisolone pulse therapy and his clinical condition gradually improved thereafter. At the follow-up visit 1 year after discharge, he was able to sit without support, but he had moderate delays in speech and developmental milestones and epilepsy sequelae. CONCLUSION: In severe cases, the use of high-dose methylprednisolone should be considered to modulate the inflammatory response in patients with severe cerebral infarction caused by Streptococcus pneumoniae meningitis.
Authors: S Ilia; A-M Spanaki; M Raissaki; V I Spoulou; M-D Fitrolaki; M Kanariou; G Tzanakaki; G Briassoulis Journal: Neuropediatrics Date: 2011-11-14 Impact factor: 1.947
Authors: Philippe G Jorens; Paul M Parizel; Hendrik E Demey; Katrien Smets; Kris Jadoul; M M Verbeek; R A Wevers; Patrick Cras Journal: Neuroradiology Date: 2005-09-07 Impact factor: 2.804
Authors: R I Aviv; S M Benseler; G DeVeber; E D Silverman; P N Tyrrell; L M Tsang; D Armstrong Journal: AJNR Am J Neuroradiol Date: 2007-01 Impact factor: 3.825
Authors: Marc Auburtin; Raphaël Porcher; Fabrice Bruneel; Agnès Scanvic; Jean Louis Trouillet; Jean Pierre Bédos; Bernard Régnier; Michel Wolff Journal: Am J Respir Crit Care Med Date: 2002-03-01 Impact factor: 21.405