Literature DB >> 31897452

Clinical Judgement Study using Question Answering from Electronic Health Records.

Bhanu Pratap Singh Rawat1, Fei Li2, Hong Yu2.   

Abstract

Clinical judgement studies are essential for recognising the causal relation of a medication with adverse drug reactions (ADRs). Traditionally, these studies are conducted via expert manual chart review. By contrast, we propose an end-to-end deep learning question answering model to automatically infer such causal relations. Our proposed model identifies the causal relation by answering a subset of Naranjo questionnaire Naranjo et al. (1981) from electronic health records. It employs multi-level attention layers along with local and global context while answering these questions. Our proposed model achieves a macroweighted F-score of 0.4598 - 0.5142 across the selected questions and an overall F-score of 0.5011. We also did an ablation study to validate the importance of local and global context for the model.

Entities:  

Year:  2019        PMID: 31897452      PMCID: PMC6939641     

Source DB:  PubMed          Journal:  Proc Mach Learn Res


  16 in total

1.  Extraction of adverse drug effects from clinical records.

Authors:  Eiji Aramaki; Yasuhide Miura; Masatsugu Tonoike; Tomoko Ohkuma; Hiroshi Masuichi; Kayo Waki; Kazuhiko Ohe
Journal:  Stud Health Technol Inform       Date:  2010

2.  Framewise phoneme classification with bidirectional LSTM and other neural network architectures.

Authors:  Alex Graves; Jürgen Schmidhuber
Journal:  Neural Netw       Date:  2005 Jun-Jul

3.  A prospective study on Adverse Drug Reactions of antibiotics in a tertiary care hospital.

Authors:  M Shamna; C Dilip; M Ajmal; P Linu Mohan; C Shinu; C P Jafer; Yahiya Mohammed
Journal:  Saudi Pharm J       Date:  2014-09       Impact factor: 4.330

4.  Adverse drug reactions in hospital in-patients: a pilot study.

Authors:  E C Davies; C F Green; D R Mottram; M Pirmohamed
Journal:  J Clin Pharm Ther       Date:  2006-08       Impact factor: 2.512

5.  A method for estimating the probability of adverse drug reactions.

Authors:  C A Naranjo; U Busto; E M Sellers; P Sandor; I Ruiz; E A Roberts; E Janecek; C Domecq; D J Greenblatt
Journal:  Clin Pharmacol Ther       Date:  1981-08       Impact factor: 6.875

6.  Adverse drug events in hospitalized patients. Excess length of stay, extra costs, and attributable mortality.

Authors:  D C Classen; S L Pestotnik; R S Evans; J F Lloyd; J P Burke
Journal:  JAMA       Date:  1997 Jan 22-29       Impact factor: 56.272

7.  Adverse drug reaction monitoring in a secondary care hospital in South India.

Authors:  R Arulmani; S D Rajendran; B Suresh
Journal:  Br J Clin Pharmacol       Date:  2007-07-27       Impact factor: 4.335

8.  A study of adverse drug reactions in pediatric patients.

Authors:  R Priyadharsini; A Surendiran; C Adithan; S Sreenivasan; Firoj Kumar Sahoo
Journal:  J Pharmacol Pharmacother       Date:  2011-10

9.  A study of cutaneous adverse drug reactions at a tertiary center in Jammu, India.

Authors:  Rohini Sharma; Devraj Dogra; Naina Dogra
Journal:  Indian Dermatol Online J       Date:  2015 May-Jun

10.  Adverse drug reactions in hospital in-patients: a prospective analysis of 3695 patient-episodes.

Authors:  Emma C Davies; Christopher F Green; Stephen Taylor; Paula R Williamson; David R Mottram; Munir Pirmohamed
Journal:  PLoS One       Date:  2009-02-11       Impact factor: 3.240

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