Literature DB >> 31894779

Elastase-triggered H2S delivery from polymer hydrogels.

Mingjun Zhou1, Yun Qian, Yumeng Zhu, John Matson.   

Abstract

We report an elastase-responsive, H2S-releasing hydrogel prepared by covalently crosslinking a mixture of carboxymethylcellulose and poly(ethylene glycol) with an elastase-degradable peptide functionalized with an H2S-releasing S-aroylthiooxime (SATO) unit. Addition of elastase triggered a gel-to-sol transition, which exposed SATOs, leading to more and longer H2S release compared to untriggered gels.

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Year:  2020        PMID： 31894779      PMCID： PMC7001589          DOI： 10.1039/c9cc08752d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  32 in total

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Review 3.  The Benefits of Macromolecular/Supramolecular Approaches in Hydrogen Sulfide Delivery: A Review of Polymeric and Self-Assembled Hydrogen Sulfide Donors.

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Review 5.  Regulation and role of endogenously produced hydrogen sulfide in angiogenesis.

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6.  A Persulfide Donor Responsive to Reactive Oxygen Species: Insights into Reactivity and Therapeutic Potential.

Authors:  Chadwick R Powell; Kearsley M Dillon; Yin Wang; Ryan J Carrazzone; John B Matson
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Review 7.  The Cardioprotective Effects of Hydrogen Sulfide in Heart Diseases: From Molecular Mechanisms to Therapeutic Potential.

Authors:  Yaqi Shen; Zhuqing Shen; Shanshan Luo; Wei Guo; Yi Zhun Zhu
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8.  TNF/TNF-R1 pathway is involved in doxorubicin-induced acute sterile inflammation.

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Journal:  Cell Death Dis       Date:  2013-12-12       Impact factor: 8.469

9.  Hydrogen sulfide ameliorates chronic renal failure in rats by inhibiting apoptosis and inflammation through ROS/MAPK and NF-κB signaling pathways.

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Journal:  Sci Rep       Date:  2017-03-28       Impact factor: 4.379

10.  The protective effect of hydrogen sulfide on systemic sclerosis associated skin and lung fibrosis in mice model.

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Journal:  Springerplus       Date:  2016-07-15
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  3 in total

Review 1.  The evolving landscape for cellular nitric oxide and hydrogen sulfide delivery systems: A new era of customized medications.

Authors:  Kearsley M Dillon; Ryan J Carrazzone; John B Matson; Khosrow Kashfi
Journal:  Biochem Pharmacol       Date:  2020-03-26       Impact factor: 5.858

2.  H2S-releasing amphiphilic dipeptide hydrogels are potent S. aureus biofilm disruptors.

Authors:  Yun Qian; Afnan Altamimi; Shaina Alston Yates; Santu Sarkar; Matthew Cochran; Mingjun Zhou; Nicole Levi-Polyachenko; John B Matson
Journal:  Biomater Sci       Date:  2020-03-31       Impact factor: 6.843

Review 3.  Intelligent polymeric hydrogen sulfide delivery systems for therapeutic applications.

Authors:  Fan Rong; Tengjiao Wang; Qian Zhou; Haowei Peng; Jingtian Yang; Quli Fan; Peng Li
Journal:  Bioact Mater       Date:  2022-04-13
  3 in total

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