Shannon M Sheppard1, Lynsey M Keator2, Bonnie L Breining2, Amy E Wright2, Sadhvi Saxena2, Donna C Tippett2, Argye E Hillis2. 1. From the Departments of Neurology (S.M.S., L.M.K., B.L.B., A.E.W., S.S., D.C.T., A.E.H.), Physical Medicine and Rehabilitation (D.C.T., A.E.H.), and Otolaryngology-Head and Neck Surgery (D.C.T.), Johns Hopkins University School of Medicine; and Department of Cognitive Science (A.E.H.), Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD. sheppard@jhmi.edu. 2. From the Departments of Neurology (S.M.S., L.M.K., B.L.B., A.E.W., S.S., D.C.T., A.E.H.), Physical Medicine and Rehabilitation (D.C.T., A.E.H.), and Otolaryngology-Head and Neck Surgery (D.C.T.), Johns Hopkins University School of Medicine; and Department of Cognitive Science (A.E.H.), Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD.
Abstract
OBJECTIVE: To determine whether right ventral stream and limbic structures (including posterior superior temporal gyrus [STG], STG, temporal pole, inferior frontal gyrus pars orbitalis, orbitofrontal cortex, amygdala, anterior cingulate, gyrus, and the sagittal stratum) are implicated in emotional prosody identification. METHODS: Patients with MRI scans within 48 hours of unilateral right hemisphere ischemic stroke were enrolled. Participants were presented with 24 sentences with neutral semantic content spoken with happy, sad, angry, afraid, surprised, or bored prosody and chose which emotion the speaker was feeling based on tone of voice. Multivariable linear regression was used to identify individual predictors of emotional prosody identification accuracy from a model, including percent damage to proposed right hemisphere structures, age, education, and lesion volume across all emotions (overall emotion identification) and 6 individual emotions. Patterns of recovery were also examined at the chronic stage. RESULTS: The overall emotion identification model was significant (adjusted r 2 = 0.52; p = 0.043); greater damage to right posterior STG (p = 0.038) and older age (p = 0.009) were individual predictors of impairment. The model for recognition of fear was also significant (adjusted r 2 = 0.77; p = 0.002), with greater damage to right amygdala (p = 0.047), older age (p < 0.001), and less education (p = 0.005) as individual predictors. Over half of patients with chronic stroke had residual impairments. CONCLUSIONS: Right posterior STG in the right hemisphere ventral stream is critical for emotion identification in speech. Patients with stroke with damage to this area should be assessed for emotion identification impairment.
OBJECTIVE: To determine whether right ventral stream and limbic structures (including posterior superior temporal gyrus [STG], STG, temporal pole, inferior frontal gyrus pars orbitalis, orbitofrontal cortex, amygdala, anterior cingulate, gyrus, and the sagittal stratum) are implicated in emotional prosody identification. METHODS: Patients with MRI scans within 48 hours of unilateral right hemisphere ischemic stroke were enrolled. Participants were presented with 24 sentences with neutral semantic content spoken with happy, sad, angry, afraid, surprised, or bored prosody and chose which emotion the speaker was feeling based on tone of voice. Multivariable linear regression was used to identify individual predictors of emotional prosody identification accuracy from a model, including percent damage to proposed right hemisphere structures, age, education, and lesion volume across all emotions (overall emotion identification) and 6 individual emotions. Patterns of recovery were also examined at the chronic stage. RESULTS: The overall emotion identification model was significant (adjusted r 2 = 0.52; p = 0.043); greater damage to right posterior STG (p = 0.038) and older age (p = 0.009) were individual predictors of impairment. The model for recognition of fear was also significant (adjusted r 2 = 0.77; p = 0.002), with greater damage to right amygdala (p = 0.047), older age (p < 0.001), and less education (p = 0.005) as individual predictors. Over half of patients with chronic stroke had residual impairments. CONCLUSIONS: Right posterior STG in the right hemisphere ventral stream is critical for emotion identification in speech. Patients with stroke with damage to this area should be assessed for emotion identification impairment.
Authors: David I Leitman; Daniel H Wolf; J Daniel Ragland; Petri Laukka; James Loughead; Jeffrey N Valdez; Daniel C Javitt; Bruce I Turetsky; Ruben C Gur Journal: Front Hum Neurosci Date: 2010-02-26 Impact factor: 3.169
Authors: Shannon M Sheppard; Melissa D Stockbridge; Lynsey M Keator; Laura L Murray; Margaret Lehman Blake Journal: J Int Neuropsychol Soc Date: 2022-01-06 Impact factor: 3.114
Authors: Jamila Minga; Davida Fromm; Adam Jacks; Melissa D Stockbridge; Jennifer Nelthropp; Brian MacWhinney Journal: J Speech Lang Hear Res Date: 2022-01-25 Impact factor: 2.674
Authors: Shannon M Sheppard; Erin L Meier; Alexandra Zezinka Durfee; Alex Walker; Jennifer Shea; Argye E Hillis Journal: Cortex Date: 2021-04-24 Impact factor: 4.644
Authors: Alexandra Zezinka Durfee; Shannon M Sheppard; Erin L Meier; Lisa Bunker; Erjia Cui; Ciprian Crainiceanu; Argye E Hillis Journal: Brain Sci Date: 2021-05-20