Stephen F Smagula1, Sarah T Stahl2, Tales Santini3, Layla Banihashemi2, Martica H Hall2, Tamer S Ibrahim4, Charles F Reynolds2, Robert T Krafty5, Howard J Aizenstein6, Liang Zhan7. 1. Department of Psychiatry, School of Medicine, University of Pittsburgh (SFS, STS, LB, MHH, TSI, CFR, HJA), Pittsburgh, PA; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh (SFS), Pittsburgh, PA. Electronic address: sfs26@pitt.edu. 2. Department of Psychiatry, School of Medicine, University of Pittsburgh (SFS, STS, LB, MHH, TSI, CFR, HJA), Pittsburgh, PA. 3. Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh (TS, TSI, HJA), Pittsburgh, PA. 4. Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh (TS, TSI, HJA), Pittsburgh, PA; Department of Psychiatry, School of Medicine, University of Pittsburgh (SFS, STS, LB, MHH, TSI, CFR, HJA), Pittsburgh, PA. 5. Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh (RTK), Pittsburgh, PA. 6. Department of Psychiatry, School of Medicine, University of Pittsburgh (SFS, STS, LB, MHH, TSI, CFR, HJA), Pittsburgh, PA; Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh (TS, TSI, HJA), Pittsburgh, PA. 7. Department of Electrical and Computer Engineering, Swanson School of Engineering, University of Pittsburgh (LZ), Pittsburgh, PA.
Abstract
OBJECTIVE: We sought to determine whether the aspects of white matter connectivity implicated in major depression also relate to mild depressive symptoms in family dementia caregivers (dCGs). METHODS: Forty-one dCGs (average age=69 years, standard deviation=6.4) underwent a 7 Tesla 64-direction (12-minute) diffusion-weighted imaging sequence. We compared the fractional anisotropy (FA) of 11 white matter features between dCGs with (n=20) and without (n=21) depressive symptoms (Patient Health Questionnaire-9 scores ≥5). RESULTS: Caregivers reporting depression symptoms had lower FA in tracts connecting to the posterior cingulate cortex (Cohen's d = -0.9) and connecting dorsolateral prefrontal with rostral cingulate regions (Cohen's d = -1.2). CONCLUSIONS: Posterior cingulate and dorsolateral prefrontal-to-rostral cingulate white matter, implicated in prior studies of major depression, appear relevant to mild depression in dCGs.
OBJECTIVE: We sought to determine whether the aspects of white matter connectivity implicated in major depression also relate to mild depressive symptoms in family dementia caregivers (dCGs). METHODS: Forty-one dCGs (average age=69 years, standard deviation=6.4) underwent a 7 Tesla 64-direction (12-minute) diffusion-weighted imaging sequence. We compared the fractional anisotropy (FA) of 11 white matter features between dCGs with (n=20) and without (n=21) depressive symptoms (Patient Health Questionnaire-9 scores ≥5). RESULTS: Caregivers reporting depression symptoms had lower FA in tracts connecting to the posterior cingulate cortex (Cohen's d = -0.9) and connecting dorsolateral prefrontal with rostral cingulate regions (Cohen's d = -1.2). CONCLUSIONS: Posterior cingulate and dorsolateral prefrontal-to-rostral cingulate white matter, implicated in prior studies of major depression, appear relevant to mild depression in dCGs.
Authors: Stephen F Smagula; Scott Beach; Andrea L Rosso; Anne B Newman; Richard Schulz Journal: Am J Geriatr Psychiatry Date: 2017-02-21 Impact factor: 4.105
Authors: Carmen Andreescu; Olusola Ajilore; Howard J Aizenstein; Kimberly Albert; Meryl A Butters; Bennett A Landman; Helmet T Karim; Robert Krafty; Warren D Taylor Journal: Am J Geriatr Psychiatry Date: 2019-08-07 Impact factor: 4.105
Authors: Claire E Sexton; Charlotte L Allan; Marisa Le Masurier; Lisa M McDermott; Ukwuori G Kalu; Lucie L Herrmann; Matthias Mäurer; Kevin M Bradley; Clare E Mackay; Klaus P Ebmeier Journal: Arch Gen Psychiatry Date: 2012-07
Authors: Stephen F Smagula; Brant P Hasler; Richard Schulz; Jessica L Graves; Charles F Reynolds; Howard J Aizenstein; Daniel J Buysse; Robert T Krafty; Martica H Hall Journal: Int Psychogeriatr Date: 2019-10-29 Impact factor: 3.878